{"id":"e2020-donepezil-hydrochloride","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1678","moleculeType":"Small molecule","molecularWeight":"415.96"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting the enzyme acetylcholinesterase, donepezil hydrochloride prevents the breakdown of acetylcholine, a neurotransmitter involved in memory and learning. This leads to an increase in acetylcholine levels in the brain, which can help to improve cognitive symptoms in patients with Alzheimer's disease. However, the exact mechanism of action is not fully understood and may involve other neurotransmitter systems as well.","oneSentence":"Donepezil hydrochloride is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:36:06.073Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe dementia of the Alzheimer's type"}]},"trialDetails":[{"nctId":"NCT06903910","phase":"PHASE2","title":"Investigating the Cholinergic Contribution to Gait Dysfunction in Parkinson's Disease","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2024-11-01","conditions":"Parkinson Disease","enrollment":6},{"nctId":"NCT04661280","phase":"PHASE3","title":"Donepezil Versus Non-drug Treatment in Alzheimer's Disease.","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-02-10","conditions":"Alzheimer Disease, Early Onset","enrollment":240},{"nctId":"NCT07351773","phase":"NA","title":"Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease","status":"COMPLETED","sponsor":"Taizhou Second People's Hospital","startDate":"2025-01-26","conditions":"Alzheimer's Disease(AD), Cognitive Dysfunction","enrollment":40},{"nctId":"NCT03810794","phase":"NA","title":"Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease","status":"RECRUITING","sponsor":"Jian Pei,MD","startDate":"2019-03-01","conditions":"Alzheimer Disease, Cognitive Impairment","enrollment":180},{"nctId":"NCT06285240","phase":"PHASE1","title":"Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia Taking Stable Donepezil Treatment (MK-1167-007)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2024-03-28","conditions":"Alzheimer's Disease","enrollment":28},{"nctId":"NCT07208344","phase":"EARLY_PHASE1","title":"Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease","status":"RECRUITING","sponsor":"Anhui Provincial Hospital","startDate":"2025-07-31","conditions":"Alzheimer Disease (AD)","enrollment":30},{"nctId":"NCT05564169","phase":"PHASE3","title":"Masitinib in Patients With Mild Alzheimer's Disease","status":"NOT_YET_RECRUITING","sponsor":"AB Science","startDate":"2026-06","conditions":"Alzheimer Disease","enrollment":600},{"nctId":"NCT05438264","phase":"EARLY_PHASE1","title":"Effect of Donepezil on Speech Recognition in Cochlear Implant Users","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2023-03-10","conditions":"Bilateral Sensorineural Hearing Loss","enrollment":50},{"nctId":"NCT05078944","phase":"NA","title":"Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture","status":"COMPLETED","sponsor":"Shanghai Institute of Acupuncture, Moxibustion and Meridian","startDate":"2022-06-30","conditions":"Alzheimer Disease 1","enrollment":160},{"nctId":"NCT05042102","phase":"PHASE2","title":"Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)","status":"RECRUITING","sponsor":"VA Connecticut Healthcare System","startDate":"2022-08-08","conditions":"Alcohol Use Disorder","enrollment":160},{"nctId":"NCT06041789","phase":"PHASE2","title":"Effect of Acetylcholinesterase Inhibitors on Bone Metabolism","status":"RECRUITING","sponsor":"Duke University","startDate":"2025-02-03","conditions":"Osteoporosis","enrollment":45},{"nctId":"NCT07153991","phase":"PHASE4","title":"Efficacy of Donepezil in Patients With Chronic Tinnitus","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Sao Paulo","startDate":"2021-11-19","conditions":"Tinnitus","enrollment":70},{"nctId":"NCT07153848","phase":"","title":"An Observational Study on Lecanemab Treatment for Early Alzheimer's Disease","status":"RECRUITING","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2024-07-01","conditions":"Alzheimer Disease","enrollment":400},{"nctId":"NCT07152418","phase":"","title":"Therapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET Research","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Alzheimer Disease (AD), Alzheimer Dementia, Mild Cognitive Impairment (MCI)","enrollment":120},{"nctId":"NCT02670161","phase":"PHASE4","title":"Quality