{"id":"duac-fixed-dose-combination-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, while benzoyl peroxide generates reactive oxygen species that have bactericidal activity against Propionibacterium acnes. Together, they provide synergistic antimicrobial and anti-inflammatory effects on acne lesions.","oneSentence":"Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to kill acne-causing bacteria and reduce inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:43.973Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT02557399","phase":"PHASE4","title":"DUAC® Early Onset Efficacy Study in Japanese Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-10-07","conditions":"Acne Vulgaris","enrollment":350},{"nctId":"NCT01448733","phase":"PHASE4","title":"Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris","status":"UNKNOWN","sponsor":"Zeichner, Joshua, M.D.","startDate":"2011-07","conditions":"Acne Vulgaris","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Duac® fixed dose combination gel","genericName":"Duac® fixed dose combination gel","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Duac combines clindamycin (an antibiotic) and benzoyl peroxide (an antimicrobial oxidizing agent) to kill acne-causing bacteria and reduce inflammation. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}