{"id":"ds-1062a","safety":{"commonSideEffects":[{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Anemia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DS-1062a combines a humanized anti-TROP-2 monoclonal antibody with a topoisomerase I inhibitor (SN-38 derivative) linked via a cleavable linker. Upon binding to TROP-2 expressed on tumor cells, the conjugate is internalized and the payload is released intracellularly, leading to DNA damage and apoptosis. This targeted approach aims to maximize efficacy while minimizing systemic toxicity.","oneSentence":"DS-1062a is an antibody-drug conjugate that targets TROP-2 on cancer cells and delivers a topoisomerase I inhibitor payload to induce cell death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:06.141Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced or metastatic non-small cell lung cancer"},{"name":"Advanced gastric or gastroesophageal junction cancer"}]},"trialDetails":[{"nctId":"NCT04484142","phase":"PHASE2","title":"Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05)","status":"COMPLETED","sponsor":"Daiichi Sankyo","startDate":"2021-03-30","conditions":"Non-small Cell Lung Cancer","enrollment":137},{"nctId":"NCT04656652","phase":"PHASE3","title":"Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer 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