{"id":"dydrogesterone-m-case-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Breast tenderness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dydrogesterone is a retro-isomer of norethisterone with selective progesterone receptor agonist activity. It mimics the effects of endogenous progesterone, promoting endometrial secretion and maintaining uterine quiescence during pregnancy. It is used to prevent miscarriage and support luteal insufficiency in women with threatened or recurrent pregnancy loss.","oneSentence":"Dydrogesterone is a synthetic progestin that binds to progesterone receptors to support luteal phase function and maintain pregnancy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:55.414Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Threatened miscarriage"},{"name":"Recurrent miscarriage due to luteal insufficiency"},{"name":"Habitual abortion"}]},"trialDetails":[{"nctId":"NCT02620345","phase":"PHASE4","title":"Fibroids in Women of Reproductive Age and Women Pregnancy","status":"COMPLETED","sponsor":"Trieu, Nguyen Thi, M.D.","startDate":"2010-01","conditions":"Fibroids","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dydrogesterone M"],"phase":"marketed","status":"active","brandName":"Dydrogesterone M ( case 1 )","genericName":"Dydrogesterone M ( case 1 )","companyName":"Trieu, Nguyen Thi, M.D.","companyId":"trieu-nguyen-thi-m-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dydrogesterone M (case 1) is being studied in a clinical trial for the treatment of fibroids in women of reproductive age and women in pregnancy. The study, identified as NCT02620345, is investigating the safety of combining Dydrogesterone M with a multivitamin for this condition.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}