{"id":"droperidol-injectable-product","safety":{"commonSideEffects":[{"rate":null,"effect":"QT prolongation"},{"rate":null,"effect":"Dystonia"},{"rate":null,"effect":"Akathisia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Droperidol antagonizes dopamine D2 receptors, which suppresses psychomotor agitation and provides antiemetic activity through effects on the chemoreceptor trigger zone. It also has some alpha-adrenergic blocking properties. The drug is primarily used for acute agitation and postoperative nausea and vomiting in clinical settings.","oneSentence":"Droperidol is a butyrophenone antipsychotic that blocks dopamine receptors in the central nervous system, reducing agitation and providing antiemetic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:01.087Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute agitation and anxiety"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Chemotherapy-induced nausea and vomiting (CINV)"}]},"trialDetails":[{"nctId":"NCT05244460","phase":"PHASE3","title":"Droperidol on Prevention of Cannabis Hyperemesis Syndrome","status":"UNKNOWN","sponsor":"Mercy Health Ohio","startDate":"2021-12-02","conditions":"Cannabis Hyperemesis Syndrome","enrollment":45},{"nctId":"NCT03944681","phase":"NA","title":"Gender Influence on Torsadogenic Actions of Droperidol.","status":"COMPLETED","sponsor":"Medical University of Gdansk","startDate":"2019-04-23","conditions":"Arrhythmia, Droperidol","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inapsine"],"phase":"phase_3","status":"active","brandName":"Droperidol Injectable Product","genericName":"Droperidol Injectable Product","companyName":"Mercy Health Ohio","companyId":"mercy-health-ohio","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Droperidol is a butyrophenone antipsychotic that blocks dopamine receptors in the central nervous system, reducing agitation and providing antiemetic effects. Used for Acute agitation and anxiety, Postoperative nausea and vomiting (PONV), Chemotherapy-induced nausea and vomiting (CINV).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}