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Flammable: Keep away from fire or flame. Do not use in the eyes over large areas of the body longer than 1 week unless directed by a doctor Ask a doctor before use if you have deep or puncture wounds animal bites serious burns Stop use and ask a doctor if conditions persists or gets worse infection occurs symptoms persist for than 7 days or clear up and occur again within a few days Keep out of reach of children. If swallowed, get medical help or call a Poison Control Center right away."],"questions":["Questions Call 1-866-964-0939"],"ask_doctor":["Ask a doctor before use if you have deep or puncture wounds animal bites serious burns"],"do_not_use":["Do not use in the eyes over large areas of the body longer than 1 week unless directed by a doctor"],"effective_time":"20251007","active_ingredient":["Active ingredients Benzethonium chloride 0.2% Dyclonine hydrochloride 0.75%"],"inactive_ingredient":["Inactive ingredients acetone, amyl acetate, castor oil, ethyl acetate, nitrocellulose, SD slcohol 40"],"indications_and_usage":["Uses first aid to prevent bacterial contamination in minor cuts, scrapes and burns for the temporary relief of pain in minor cuts, scrapes, and burns"],"safe_handling_warning":["Flammable: Keep away from fire or flame."],"other_safety_information":["Other information cap bottle tightly wipe top of bottle clean after each use store between 20° to 25°C (68° to 77°F) may temporarily sting upon application to remove, apply more Liquid Bandage and quickly wipe off do not allow to come into contact with fabrics, floors, counterops or other surfaces -- will stain."],"dosage_and_administration":["Directions for adults and children 2 years of age and older clean affected area apply a small amount on the area 1 to 3 times daily and let dry may be covered with a sterile bandage if bandaged, let dry first children under under 2 years of age; do not sure, consult a doctor"],"spl_product_data_elements":["Liquid Bandage Benzethonium chloride Plus Dyclonine hydrochloride ACETONE AMYL ACETATE CASTOR OIL ETHYL ACETATE PYROXYLIN ALCOHOL BENZETHONIUM CHLORIDE BENZETHONIUM DYCLONINE HYDROCHLORIDE DYCLONINE"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or call a Poison Control Center right away."],"package_label_principal_display_panel":["Principal Display Panel MEIJER For small cuts & wounds liquid bandage BENZETHONIUM CHLORIDE 0.2%/FIRST AID ANTISEPTIC DYCLONINE HYDROCHLORIDE 0.75%/TOPICAL ANALGESIC KILLS 99.9% OF GERMS TO HELP PREVENT INFECTION ​NET 0.3 FL OZ (9mL) image 1"]},"tags":[{"label":"dyclonine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholinesterase","category":"target"},{"label":"ACHE","category":"gene"},{"label":"SCN10A","category":"gene"},{"label":"N01BX02","category":"atc"},{"label":"Topical","category":"route"},{"label":"Oral","category":"route"},{"label":"Cream","category":"form"},{"label":"Liquid","category":"form"},{"label":"Lozenge","category":"form"},{"label":"Patch","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Active","category":"status"},{"label":"Itching of skin","category":"indication"},{"label":"Local anesthesia","category":"indication"},{"label":"Minor Skin Wound Pain","category":"indication"},{"label":"Mouth Irritation","category":"indication"},{"label":"Prevent Minor Bacterial Skin Infection","category":"indication"},{"label":"Skin irritation","category":"indication"},{"label":"Anesthetics","category":"pharmacology"},{"label":"Anesthetics, Local","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"INFECTION","source":"FDA FAERS","actionTaken":"70 reports"},{"date":"","signal":"ARTHRALGIA","source":"FDA FAERS","actionTaken":"65 reports"},{"date":"","signal":"WHITE BLOOD CELL COUNT DECREASED","source":"FDA FAERS","actionTaken":"45 reports"},{"date":"","signal":"PRODUCTIVE COUGH","source":"FDA FAERS","actionTaken":"44 reports"},{"date":"","signal":"PLATELET COUNT DECREASED","source":"FDA FAERS","actionTaken":"43 reports"},{"date":"","signal":"BLOOD MAGNESIUM DECREASED","source":"FDA FAERS","actionTaken":"40 reports"},{"date":"","signal":"CLOSTRIDIUM DIFFICILE INFECTION","source":"FDA FAERS","actionTaken":"40 reports"},{"date":"","signal":"FEBRILE NEUTROPENIA","source":"FDA FAERS","actionTaken":"40 reports"},{"date":"","signal":"HEART RATE ABNORMAL","source":"FDA FAERS","actionTaken":"40 reports"},{"date":"","signal":"HYPOTENSION","source":"FDA FAERS","actionTaken":"40 reports"}],"commonSideEffects":[],"contraindications":["Bleeding hemorrhoids","Conduction disorder of the heart","Decreased respiratory function","Denuded skin","Disorder of mucous membrane","Open wound","Seizure disorder"],"specialPopulations":{"Pregnancy":"Pregnancy Category C. Animal reproduction studies have not been conducted with dyclonine hydrochloride. It is also not known whether dyclonine hydrochloride can cause fetal harm when administered to pregnant woman or can affect reproduction capacity. Dyclonine hydrochloride should be given to pregnant women only if clearly needed.","Paediatric use":"Safety and effectiveness in children under the age of 12 have not been established."}},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DYCLONINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:50:12.889246+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:50:18.375749+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:50:12.002528+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DYCLONINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:50:18.781760+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:50:11.547315+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:50:11.547345+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:50:20.402107+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201217/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:50:19.495504+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M003","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:50:11.547348+00:00"}},"allNames":"dyclone","offLabel":[],"synonyms":["dyclonine","dyclonine hydrochloride","dyclocaine","dyclonin","dyclonine HCl"],"timeline":[{"date":"2018-11-20","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 1 manufacturer approved"}],"aiSummary":"Dyclonine (DYCLONINE) is a small molecule drug that targets acetylcholinesterase. It is used to treat various conditions including itching of the skin, local anesthesia, minor skin wound pain, mouth irritation, and skin irritation. The current owner of Dyclonine is AstraZeneca, and it is off-patent with no active Orange Book patents. As a result, there is a generic manufacturer available. 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reversible inhibitor of acetylcholinesterase, thereby increasing the concentration of acetylcholine in the synaptic cleft and enhancing its analgesic and anti-inflammatory effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/974","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DYCLONINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DYCLONINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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