{"id":"drug-yaz-flex-sh-t00186d","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Breakthrough bleeding"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"YAZ flex contains ethinyl estradiol (estrogen) and drospirenone (progestin with antimineralocorticoid activity). The hormones suppress the luteinizing hormone (LH) surge needed for ovulation and thicken cervical mucus to prevent sperm penetration. The flexible regimen allows users to adjust the number of active pills taken consecutively before the hormone-free interval, providing personalized cycle control.","oneSentence":"YAZ flex is an oral contraceptive that prevents ovulation through a combination of ethinyl estradiol and drospirenone, with a flexible dosing regimen.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:06.265Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception"},{"name":"Treatment of premenstrual dysphoric disorder (PMDD)"}]},"trialDetails":[{"nctId":"NCT00569244","phase":"PHASE3","title":"SH T00186 in the Treatment of Primary Dysmenorrhea","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-12","conditions":"Primary Dysmenorrhea","enrollment":223}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Drug: YAZ flex (SH T00186D)","genericName":"Drug: YAZ flex (SH T00186D)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"YAZ flex is an oral contraceptive that prevents ovulation through a combination of ethinyl estradiol and drospirenone, with a flexible dosing regimen. Used for Contraception, Treatment of premenstrual dysphoric disorder (PMDD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}