{"id":"e2nomac","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"E2Nomac acts as a selective estrogen receptor modulator, binding to estrogen receptors with tissue-selective activity. This allows it to provide estrogen agonist effects in some tissues while acting as an antagonist in others, making it suitable for reproductive health indications where selective estrogen modulation is therapeutically beneficial.","oneSentence":"E2Nomac is a selective estrogen receptor modulator (SERM) that modulates estrogen signaling for reproductive health applications.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:35:49.479Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reproductive health applications (specific indication not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT01715025","phase":"PHASE4","title":"A New Treatment Option for Heavy Menstrual Bleeding","status":"UNKNOWN","sponsor":"Sydney Centre for Reproductive Health Research","startDate":"2013-04","conditions":"Menorrhagia","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zoely"],"phase":"marketed","status":"active","brandName":"E2Nomac","genericName":"E2Nomac","companyName":"Sydney Centre for Reproductive Health Research","companyId":"sydney-centre-for-reproductive-health-research","modality":"Small molecule","firstApprovalDate":"","aiSummary":"E2Nomac is a selective estrogen receptor modulator (SERM) that modulates estrogen signaling for reproductive health applications. Used for Reproductive health applications (specific indication not publicly detailed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}