{"id":"dulox-capsule-60mg","brandName":"Dulox capsule (60mg)","genericName":"Dulox capsule (60mg)","companyId":"ain-shams-university","companyName":"Ain Shams University","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Dulox was presented as CYMBALTA® capsules manufactured by Lilly del Caribe Inc."],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Dulox capsule (60mg) is a small molecule neurokinin 1 receptor antagonist used to treat postoperative pain control. It belongs to the antagonist drug class and targets the substance-P receptor.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that blocks the reuptake transporters for both serotonin and norepinephrine, leading to increased neurotransmitter concentrations in the synaptic cleft. This dual mechanism enhances monoaminergic neurotransmission and is thought to improve mood regulation and pain perception. The drug is used primarily for depression, anxiety disorders, and chronic pain conditions.","oneSentence":"Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system, increasing their availability at synaptic sites.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"20-25","effect":"Nausea"},{"rate":"10-15","effect":"Dizziness"},{"rate":"10-12","effect":"Somnolence"},{"rate":"8-10","effect":"Dry mouth"},{"rate":"8-10","effect":"Fatigue"},{"rate":"8-10","effect":"Constipation"},{"rate":"5-8","effect":"Decreased appetite"},{"rate":"5-10","effect":"Sexual dysfunction"}]},"trials":[],"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Generalized anxiety disorder"},{"name":"Diabetic peripheral neuropathic pain"},{"name":"Fibromyalgia"},{"name":"Chronic musculoskeletal pain"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}