Improvement and Practice Based Research in Neurology Using the EMR","status":"ENROLLING_BY_INVITATION","sponsor":"Endeavor Health","startDate":"2016-05","conditions":"Brain Tumors, Epilepsy, Migraine","enrollment":3300},{"nctId":"NCT07094438","phase":"PHASE1","title":"Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease","status":"RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2025-01-01","conditions":"Alzheimer Disease","enrollment":98},{"nctId":"NCT06871839","phase":"","title":"The Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's Disease","status":"RECRUITING","sponsor":"Cuibai Wei，Clinical Professor","startDate":"2025-03-10","conditions":"Alzheimer&#39;s Disease, Lecanemab, Functional Magnetic Resonance Imaging","enrollment":120},{"nctId":"NCT07066826","phase":"PHASE2, PHASE3","title":"Clinical Study to Evaluate the Efficacy and Safety of Huperzine A Controlled-Release Tablets in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type","status":"NOT_YET_RECRUITING","sponsor":"Wanbangde Pharmaceutical Group Co., LTD","startDate":"2025-08-01","conditions":"Alzheimer Dementia","enrollment":720},{"nctId":"NCT06518941","phase":"PHASE2","title":"An Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia Nervosa","status":"NOT_YET_RECRUITING","sponsor":"New York State Psychiatric Institute","startDate":"2026-06","conditions":"Anorexia Nervosa","enrollment":10},{"nctId":"NCT07060391","phase":"PHASE3","title":"A Prospective Multicenter RCT Study of Deep Jugular Lymphovenous Anastomosis in the Treatment of Alzheimer's Disease","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2025-07-31","conditions":"Alzheimer's Disease","enrollment":186},{"nctId":"NCT06417086","phase":"NA","title":"Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers","status":"RECRUITING","sponsor":"ZhanYJ","startDate":"2024-06-01","conditions":"Alzheimer Disease, Cognitive Impairment","enrollment":176},{"nctId":"NCT03740178","phase":"PHASE1","title":"Multiple Dose Trial of MK-4334 in Participants With Alzheimer's Clinical Syndrome (MK-4334-005)","status":"WITHDRAWN","sponsor":"Merck Sharp & Dohme LLC","startDate":"2019-09-27","conditions":"Alzheimer's Disease, Mild Cognitive Impairment","enrollment":""},{"nctId":"NCT05592678","phase":"NA","title":"δ in Dementia Clinical Trials","status":"RECRUITING","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2024-08-05","conditions":"Alzheimer's Disease (AD), Dementia, Cognitive Decline","enrollment":200},{"nctId":"NCT06840054","phase":"PHASE2","title":"The Safety and Efficacy of Sodium Pentaborate Pentahydrate in Patients With Mild to Moderate Alzheimer's Disease","status":"NOT_YET_RECRUITING","sponsor":"Tabriz University of Medical Sciences","startDate":"2025-05-01","conditions":"Alzheimer Disease","enrollment":30},{"nctId":"NCT06313866","phase":"NA","title":"the Clinical Effect of TCM Sniffing Therapy Combined With Electroacupuncture in PSCI","status":"RECRUITING","sponsor":"Hangzhou Medical College","startDate":"2024-04-01","conditions":"Stroke","enrollment":220},{"nctId":"NCT06828289","phase":"","title":"Rivastigmine Mini-Tablet for Alzheimer's Disease","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-02-28","conditions":"Alzheimer&#39;s Disease","enrollment":1000},{"nctId":"NCT04117178","phase":"PHASE4","title":"Monitoring Anti-Dementia Drugs by Serum Levels","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2020-02-04","conditions":"Dementia, Dementia With Lewy Bodies, Dementia in Parkinsons Disease","enrollment":132},{"nctId":"NCT02255799","phase":"PHASE3","title":"Multicenter Evaluation of Memory Remediation After TBI With Donepezil","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2013-09-01","conditions":"Traumatic Brain Injury, Memory Deficits","enrollment":75},{"nctId":"NCT06774261","phase":"PHASE1","title":"Phenserine on the Alzheimer's Treatment Horizon, Study 1","status":"NOT_YET_RECRUITING","sponsor":"Helse Stavanger HF","startDate":"2025-02-01","conditions":"Alzheimer Disease, Mild Cognitive Impairment","enrollment":16},{"nctId":"NCT05801380","phase":"","title":"Monitoring Drug Efficacy in Patients with Alzheimer's Disease","status":"RECRUITING","sponsor":"University of the Philippines","startDate":"2022-02-14","conditions":"Alzheimer Disease","enrollment":60},{"nctId":"NCT05345509","phase":"PHASE1, PHASE2","title":"A Clinical Trial to Access Pharmacokinetic Profiles and Safety of IVL3003.