{"id":"dt-polio","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, erythema, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia or fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1629737","moleculeType":"Small molecule","molecularWeight":"537.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated or toxoid forms of diphtheria and tetanus antigens along with inactivated poliovirus particles. Upon administration, these antigens trigger both humoral and cellular immune responses, leading to the production of protective antibodies (primarily IgG) against these three pathogens. This provides immunological memory that protects against future exposure to wild-type diphtheria, tetanus, and poliovirus.","oneSentence":"DT-Polio is a combined diphtheria-tetanus-poliomyelitis vaccine that stimulates the immune system to produce antibodies against diphtheria toxin, tetanus toxin, and poliovirus.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:03.215Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of diphtheria, tetanus, and poliomyelitis in pediatric and adult populations"}]},"trialDetails":[{"nctId":"NCT00447525","phase":"PHASE3","title":"REVAXIS® Versus DT Polio® as a Second Booster in 6 Year-old Children","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2007-02","conditions":"Diphtheria, Tetanus, Poliomyelitis","enrollment":760}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"DT-Polio®","genericName":"DT-Polio®","companyName":"Sanofi Pasteur, a Sanofi Company","companyId":"sanofi","modality":"Biologic","firstApprovalDate":"","aiSummary":"DT-Polio is a combined diphtheria-tetanus-poliomyelitis vaccine that stimulates the immune system to produce antibodies against diphtheria toxin, tetanus toxin, and poliovirus. Used for Prevention of diphtheria, tetanus, and poliomyelitis in pediatric and adult populations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}