{"id":"dt3ap-hbs-ipv","safety":{"commonSideEffects":[{"rate":"10-50","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"5-15","effect":"Fever"},{"rate":"5-20","effect":"Irritability or fussiness"},{"rate":"5-10","effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This pentavalent vaccine works by introducing inactivated or toxoid forms of five pathogens to stimulate both humoral and cellular immune responses. The diphtheria and tetanus components use toxoids (inactivated toxins), the acellular pertussis component uses purified bacterial antigens, the hepatitis B component uses recombinant surface antigen, and the inactivated polio vaccine provides protection against all three poliovirus serotypes. Together, these antigens prime the immune system to recognize and neutralize these pathogens upon natural exposure.","oneSentence":"DT3aP-HBs-IPV is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis through simultaneous administration of multiple antigens.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:09.119Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Primary immunization against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis in infants and children"}]},"trialDetails":[{"nctId":"NCT00355654","phase":"PHASE3","title":"Study to Compare Booster Vaccination With Pediacel® to Infanrix® Hexa When Both Are Co-Administered With Prevenar®","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2006-09","conditions":"Infant, Healthy","enrollment":847}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Infanrix® hexa"],"phase":"phase_3","status":"active","brandName":"DT3aP-HBs-IPV","genericName":"DT3aP-HBs-IPV","companyName":"Sanofi Pasteur, a Sanofi Company","companyId":"sanofi","modality":"Biologic","firstApprovalDate":"","aiSummary":"DT3aP-HBs-IPV is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis through simultaneous administration of multiple antigens. Used for Primary immunization against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis in infants and children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}