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Inventage Lab., Inc.","startDate":"2023-04-01","conditions":"Alzheimer Disease","enrollment":62},{"nctId":"NCT06687993","phase":"PHASE2","title":"Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier St Anne","startDate":"2024-11","conditions":"Anorexia Nervosa Restricting Type","enrollment":147},{"nctId":"NCT01406145","phase":"PHASE1","title":"A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"2011-06-16","conditions":"Alzheimer's Disease","enrollment":60},{"nctId":"NCT04730635","phase":"PHASE1","title":"Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2021-03-23","conditions":"Alzheimer's Disease, Mild Cognitive Impairment","enrollment":44},{"nctId":"NCT04617782","phase":"PHASE1","title":"Pharmacokinetic Study of 5 and 10 mg Corplex™ Donepezil TDS Compared to 10 mg Aricept® in Healthy Volunteers","status":"COMPLETED","sponsor":"Corium, Inc.","startDate":"2020-12-08","conditions":"Healthy Subjects","enrollment":60},{"nctId":"NCT02787746","phase":"PHASE4","title":"Safety and Efficacy of Donepezil in Mild to Moderate Alzheimer's Disease","status":"COMPLETED","sponsor":"Beijing Friendship Hospital","startDate":"2016-04","conditions":"Alzheimer's Disease","enrollment":241},{"nctId":"NCT02635750","phase":"PHASE1","title":"Investigation of Pharmacokinetic Drug-drug Interaction of BI 409306 and Donepezil in Healthy Male and Female Subjects","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2016-01-15","conditions":"Healthy","enrollment":32},{"nctId":"NCT04308304","phase":"PHASE1","title":"MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2021-02-16","conditions":"Alzheimer's Disease","enrollment":27},{"nctId":"NCT02626572","phase":"PHASE2","title":"Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms","status":"COMPLETED","sponsor":"Institut de Recherches Internationales Servier","startDate":"2015-02","conditions":"Alzheimer's Disease","enrollment":500},{"nctId":"NCT02487082","phase":"PHASE2","title":"Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders","status":"TERMINATED","sponsor":"Stony Brook University","startDate":"2015-06","conditions":"Autism Spectrum Disorder","enrollment":12},{"nctId":"NCT06393413","phase":"EARLY_PHASE1","title":"To Explore the Therapeutic Potential of Jiedu Yizhi Formula for Alzheimer 's Disease","status":"COMPLETED","sponsor":"Changchun University of Chinese Medicine","startDate":"2022-12-01","conditions":"Ensure the Legality and Compliance of the Testing Process","enrollment":62},{"nctId":"NCT06373094","phase":"PHASE1","title":"A Single Dose Escalation Study of HHT201 in Healthy Subjects","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Synergy Pharmaceutical Sciences Co., Ltd.","startDate":"2024-06-01","conditions":"Alzheimer Disease","enrollment":64},{"nctId":"NCT05976152","phase":"PHASE3","title":"Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)","status":"RECRUITING","sponsor":"Fudan University","startDate":"2024-04","conditions":"Stroke, Post-stroke Cognitive Impairment (PSCI)","enrollment":3200},{"nctId":"NCT01442766","phase":"PHASE1, PHASE2","title":"Donepezil Trial for Motor Recovery in Acute Stroke","status":"WITHDRAWN","sponsor":"Imperial College London","startDate":"2011-11","conditions":"Acute Stroke","enrollment":""},{"nctId":"NCT05254639","phase":"PHASE2","title":"Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2022-06-02","conditions":"Digestive Oncology, Supportive Care","enrollment":77},{"nctId":"NCT05383183","phase":"PHASE4","title":"Efficacy and Safety of ChOline ALfoscerate in Patient With Mild to Moderate Alzheimer's Disease","status":"RECRUITING","sponsor":"Daewoong Bio Inc.","startDate":"2022-01-20","conditions":"Alzheimer Disease","enrollment":630},{"nctId":"NCT06127368","phase":"PHASE1","title":"Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics From Single Dose of Intramuscular (IM) and Subcutaneous (SC) Donepezil (GB-5001) Injections Versus Donepezil Oral Tablet (Aricept®) in Healthy Male Volunteers","status":"UNKNOWN","sponsor":"G2GBio, Inc.","startDate":"2024-01-03","conditions":"Alzheimer Disease","enrollment":56},{"nctId":"NCT04507438","phase":"PHASE2","title":"The Effect of Donepezil on Glycemic Control in Type II Diabetics","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2019-07-12","conditions":"Diabetes Mellitus, Type 