{"id":"dtap-ipv-mkc-vaccine","safety":{"commonSideEffects":[{"rate":"10-50","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Irritability or fussiness"},{"rate":"5-10","effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combination vaccine containing inactivated toxoids of diphtheria and tetanus, acellular pertussis antigens, and inactivated poliovirus particles. Upon administration, these antigens trigger both humoral (antibody) and cell-mediated immune responses, priming the immune system to recognize and neutralize these pathogens if encountered naturally. The 'mkc' designation likely refers to the manufacturing cell substrate or process used by Statens Serum Institut.","oneSentence":"DTaP-IPV mkc vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and poliovirus through inactivated antigens.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:09.137Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of diphtheria, tetanus, pertussis, and poliomyelitis in infants and children"}]},"trialDetails":[{"nctId":"NCT00655148","phase":"PHASE3","title":"Safety and Immunogenicity of a New Serum-free DTaP-IPVvero Combination Vaccine","status":"COMPLETED","sponsor":"Statens Serum Institut","startDate":"2003-09","conditions":"Active Immunization","enrollment":817}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"DTaP-IPV mkc vaccine","genericName":"DTaP-IPV mkc vaccine","companyName":"Statens Serum Institut","companyId":"statens-serum-institut","modality":"Biologic","firstApprovalDate":"","aiSummary":"DTaP-IPV mkc vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria, tetanus, pertussis, and poliovirus through inactivated antigens. Used for Prevention of diphtheria, tetanus, pertussis, and poliomyelitis in infants and children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}