{"id":"droperidol","rwe":[{"pmid":"41777419","year":"2026","title":"From Limited Use to Standard Practice: Retrospective Analysis of Droperidol Administration by Emergency Medical Services (2018-2023).","finding":"","journal":"Open access emergency medicine : OAEM","studyType":"Clinical Study"},{"pmid":"41760406","year":"2026","title":"Prehospital management of acute behavioural disturbance: managing severe agitation in the prehospital setting - a systematic literature review.","finding":"","journal":"Emergency medicine journal : EMJ","studyType":"Clinical Study"},{"pmid":"41740194","year":"2026","title":"Intramuscular droperidol, olanzapine, midazolam, or lorazepam to treat methamphetamine intoxication in the emergency department.","finding":"","journal":"The American journal of emergency medicine","studyType":"Clinical Study"},{"pmid":"41628415","year":"2026","title":"Exogenous Sex Hormones and Postoperative Nausea and Vomiting Risk in Transgender Patients.","finding":"","journal":"Anesthesia and analgesia","studyType":"Clinical Study"},{"pmid":"41605419","year":"2026","title":"Cannabis hyperemesis syndrome: the rare case of a valid diagnosis plus hypersensitization hypothesis for development and chronification of this severe somatic cannabis use disorder.","finding":"","journal":"Fortschritte der Neurologie-Psychiatrie","studyType":"Clinical Study"}],"_fda":{"id":"8bcdfec0-1df7-413d-82c1-ac564d18aaa0","set_id":"147e033d-d997-4ef6-8bb5-a9ba372590b2","openfda":{"nui":["N0000175799","N0000175800"],"upc":["0305179702251"],"unii":["O9U0F09D5X"],"route":["INTRAMUSCULAR","INTRAVENOUS"],"rxcui":["282485"],"spl_id":["8bcdfec0-1df7-413d-82c1-ac564d18aaa0"],"brand_name":["Droperidol"],"spl_set_id":["147e033d-d997-4ef6-8bb5-a9ba372590b2"],"package_ndc":["0517-9702-25"],"product_ndc":["0517-9702"],"generic_name":["DROPERIDOL"],"product_type":["HUMAN PRESCRIPTION DRUG"],"substance_name":["DROPERIDOL"],"pharm_class_epc":["Dopamine-2 Receptor Antagonist [EPC]"],"pharm_class_moa":["Dopamine D2 Antagonists [MoA]"],"manufacturer_name":["American Regent, Inc."],"application_number":["ANDA072123"],"is_original_packager":[true]},"version":"8","warnings":["WARNINGS Droperidol should be administered with extreme caution in the presence of risk factors for development of prolonged QT syndrome, such as: 1) clinically significant bradycardia (less than 50 bpm), 2) any clinically significant cardiac disease, 3) treatment with Class I and Class III antiarrhythmics, 4) treatment with monoamine oxidase inhibitors (MAOI's), 5) concomitant treatment with other drug products known to prolong the QT interval (see PRECAUTIONS, Drug Interactions ), and 6) electrolyte imbalance, in particular hypokalemia and hypomagnesemia, or concomitant treatment with drugs (e.g., diuretics) that may cause electrolyte imbalance. Effects on Cardiac Conduction: A dose-dependent prolongation of the QT interval was observed within 10 minutes of droperidol administration in a study of 40 patients without known cardiac disease who underwent extracranial head and neck surgery. Significant QT prolongation was observed at all three dose levels evaluated, with 0.1, 0.175, and 0.25 mg/kg associated with prolongation of median QTc by 37,44, and 59 msec, respectively. Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes, ventricular arrhythmias, cardiac arrest, and death) have been observed during post-marketing treatment with droperidol. Some cases have occurred in patients with no known risk factors and at doses at or below recommended doses. There has been at least one case of nonfatal torsade de pointes confirmed by rechallenge. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, droperidol should NOT be administered. For patients in whom the potential benefit of droperidol treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2-3 hours after completing treatment to monitor for arrhythmias. FLUIDS AND OTHER COUNTERMEASURES TO MANAGE HYPOTENSION SHOULD BE READILY AVAILABLE. As with other CNS depressant drugs, patients who have received droperidol should have appropriate surveillance. It is recommended that opioids, when required, initially be used in reduced doses. As with other neuroleptic agents, very rare reports of neuroleptic malignant syndrome (altered consciousness, muscle rigidity and autonomic instability) have occurred in patients who have received droperidol. Since it may be difficult to distinguish neuroleptic malignant syndrome from malignant hyperpyrexia in the perioperative period, prompt treatment with dantrolene should be considered if increases in temperature, heart rate or carbon dioxide production occur."],"pregnancy":["Pregnancy Category C. Droperidol administered intravenously has been shown to cause a slight increase in mortality of the newborn rat at 4.4 times the upper human dose. At 44 times the upper human dose, mortality rate was comparable to that for control animals. Following intramuscular administration, increased mortality of the offspring at 1.8 times the upper human dose is attributed to CNS depression in the dams who neglected to remove placentae from their offspring. Droperidol has not been shown to be teratogenic in animals. There are no adequate and well-controlled studies in pregnant women. Droperidol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus."],"overdosage":["OVERDOSAGE Manifestations: The manifestations of droperidol overdosage are an extension of its pharmacologic actions and may include QT prolongation and serious arrhythmias (e.g., torsade de pointes) (see BOXED WARNING , WARNINGS , and PRECAUTIONS ). Treatment: In the presence of hypoventilation or apnea, oxygen should be administered and respiration should be assisted or controlled as indicated. A patent airway must be maintained; an oropharyngeal airway or endotracheal tube might be indicated. The patient should be carefully observed for 24 hours; body warmth and adequate fluid intake should be maintained. If hypotension occurs and is severe or persists, the possibility of hypovolemia should be considered and managed with appropriate parenteral fluid therapy. (see PRECAUTIONS ). If significant extrapyramidal reactions occur in the context of an overdose, an anticholinergic should be administered. The intravenous Median Lethal Dose of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular Median Lethal Dose of droperidol is 195 mg/kg in mice; 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs."],"references":["REFERENCES Saarnivaara L, Klemola UM, Lindgren L, et al. QT interval of the ECG, heart rate and arterial pressure using propofol, methohexital or midazolam for induction of anaesthesia. Acta Anaesthesiol Scand 1990: 34: 276-81. Schmeling WT, Warltier DC, McDonald DJ, et al. Prolongation of the QT interval by enflurane, isoflurane and halothane in humans. Anesth Analg 1991:72:137-44. Spath G. Torsade des pointe oder die andere Ursache des plotz-lichen Herztodes. Wien: Ueberreuter. 1998. Riley DC, Schmeling WT, al-Wathiqui MH, et al. Prolongation of the QT interval by volatile anesthetics in chronically instrumented dogs. Anesth Analg 1988: 67:741-9. McConachie I, Keaveny JP, Healy TE, et al. Effects of anaesthesia on the QT interval. Br J Anaesth 1989:63:558-60. Lawrence KR, Nasraway SA. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: a review of the literature. Pharmacother 1997: 17(3):531-7. Lischke V, Behne M, Doelken P, et al. Droperidol causes a dose-dependent prolongation of the QT interval. Anesth Analg 1994:79:983-6. AMERICAN REGENT, INC. SHIRLEY, NY 11967 IN9702 Rev. 1/09"],"description":["DESCRIPTION Droperidol Injection, USP, is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular use only. Each mL contains: Droperidol…………………………………….2.5 mg Water for Injection………………………........q.s. pH adjusted between 3.0 and 3.8 with lactic acid and, if necessary, with sodium hydroxide. Droperidol is a neuroleptic (tranquilizer) agent. Chemically it is 1-(1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone and the structural formula is: ad2af77a-figure-01"],"precautions":["PRECAUTIONS General The initial dose of droperidol should be appropriately reduced in elderly, debilitated and other poor-risk patients. The effect of the initial dose should be considered in determining incremental doses. Certain forms of conduction anesthesia, such as spinal anesthesia and some peridural anesthetics, can alter respiration by blocking intercostal nerves and can cause peripheral vasodilation and hypotension because of sympathetic blockade. Through other mechanisms (see CLINICAL PHARMACOLOGY ), droperidol can also alter circulation. Therefore, when droperidol is used to supplement these forms of anesthesia, the anesthetist should be familiar with the physiological alterations involved, and be prepared to manage them in the patients elected for these forms of anesthesia. If hypotension occurs, the possibility of hypovolemia should be considered and managed with appropriate parenteral fluid therapy. Repositioning the patient to improve venous return to the heart should be considered when operative conditions permit. It should be noted that in spinal and peridural anesthesia, tilting the patient into a head-down position may result in a higher level of anesthesia than is desirable, as well as impair venous return to the heart. Care should be exercised in moving and positioning of patients because of a possibility of orthostatic hypotension. If volume expansion with fluids plus these other countermeasures do not correct the hypotension, then the administration of pressor agents other than epinephrine should be considered. Epinephrine may paradoxically decrease the blood pressure in patients treated with droperidol due to the alpha-adrenergic blocking action of droperidol. Since droperidol may decrease pulmonary arterial pressure, this fact should be considered by those who conduct diagnostic or surgical procedures where interpretation of pulmonary arterial pressure measurements might determine final management of the patient. Vital signs and ECG should be monitored routinely. When the EEG is used for postoperative monitoring, it may be found that the EEG pattern returns to normal slowly. Impaired Hepatic or Renal Function: Droperidol should be administered with caution to patients with liver and kidney dysfunction because of the importance of these organs in the metabolism and excretion of drugs. Pheochromocytoma: In patients with diagnosed/suspected pheochromocytoma, severe hypertension and tachycardia have been observed after the administration of droperidol. Drug Interactions Potentially Arrhythmogenic Agents: Any drug known to have the potential to prolong the QT interval should not be used together with droperidol. Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. Caution should be used when patients are taking concomitant drugs known to induce hypokalemia or hypomagnesemia as they may precipitate QT prolongation and interact with droperidol. These would include diuretics, laxatives and supraphysiological use of steroid hormones with mineralocorticoid potential. CNS Depressant Drugs: Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with droperidol. When patients have received such drugs, the dose of droperidol required will be less than usual. Following the administration of droperidol, the dose of other CNS depressant drugs should be reduced. Carcinogenesis, Mutagenesis, Impairment of Fertility No carcinogenicity studies have been carried out with droperidol. The micronucleus test in female rats revealed no mutagenic effects in single oral doses as high as 160 mg/kg. An oral study in rats (Segment 1) revealed no impairment of fertility in either males or females at 0.63, 2.5 and 10 mg/kg doses (approximately 2, 9 and 36 times maximum recommended human iv/im dosage). Pregnancy Category C. Droperidol administered intravenously has been shown to cause a slight increase in mortality of the newborn rat at 4.4 times the upper human dose. At 44 times the upper human dose, mortality rate was comparable to that for control animals. Following intramuscular administration, increased mortality of the offspring at 1.8 times the upper human dose is attributed to CNS depression in the dams who neglected to remove placentae from their offspring. Droperidol has not been shown to be teratogenic in animals. There are no adequate and well-controlled studies in pregnant women. Droperidol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Labor and Delivery There are insufficient data to support the use of droperidol in labor and delivery. Therefore, such use is not recommended. Nursing Mothers It is not known whether droperidol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when droperidol is administered to a nursing mother. Pediatric Use The safety of droperidol in children younger than two years of age has not been established."],"how_supplied":["HOW SUPPLIED Droperidol Injection USP, (2.5 mg/mL) is available as: Product No. Strength Size How Packaged NDC 0517-9702-25 5 mg/2 mL 2 mL Single Dose Vial Boxes of 25 Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) (See USP Controlled Room Temperature). PROTECT FROM LIGHT. RETAIN IN CARTON UNTIL TIME OF USE."],"boxed_warning":["WARNING Cases of QT prolongation and/or torsade de pointes have been reported in patients receiving droperidol at doses at or below recommended doses. Some cases have occurred in patients with no known risk factors for QT prolongation and some cases have been fatal. Due to its potential for serious proarrhythmic effects and death, droperidol should be reserved for use in the treatment of patients who fail to show an acceptable response to other adequate treatments, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs (see CONTRAINDICATIONS , WARNINGS , PRECAUTIONS , and ADVERSE REACTIONS ). Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with droperidol. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, droperidol should NOT be administered. For patients in whom the potential benefit of droperidol treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2-3 hours after completing treatment to monitor for arrhythmias. Droperidol is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome. Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect."],"pediatric_use":["Pediatric Use The safety of droperidol in children younger than two years of age has not been established."],"effective_time":"20230320","nursing_mothers":["Nursing Mothers It is not known whether droperidol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when droperidol is administered to a nursing mother."],"adverse_reactions":["ADVERSE REACTIONS QT interval prolongation, torsade de pointes, cardiac arrest, and ventricular tachycardia have been reported in patients treated with droperidol. Some of these cases were associated with death. Some cases occurred in patients with no known risk factors, and some were associated with droperidol doses at or below recommended doses. Physicians should be alert to palpitations, syncope, or other symptoms suggestive of episodes of irregular cardiac rhythm in patients taking droperidol and promptly evaluate such cases (see WARNINGS, Effects on Cardiac Conduction ). The most common somatic adverse reactions reported to occur with droperidol are mild to moderate hypotension and tachycardia, but these effects usually subside without treatment. If hypotension occurs and is severe or persists, the possibility of hypovolemia should be considered and managed with appropriate parenteral fluid therapy. The most common behavioral adverse effects of droperidol include dysphoria, postoperative drowsiness, restlessness, hyperactivity and anxiety, which can either be the result of an inadequate dosage (lack of adequate treatment effect) or of an adverse drug reaction (part of the symptom complex of akathisia). Care should be taken to search for extrapyramidal signs and symptoms (dystonia, akathisia, oculogyric crisis) to differentiate these different clinical conditions. When extrapyramidal symptoms are