2","enrollment":7},{"nctId":"NCT03454646","phase":"PHASE4","title":"Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL)","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2024-06-01","conditions":"Alzheimer Disease, Cholinesterase Inhibitors","enrollment":1205},{"nctId":"NCT01872598","phase":"PHASE3","title":"Masitinib in Patients With Mild to Moderate Alzheimer's Disease","status":"COMPLETED","sponsor":"AB Science","startDate":"2012-01","conditions":"Alzheimer Disease","enrollment":721},{"nctId":"NCT05709301","phase":"PHASE2","title":"Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease","status":"UNKNOWN","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2023-10-01","conditions":"Parkinson Disease, Mild Cognitive Impairment","enrollment":120},{"nctId":"NCT05518409","phase":"NA","title":"Immunohistochemical Study of Neurodegenerative Diseases","status":"UNKNOWN","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2022-04-01","conditions":"Alzheimer Disease, Lewy Body Disease, Neurodegenerative Diseases","enrollment":100},{"nctId":"NCT02822573","phase":"PHASE3","title":"Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2017-05-30","conditions":"Cognitive Dysfunction, Memory Impairment","enrollment":276},{"nctId":"NCT02087865","phase":"PHASE4","title":"Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2014-05","conditions":"Genetic Risk for Alzheimer's Disease","enrollment":89},{"nctId":"NCT01251718","phase":"","title":"Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2010-12-01","conditions":"Alzheimer's Disease","enrollment":894},{"nctId":"NCT05525780","phase":"PHASE1","title":"Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Donepezil From Single Dose of GB-5001 IM Depot and Aricept® Oral Tablets in Healthy Male Volunteers","status":"COMPLETED","sponsor":"G2GBio, Inc.","startDate":"2022-08-26","conditions":"Alzheimer Disease","enrollment":48},{"nctId":"NCT01278407","phase":"PHASE3","title":"A Study of E2020 in Patients With Dementia With Lewy Bodies (DLB), Followed by a Long-term Extension Phase","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Dementia With Lewy Bodies (DLB)","enrollment":142},{"nctId":"NCT01539031","phase":"PHASE3","title":"Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2012-03","conditions":"Alzheimer's Type Dementia","enrollment":351},{"nctId":"NCT01843556","phase":"PHASE1","title":"A Phase 1 Study of E2022 Tape Formulation for Different Application Sites and Intervals in Japanese Healthy Elderly Males","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2012-12","conditions":"Healthy Elderly Male","enrollment":48},{"nctId":"NCT02580305","phase":"PHASE2","title":"SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study","status":"COMPLETED","sponsor":"Suven Life Sciences Limited","startDate":"2015-09","conditions":"Alzheimer's Disease","enrollment":564},{"nctId":"NCT04505670","phase":"PHASE2","title":"The Effect of Donepezil on Wound Healing","status":"UNKNOWN","sponsor":"University of Maryland, Baltimore","startDate":"2020-08-30","conditions":"Wound Heal","enrollment":20},{"nctId":"NCT05811000","phase":"PHASE2, PHASE3","title":"A Phase 2 Clinical Study to Explore the Optimal Dosage/Administration of PM012 Tablet in Alzheimer's Disease","status":"UNKNOWN","sponsor":"Mediforum Ltd., Co.","startDate":"2020-11-27","conditions":"Mild Alzheimer Disease","enrollment":312},{"nctId":"NCT05127746","phase":"PHASE1","title":"Phase 1 Clinical Trial of DA-5207 in Healthy Adults","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2021-11-25","conditions":"Healthy","enrollment":51},{"nctId":"NCT05804279","phase":"PHASE1","title":"Pharmacokinetics of BPDO-1603 or BPDO-16031 and BPDO-16033 Administration in Healthy Adults","status":"COMPLETED","sponsor":"Hyundai Pharm","startDate":"2022-12-28","conditions":"Healthy","enrollment":24},{"nctId":"NCT05641480","phase":"NA","title":"Technical R&D and Demonstration of Intelligent Medical Care in Alzheimer's Disease's Management","status":"UNKNOWN","sponsor":"Shaanxi Hospital of Traditional Chinese Medicine","startDate":"2022-06-03","conditions":"Alzheimer Disease, Subjective Cognitive Decline, Mild Cognitive Impairment","enrollment":150},{"nctId":"NCT05540977","phase":"EARLY_PHASE1","title":"Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy","status":"UNKNOWN","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2022-08-01","conditions":"Urinary Retention After