{"id":"duragesic-reference-fentanyl-tds","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Dizziness"},{"rate":"15-20","effect":"Somnolence"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Respiratory depression"},{"rate":"10-15","effect":"Application site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and modulating pain perception. The transdermal delivery system (Duragesic patch) provides sustained-release fentanyl over 72 hours, maintaining steady-state plasma concentrations for chronic pain management. TDS (three times daily) dosing refers to the typical patch replacement schedule.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:47.951Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain in opioid-tolerant patients"},{"name":"Cancer pain"},{"name":"Severe chronic non-cancer pain"}]},"trialDetails":[{"nctId":"NCT02486016","phase":"PHASE4","title":"Transdermal Patch CVD 2000: The Effect of Heat on Fentanyl Release From Fentanyl TDSs in Healthy Adults","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2015-07-09","conditions":"Peer Review, Research","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brand name fentanyl TDS"],"phase":"marketed","status":"active","brandName":"Duragesic reference fentanyl TDS","genericName":"Duragesic reference fentanyl TDS","companyName":"University of Maryland, Baltimore","companyId":"university-of-maryland-baltimore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Chronic pain in opioid-tolerant patients, Cancer pain, Severe chronic non-cancer pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}