{"id":"duavive-0-45mg-20mg-tablet","safety":{"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Nonsteroidal anti-inflammatory drugs (NSAIDs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Selective serotonin reuptake inhibitors (SSRIs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Serotonin-norepinephrine reuptake inhibitors (SNRIs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tricyclic antidepressants","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Monoamine oxidase inhibitors (MAOIs)","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Thrombolytics","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Antiplatelet drugs","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Heparin","action":"Monitor","effect":"Increased risk 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bleeding"},{"drug":"Mycophenolate mofetil","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Azathioprine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclophosphamide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Methotrexate","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Corticosteroids","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclosporine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tacrolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Sirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Everolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Temsirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Mycophenolate mofetil","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Azathioprine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclophosphamide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Methotrexate","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Corticosteroids","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclosporine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tacrolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Sirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Everolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Temsirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Mycophenolate mofetil","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Azathioprine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclophosphamide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Methotrexate","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Corticosteroids","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclosporine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tacrolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Sirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Everolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Temsirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Mycophenolate mofetil","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Azathioprine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclophosphamide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Methotrexate","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Corticosteroids","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cyclosporine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tacrolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Sirolimus","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Everolimus","action":"Monitor","effect":"Increased risk of bleeding"}],"commonSideEffects":[],"contraindications":["are allergic to estrogen, bazedoxifene, or any ingredients of the medication","are or may become pregnant","are breast feeding","have eye damage resulting from blood vessel disease of the eye, such as a partial or complete loss of vision","have, have had, or may have breast cancer","have liver disease","have a history of heart attack, coronary heart disease or stroke caused by a blood clot","have or have had thrombophlebitis or thromboembolic disorders (blood clotting problems) such as a blood clot in the","have certain hereditary blood clotting disorders (e.g., protein C, protein S, or antithrombin deficiency)","have or have had overgrowth of the endometrium","have or may have a tumour dependent on estrogen","have undiagnosed abnormal vaginal bleeding"],"specialPopulations":{"Pregnancy":"This medicine is for use only by postmenopausal women with a uterus. Do not take this medicine if you are pregnant, or if you think you might be pregnant. Do not take this medicine if you are breast-feeding. Duavive is only for use in postmenopausal women, and is contraindicated in women who are or may become pregnant.","Geriatric use":"#### Elderly.  S, or antithrombin deficiency, see Section 4.4 Special Warnings and Precautions for Use).","Paediatric use":"There is no relevant use of Duavive in the paediatric population. Do not give DUAVIVE to a child. This medicine is not suitable for use in children.","Renal impairment":"The pharmacokinetics of CE/ bazedoxifene have not been evaluated in patients with renal impairment. Patients with renal impairment should be closely monitored since it is expected that the level of circulating estrogens components of Duavive will be increased. Use in this population is not recommended.","Hepatic impairment":"The safety and efficacy of CE/ bazedoxifene have not been evaluated in patients with hepatic impairment. Use in this population is not recommended."}},"company":"Pfizer","_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=duavive-0-45mg-20mg-tablet","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:49:01.112203+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:49:07.136551+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:49:01.180018+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=duavive-0-45mg-20mg-tablet","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:49:07.502586+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL411793/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:49:08.643956+00:00"}},"allNames":"duavive 0.45mg-20mg tablet","timeline":[],"aiSummary":"Duavive 0.45Mg-20Mg Tablet is a marketed drug by Pfizer Inc. for moderate to severe vasomotor symptoms associated with menopause. It has a significant commercial presence with $21.2B revenue. The exact mechanism of Duavive is not specified on Wikipedia. Duavive is a treatment option for menopausal symptoms, but its clinical differentiation and pipeline developments are not available. The commercial significance of Duavive is substantial due to its revenue. Further information on Duavive's mechanism and pipeline is required for a comprehensive understanding.","brandName":"Duavive 0.45Mg-20Mg Tablet","isGeneric":true,"mechanism":{"target":"estrogen receptors","novelty":"best-in-class","modality":"small molecule","drugClass":"estrogen receptor modulator","explanation":"","oneSentence":"","technicalDetail":"The mechanism of Duavive involves the modulation of estrogen receptors to alleviate vasomotor symptoms associated with menopause. However, the exact molecular targets and pharmacological classes involved are not specified. Further research is required to determine the technical details of Duavive's mechanism."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"commercial":{"yoyGrowth":"7","annualCostUS":"$80,000/yr","genericStatus":"Generic — off-patent","currentRevenue":"$21.2B","peakSalesEstimate":"$21.2B"},"references":[{"id":1,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=duavive-0-45mg-20mg-tablet","fields":["publications"],"source":"PubMed/NCBI"},{"id":2,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":3,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":4,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:49:10.330409+00:00","fieldsConflicting":2,"overallConfidence":0.8},"_whoChecked":true,"competitors":[{"name":"Prempro","company":"Conjugated Estrogens/Medroxyprogesterone","advantage":"May cause progestin-related side effects like breast tenderness, bloating, and mood changes"},{"name":"Bijuva","company":"Estradiol/Progesterone","advantage":"Best for: Women who need flexible dosing or whose doctors want to adjust each component independently"},{"name":"Activella","company":"Estradiol/Norethindrone Acetate","advantage":"Best for: Women who need flexible dosing or whose doctors want to adjust each component independently"},{"name":"Premarin + Provera","company":"Separate pills, flexible dosing, generics available","advantage":"$20–$80/month"},{"name":"Bijuva","company":"Bioidentical estradiol + progesterone, brand-only","advantage":"$200–$400/month"},{"name":"Prempro","company":"Estrogen + progestin, generic available","advantage":"$15–$50/month"},{"name":"Activella","company":"Estradiol + progestin, generic available","advantage":"$20–$60/month"}],"genericName":"duavive-0-45mg-20mg-tablet","indications":{"approved":[{"name":"Treatment of moderate to severe vasomotor symptoms associated with menopause","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_mhraChecked":true,"_emaApprovals":[{"date":"","name":"Duavive 0.45Mg-20Mg Tablet","status":"Authorised","regulator":"EMA"}],"molecularData":{"oral":false,"chemblId":"CHEMBL411793","moleculeType":"Protein","molecularWeight":"1698.96"},"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"crossReferences":{"chemblId":"CHEMBL411793"},"_offLabelChecked":true,"publicationCount":0,"recentPublications":[],"_drugWebsiteChecked":true,"_healthCanadaChecked":true,"_genericFilersChecked":true,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"trialDetails":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","companyName":"Pfizer","companyId":"pfizer","modality":"small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":8,"regulatoryByCountry":[{"country_code":"EU","regulator":"EMA","status":"pending","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:49:10.330409+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}