Procedure","enrollment":108},{"nctId":"NCT05538507","phase":"PHASE2","title":"Efficacy of Chinese Traditional Medicine \"Smart Soup\" in Cognition and Behavior Regulation in Alzheimer's Disease","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2022-06-01","conditions":"Alzheimer Disease, Mild Cognitive Impairment","enrollment":180},{"nctId":"NCT03954613","phase":"PHASE4","title":"Evaluation of the Contribution of Regular Cognitive Exercises to Treatment in Patients With Alzheimer's Disease","status":"UNKNOWN","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2020-10-15","conditions":"Alzheimer Disease, Cognitive Change","enrollment":198},{"nctId":"NCT00151398","phase":"PHASE2","title":"Study Evaluating Lecozotan SR in Mild to Moderate Alzheimer's Disease (AD)","status":"COMPLETED","sponsor":"Wyeth is now a wholly owned subsidiary of Pfizer","startDate":"2005-10-06","conditions":"Alzheimer Disease","enrollment":229},{"nctId":"NCT04732182","phase":"NA","title":"Telerehabilitation Alzheimer's Disease Feasibility (TADF)","status":"UNKNOWN","sponsor":"Bright Cloud International Corp","startDate":"2022-02-16","conditions":"Alzheimer Disease, Healthy Aging","enrollment":14},{"nctId":"NCT05321680","phase":"NA","title":"Withdrawal of Antidementia Drugs in Advanced Dementia (WADAD)","status":"COMPLETED","sponsor":"Centro Hospitalar De São João, E.P.E.","startDate":"2021-03-01","conditions":"Dementia","enrollment":16},{"nctId":"NCT00688376","phase":"PHASE3","title":"Efficacy and Safety of Donepezil Hydrochloride in Preadolescent and Adolescent Children With Attention Impairment Following Cancer Treatment","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2008-07-02","conditions":"Attention Impairment","enrollment":72},{"nctId":"NCT00381381","phase":"PHASE4","title":"The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease","status":"COMPLETED","sponsor":"Eisai Korea Inc.","startDate":"2006-05-31","conditions":"Alzheimer's Disease","enrollment":199},{"nctId":"NCT00165724","phase":"PHASE4","title":"Alzheimer's Disease Long-term Follow-up Study (ALF Study)","status":"COMPLETED","sponsor":"Eisai Korea Inc.","startDate":"2004-06-30","conditions":"Alzheimer's Disease","enrollment":114},{"nctId":"NCT00566501","phase":"PHASE3","title":"Open-Label Extension Study of 23 mg Donepezil SR in Participants With Moderate to Severe Alzheimer's Disease","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2007-12-14","conditions":"Alzheimer's Disease","enrollment":915},{"nctId":"NCT05114499","phase":"","title":"Efficacy and Safety of Donepezil and Sodium Oligomannate in Patients With Mild to Moderate Alzheimer's Disease","status":"UNKNOWN","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2021-12","conditions":"Alzheimer Disease","enrollment":150},{"nctId":"NCT00477659","phase":"PHASE4","title":"Neural Correlates In Mild Alzheimer's Disease","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2007-07-23","conditions":"Alzheimer's Disease","enrollment":14},{"nctId":"NCT05102045","phase":"NA","title":"The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease","status":"COMPLETED","sponsor":"Istanbul Medipol University Hospital","startDate":"2016-09-01","conditions":"Alzheimer Disease","enrollment":27},{"nctId":"NCT00916383","phase":"PHASE2","title":"Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System","status":"COMPLETED","sponsor":"Teikoku Pharma USA, Inc.","startDate":"2009-05","conditions":"Irritation/Irritant","enrollment":49},{"nctId":"NCT01466270","phase":"PHASE2","title":"Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2012-07","conditions":"Anxiety Disorder, Breast Cancer, Cognition Disorders","enrollment":62},{"nctId":"NCT00369785","phase":"PHASE3","title":"Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2008-02","conditions":"Brain Tumors, Metastatic Disease","enrollment":198},{"nctId":"NCT01521117","phase":"PHASE4","title":"The Effect of Donepezil on Gait and Balance in Parkinson's Disease","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2011-12","conditions":"Parkinson's Disease","enrollment":21},{"nctId":"NCT00070161","phase":"PHASE2","title":"Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2001-07-01","conditions":"Brain and Central Nervous System Tumors, Radiation Toxicity","enrollment":68},{"nctId":"NCT03565809","phase":"","title":"Quality of the Management of Diabetes in Elderly People With Dementia in