{"id":"duac-gel-differin-gel","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Skin irritation/erythema"},{"rate":"10-25","effect":"Dryness"},{"rate":"5-20","effect":"Peeling/desquamation"},{"rate":"5-15","effect":"Photosensitivity"},{"rate":"5-15","effect":"Burning/stinging"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Duac® Gel works through dual action: clindamycin inhibits bacterial protein synthesis to kill Cutibacterium acnes, while benzoyl peroxide generates reactive oxygen species that further eliminate bacteria and prevent resistance. Differin® Gel's adapalene is a third-generation retinoid that binds retinoic acid receptors to regulate keratinocyte differentiation, reduce sebum production, and decrease inflammation. Together, these products address multiple pathogenic factors in acne.","oneSentence":"Duac® Gel combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and inflammation, while Differin® Gel contains adapalene (a retinoid) that normalizes skin cell turnover and reduces comedone formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:05.748Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris (Duac® Gel)"},{"name":"Acne vulgaris (Differin® Gel)"}]},"trialDetails":[{"nctId":"NCT00671749","phase":"PHASE4","title":"Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-12","conditions":"Acne Vulgaris","enrollment":100},{"nctId":"NCT00160394","phase":"PHASE4","title":"Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2004-12","conditions":"Acne Vulgaris","enrollment":130},{"nctId":"NCT01231334","phase":"PHASE4","title":"A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-08","conditions":"Acne Vulgaris","enrollment":286},{"nctId":"NCT00807014","phase":"PHASE4","title":"Evaluation of Quality of Life, Efficacy, and Tolerance of Duac® Gel Compared to Differin® Gel in the Treatment of Acne","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2006-11","conditions":"Acne Vulgaris","enrollment":169}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Duac® Gel / Differin® Gel","genericName":"Duac® Gel / Differin® Gel","companyName":"Stiefel, a GSK Company","companyId":"stiefel-a-gsk-company","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Duac® Gel combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to reduce acne-causing bacteria and inflammation, while Differin® Gel contains adapalene (a retinoid) that normalizes skin cell turnover and reduces comedone formation. Used for Acne vulgaris (Duac® Gel), Acne vulgaris (Differin® Gel).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}