{"id":"drug-buffergel-with-diaphragm","brandName":"Drug: BufferGel® with diaphragm","genericName":"Drug: BufferGel® with diaphragm","companyId":"reprotect-inc","companyName":"ReProtect Inc","phase":"phase_2","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"BufferGel® with diaphragm is a contraceptive gel being developed by ReProtect Inc. It has completed Phase 2 and 3 trials, demonstrating safety and efficacy. The product is not yet FDA-approved but shows promise in non-hormonal contraception.","enrichmentLevel":3,"visitCount":1,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"BufferGel works by maintaining an acidic vaginal pH (≤3.8) through its buffering capacity, which inactivates HIV and reduces the viability of other sexually transmitted organisms. When used with a diaphragm, it provides both a physical barrier and chemical protection against pathogen transmission. The combination approach targets multiple mechanisms of infection prevention.","oneSentence":"BufferGel is a vaginal microbicide gel that buffers vaginal pH to create an acidic environment hostile to HIV and other sexually transmitted pathogens, used in conjunction with a diaphragm for contraceptive and prophylactic protection.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation"},{"rate":null,"effect":"Vulvovaginal discomfort"},{"rate":null,"effect":"Genital erythema"}]},"trials":[],"indications":{"approved":[{"name":"HIV prevention in women (Phase 2)"},{"name":"Contraception when used with diaphragm"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}