{"id":"early-cessation-of-steroids","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This represents a clinical practice or protocol modification rather than a novel drug entity. Early steroid discontinuation aims to minimize cumulative steroid exposure, thereby reducing risks of infection, metabolic complications, and other steroid-related toxicities while maintaining therapeutic efficacy. The approach is typically studied in conditions where steroids are used as adjunctive or short-term therapy.","oneSentence":"Early cessation of steroids reduces prolonged immunosuppression and associated adverse effects by discontinuing corticosteroid therapy at an earlier timepoint than standard practice.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:45:10.725Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Clinical protocol for reducing steroid-related adverse effects in steroid-responsive conditions"}]},"trialDetails":[{"nctId":"NCT07093827","phase":"","title":"A Prospective Cohort Study on the Effect of Spinal Spinal Cord Injury on Sexual Function in Male Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2020-01-01","conditions":"Sexual Function Abnormal, Spinal Cord Injuries (SCI)","enrollment":1600},{"nctId":"NCT05818826","phase":"PHASE2","title":"Early Versus Conventional Cessation of Hydrocortisone in Septic Shock","status":"RECRUITING","sponsor":"Mahidol University","startDate":"2023-07-05","conditions":"Septic Shock, Adverse Event, Hydrocortisone","enrollment":160},{"nctId":"NCT01729494","phase":"PHASE4","title":"Belatacept Early Steroid Withdrawal Trial","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2012-09","conditions":"Renal Transplantation","enrollment":316},{"nctId":"NCT00650468","phase":"PHASE4","title":"A Study to Compare Early Steroid Withdrawal and Long-Term Steroid Maintenance Therapy in Kidney Transplant Patients","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"1999-11","conditions":"Renal Transplantation","enrollment":397}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["prednisone, various"],"phase":"marketed","status":"active","brandName":"early cessation of steroids","genericName":"early cessation of steroids","companyName":"University of Cincinnati","companyId":"university-of-cincinnati","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Early cessation of steroids reduces prolonged immunosuppression and associated adverse effects by discontinuing corticosteroid therapy at an earlier timepoint than standard practice. Used for Clinical protocol for reducing steroid-related adverse effects in steroid-responsive conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}