{"id":"e-coli-asparaginase","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Pancreatitis"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Coagulopathy"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Neurotoxicity"}]},"_chembl":null,"_fixedAt":"2026-03-30T13:52:02.035670","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Asparaginase is an enzyme derived from E. coli that catalyzes the hydrolysis of asparagine to aspartic acid and ammonia. Acute lymphoblastic leukemia (ALL) cells are often auxotrophic for asparagine and depend on circulating asparagine for survival and proliferation. By depleting systemic asparagine levels, the enzyme selectively inhibits protein synthesis in leukemic blasts while normal cells can synthesize asparagine endogenously.","oneSentence":"E. coli asparaginase depletes the amino acid asparagine in the bloodstream, starving leukemic cells that cannot synthesize their own asparagine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:17.296Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Acute myeloid leukemia (AML)"}]},"_fixedFields":["modality→Biologic"],"trialDetails":[{"nctId":"NCT06317662","phase":"PHASE2","title":"Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2025-06-05","conditions":"Acute 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Used for Acute lymphoblastic leukemia (ALL), Acute myeloid leukemia (AML).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}