{"id":"dtpw-hbv-hib-kft-vaccine-gsk323527a","safety":{"commonSideEffects":[{"rate":"10-50%","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"10-30%","effect":"Fever"},{"rate":"5-20%","effect":"Irritability"},{"rate":"5-15%","effect":"Drowsiness"},{"rate":"5-10%","effect":"Loss of appetite"}]},"_chembl":{"chemblId":"CHEMBL2108573","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DTPw-HBV/Hib is a pentavalent vaccine combining whole-cell pertussis (DTPw), hepatitis B surface antigen (HBV), and Haemophilus influenzae type b conjugate (Hib) components. It primes both humoral and cellular immunity by presenting multiple pathogen-derived antigens to the immune system, generating protective antibodies and T-cell responses against these five infectious diseases. The vaccine is administered in infancy to establish immunological memory before natural exposure to these pathogens.","oneSentence":"This combination vaccine stimulates immune responses against diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b through inactivated antigens and recombinant proteins.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:10.914Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Active immunization against diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b in infants and young children"}]},"trialDetails":[{"nctId":"NCT00332566","phase":"PHASE3","title":"Assess Immunogenicity, Reactogenicity, Safety of a Booster of GSK Biologicals DTPw-HBV/Hib Kft Compared to DTPw-HBV/Hib","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-06","conditions":"Hepatitis B, Whole Cell Pertussis, Tetanus","enrollment":148}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"DTPw-HBV/Hib Kft vaccine GSK323527A","genericName":"DTPw-HBV/Hib Kft vaccine GSK323527A","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"This combination vaccine stimulates immune responses against diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b through inactivated antigens and recombinant proteins. Used for Active immunization against diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b in infants and young children.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}