France","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2017-05-02","conditions":"Alzheimer Disease","enrollment":87816},{"nctId":"NCT03221894","phase":"","title":"A Retrospective Study to Investigate the Additive Effectiveness of Chinese Herbal Medicine in Alzheimer's Disease","status":"COMPLETED","sponsor":"Dongzhimen Hospital, Beijing","startDate":"2017-07-15","conditions":"Alzheimer Disease","enrollment":120},{"nctId":"NCT05003063","phase":"EARLY_PHASE1","title":"Effects of Acetylcholine and Attention on Visual Spatial Representations in the Brain","status":"COMPLETED","sponsor":"University of California, Berkeley","startDate":"2021-02-04","conditions":"Visual Perception, Attention, Information Processing","enrollment":12},{"nctId":"NCT00805792","phase":"PHASE2","title":"Mayo Acute Stroke Trial for Enhancing Recovery","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2008-11","conditions":"Ischemic Stroke","enrollment":33},{"nctId":"NCT00951834","phase":"PHASE2, PHASE3","title":"Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2009-10","conditions":"Alzheimer's Disease","enrollment":21},{"nctId":"NCT01584076","phase":"PHASE1","title":"Treatment of Residual Amblyopia With Donepezil","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2012-08","conditions":"Amblyopia","enrollment":18},{"nctId":"NCT00570128","phase":"PHASE2","title":"Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2007-11-16","conditions":"Down Syndrome","enrollment":129},{"nctId":"NCT04479865","phase":"PHASE1","title":"Phase 1 Clinical Trial to Evaluate the Safety, PK and PD of DA-5207 TDS in Healthy Adults","status":"UNKNOWN","sponsor":"Dong-A ST Co., Ltd.","startDate":"2020-07-28","conditions":"Healthy","enrollment":49},{"nctId":"NCT04013477","phase":"PHASE1","title":"Single-ascending Dose Phase 1 Clinical Trial to Evaluate the Safety and PK of DA-5207 TDS in Healthy Adults","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2019-06-18","conditions":"Healthy","enrollment":40},{"nctId":"NCT00675025","phase":"PHASE2","title":"Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial","status":"TERMINATED","sponsor":"Eisai Inc.","startDate":"2008-04-04","conditions":"Down Syndrome","enrollment":117},{"nctId":"NCT01743976","phase":"PHASE4","title":"Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain","status":"TERMINATED","sponsor":"Wake Forest University","startDate":"2012-12","conditions":"Neuropathic Pain","enrollment":5},{"nctId":"NCT03905096","phase":"PHASE1","title":"A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2019-04-12","conditions":"Healthy","enrollment":32},{"nctId":"NCT00457769","phase":"PHASE1","title":"Aricept to Improve Functional Tasks in Vascular Dementia","status":"UNKNOWN","sponsor":"Kessler Foundation","startDate":"2007-05","conditions":"Stroke, Vascular Dementia, Memory Deficits","enrollment":18},{"nctId":"NCT03197740","phase":"PHASE3","title":"A Multinational, Multi-center, Randomized, Double-blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer's Disease","status":"COMPLETED","sponsor":"Icure Pharmaceutical Inc.","startDate":"2017-10-12","conditions":"Alzheimer Disease","enrollment":399},{"nctId":"NCT03073876","phase":"PHASE4","title":"Detecting an Early Response to Donepezil With Measures of Visual Attention","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2005-12-01","conditions":"Alzheimer Disease","enrollment":25},{"nctId":"NCT02573519","phase":"NA","title":"Gastrointestinal Motility Among Diabetes Patients","status":"TERMINATED","sponsor":"University of Aarhus","startDate":"2015-10","conditions":"Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus","enrollment":40},{"nctId":"NCT04423276","phase":"PHASE4","title":"Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2020-06-14","conditions":"Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced, Protrusion of Intervertebral Disc","enrollment":360}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":59134,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"E2020-Donepezil hydrochloride","genericName":"E2020-Donepezil hydrochloride","companyName":"Eisai Co., Ltd.","companyId":"eisai","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Donepezil hydrochloride is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function in patients with Alzheimer's disease. Used for Moderate to severe dementia of the Alzheimer's type.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}