{"id":"droxidopa-oral-product","safety":{"commonSideEffects":[{"rate":"10%","effect":"Nausea"},{"rate":"8%","effect":"Headache"},{"rate":"6%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL2103827","moleculeType":"Small molecule","molecularWeight":"213.19"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Droxidopa is a synthetic amino acid that acts as a precursor to norepinephrine, increasing its levels in the central nervous system and stimulating noradrenergic neurons.","oneSentence":"Noradrenergic neuron stimulation","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:35:15.501Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neurogenic orthostatic hypotension"}]},"trialDetails":[{"nctId":"NCT07398508","phase":"PHASE1, PHASE2","title":"Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease.","status":"RECRUITING","sponsor":"Stephen G. Kaler","startDate":"2026-06-01","conditions":"Menkes Disease","enrollment":6},{"nctId":"NCT02897063","phase":"PHASE1","title":"Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2016-09","conditions":"Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy","enrollment":34},{"nctId":"NCT01370512","phase":"PHASE2","title":"Droxidopa / Pyridostigmine in Orthostatic Hypotension","status":"ENROLLING_BY_INVITATION","sponsor":"Mayo Clinic","startDate":"2011-11","conditions":"Orthostatic Hypotension","enrollment":30},{"nctId":"NCT06937307","phase":"PHASE2","title":"Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury","status":"RECRUITING","sponsor":"Giuseppe Cullaro, MD","startDate":"2025-05-27","conditions":"Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver","enrollment":75},{"nctId":"NCT00581477","phase":"PHASE2, PHASE3","title":"Treatment of Orthostatic Hypotension","status":"TERMINATED","sponsor":"Vanderbilt University","startDate":"2004-01","conditions":"Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency","enrollment":8},{"nctId":"NCT02812147","phase":"PHASE2","title":"Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease","status":"UNKNOWN","sponsor":"St. Joseph's Hospital and Medical Center, Phoenix","startDate":"2016-05","conditions":"Parkinson Disease","enrollment":20},{"nctId":"NCT00547911","phase":"PHASE1, PHASE2","title":"Augmenting Effects of L-DOPS With Carbidopa and Entacapone","status":"TERMINATED","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2007-10","conditions":"Parkinson Disease, Multiple System Atrophy, Autonomic Nervous System Diseases","enrollment":14},{"nctId":"NCT00738062","phase":"PHASE3","title":"Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)","status":"COMPLETED","sponsor":"Chelsea Therapeutics","startDate":"2008-01","conditions":"Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy, Multiple System Atrophy","enrollment":103}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NORTHERA","L-DOPS"],"phase":"phase_2","status":"active","brandName":"Droxidopa Oral Product","genericName":"Droxidopa Oral Product","companyName":"Stephen G. Kaler","companyId":"stephen-g-kaler","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Noradrenergic neuron stimulation Used for Neurogenic orthostatic hypotension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}