{"id":"dysport-r","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Injection site pain or bruising"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Muscle weakness or paralysis (off-target)"},{"rate":"1-5","effect":"Ptosis (eyelid drooping)"},{"rate":"1-5","effect":"Dry mouth"},{"rate":"1-3","effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL89731","moleculeType":"Small molecule","molecularWeight":"159.14"},"_fixedAt":"2026-03-30T13:51:50.260174","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dysport contains botulinum toxin type A, which cleaves SNARE proteins required for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, leading to temporary paralysis of injected muscles. The effect is reversible as the body gradually regenerates the cleaved proteins over several months.","oneSentence":"Dysport is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:08.028Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Glabellar lines (aesthetic indication)"},{"name":"Spasticity associated with stroke or cerebral palsy"}]},"_fixedFields":["pubmed(9)"],"trialDetails":[{"nctId":"NCT06356025","phase":"PHASE4","title":"Botulinum Toxin Injection in the UES for R-CPD","status":"ACTIVE_NOT_RECRUITING","sponsor":"AZ Delta","startDate":"2024-09-02","conditions":"Retrograde Cricopharyngeus Dysfunction","enrollment":50},{"nctId":"NCT03848143","phase":"PHASE2","title":"Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain","status":"COMPLETED","sponsor":"Isabel Moreno Hay","startDate":"2019-09-11","conditions":"Neuropathic Pain","enrollment":10},{"nctId":"NCT06956729","phase":"NA","title":"Multicenter Trial of Proximal Femoral Guided Growth in Children With CP and Hips at Risk of Dislocation (GGSH-MC)","status":"RECRUITING","sponsor":"Fundación para la investigación biomética Hospital Infantil Universitario Niño Jesús","startDate":"2024-10-01","conditions":"Cerebral Palsy","enrollment":42},{"nctId":"NCT05006417","phase":"PHASE4","title":"Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome","status":"TERMINATED","sponsor":"University of Wisconsin, Madison","startDate":"2022-11-23","conditions":"Compartment Syndrome of Leg","enrollment":1},{"nctId":"NCT06437899","phase":"NA","title":"Evaluation of Efficacy and Patient Satisfaction of Local Anaesthesia Versus Sedoanalgesia for Botox (R) Injection in the Urinary Bladder for the Treatment of Idiopathic Overactive Bladder","status":"ENROLLING_BY_INVITATION","sponsor":"Hospital LKH Hochsteiermark - Leoben","startDate":"2023-09-01","conditions":"Overactive Bladder","enrollment":84},{"nctId":"NCT06126523","phase":"NA","title":"Effect of ESWT Applied After Botulinum Toxin Injection on Ankle Spasticity in Stroke Patients.","status":"UNKNOWN","sponsor":"Saglik Bilimleri Universitesi","startDate":"2023-12-01","conditions":"Stroke, Spasticity as Sequela of Stroke","enrollment":30},{"nctId":"NCT03805152","phase":"PHASE3","title":"Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2019-10-25","conditions":"Cervical Dystonia","enrollment":52},{"nctId":"NCT01050114","phase":"PHASE3","title":"OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER","status":"UNKNOWN","sponsor":"Christopher Patrick Smith","startDate":"2013-08","conditions":"Overactive Bladder","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"recentPublications":[{"date":"2010 Jun","pmid":"20359934","title":"Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia.","journal":"Parkinsonism & related disorders"},{"date":"2008 Oct 23","pmid":"18947418","title":"Study design and methods of the BoTULS trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A.","journal":"Trials"},{"date":"2004 Oct 30","pmid":"17618218","title":"Treatment of spasticity with botulinum toxin.","journal":"Ortopedia, traumatologia, rehabilitacja"},{"date":"2003","pmid":"14530623","title":"Is the reduction of spasticity by botulinum toxin a beneficial for the recovery of motor function of arm and hand in stroke patients?","journal":"European neurology"},{"date":"2002 Jul 10","pmid":"12171641","title":"The effects of botulinum toxin treatment on associated reactions of the upper limb on hemiplegic gait--a pilot study.","journal":"Disability and rehabilitation"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dysport (R)","genericName":"Dysport (R)","companyName":"Department of Medical Services Ministry of Public Health of Thailand","companyId":"department-of-medical-services-ministry-of-public-health-of-thailand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dysport is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}