the cause, they can usually be controlled with anticholinergic agents. Postoperative hallucinatory episodes (sometimes associated with transient periods of mental depression) have also been reported. Other less common reported adverse reactions include anaphylaxis, dizziness, chills and/or shivering, laryngospasm and bronchospasm. Elevated blood pressure, with or without pre-existing hypertension, has been reported following administration of droperidol combined with fentanyl citrate or other parenteral analgesics. This might be due to unexplained alterations in sympathetic activity following large doses; however, it is also frequently attributed to anesthetic or surgical stimulation during light anesthesia."],"contraindications":["CONTRAINDICATIONS Droperidol is contraindicated in patients with known or suspected QT prolongation (i.e., QTc interval greater than 440 msec for males or 450 msec for females). This would include patients with congenital long QT syndrome. Droperidol is contraindicated in patients with known hypersensitivity to the drug. Droperidol is not recommended for any use other than for the treatment of perioperative nausea and vomiting in patients for whom other treatments are ineffective or inappropriate (see WARNINGS )."],"drug_interactions":["Drug Interactions Potentially Arrhythmogenic Agents: Any drug known to have the potential to prolong the QT interval should not be used together with droperidol. Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants. Caution should be used when patients are taking concomitant drugs known to induce hypokalemia or hypomagnesemia as they may precipitate QT prolongation and interact with droperidol. These would include diuretics, laxatives and supraphysiological use of steroid hormones with mineralocorticoid potential. CNS Depressant Drugs: Other CNS depressant drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics) have additive or potentiating effects with droperidol. When patients have received such drugs, the dose of droperidol required will be less than usual. Following the administration of droperidol, the dose of other CNS depressant drugs should be reduced."],"how_supplied_table":["<table><col/><col/><col/><col/><tbody><tr><td valign=\"top\"> <content styleCode=\"bold\">Product No.</content></td><td valign=\"top\"> <content styleCode=\"bold\">Strength</content></td><td valign=\"top\"> <content styleCode=\"bold\">Size</content></td><td valign=\"top\"> <content styleCode=\"bold\">How Packaged</content></td></tr><tr><td valign=\"top\"> NDC 0517-9702-25</td><td valign=\"top\"> 5 mg/2 mL</td><td valign=\"top\"> 2 mL Single Dose Vial</td><td valign=\"top\"> Boxes of 25</td></tr></tbody></table>"],"labor_and_delivery":["Labor and Delivery There are insufficient data to support the use of droperidol in labor and delivery. Therefore, such use is not recommended."],"general_precautions":["General The initial dose of droperidol should be appropriately reduced in elderly, debilitated and other poor-risk patients. The effect of the initial dose should be considered in determining incremental doses. Certain forms of conduction anesthesia, such as spinal anesthesia and some peridural anesthetics, can alter respiration by blocking intercostal nerves and can cause peripheral vasodilation and hypotension because of sympathetic blockade. Through other mechanisms (see CLINICAL PHARMACOLOGY ), droperidol can also alter circulation. Therefore, when droperidol is used to supplement these forms of anesthesia, the anesthetist should be familiar with the physiological alterations involved, and be prepared to manage them in the patients elected for these forms of anesthesia. If hypotension occurs, the possibility of hypovolemia should be considered and managed with appropriate parenteral fluid therapy. Repositioning the patient to improve venous return to the heart should be considered when operative conditions permit. It should be noted that in spinal and peridural anesthesia, tilting the patient into a head-down position may result in a higher level of anesthesia than is desirable, as well as impair venous return to the heart. Care should be exercised in moving and positioning of patients because of a possibility of orthostatic hypotension. If volume expansion with fluids plus these other countermeasures do not correct the hypotension, then the administration of pressor agents other than epinephrine should be considered. Epinephrine may paradoxically decrease the blood pressure in patients treated with droperidol due to the alpha-adrenergic blocking action of droperidol. Since droperidol may decrease pulmonary arterial pressure, this fact should be considered by those who conduct diagnostic or surgical procedures where interpretation of pulmonary arterial pressure measurements might determine final management of the patient. Vital signs and ECG should be monitored routinely. When the EEG is used for postoperative monitoring, it may be found that the EEG pattern returns to normal slowly."],"clinical_pharmacology":["CLINICAL PHARMACOLOGY Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias but it does not prevent other cardiac arrhythmias. The onset of action of single intramuscular and intravenous doses is from three to ten minutes following administration, although the peak effect may not be apparent for up to thirty minutes. The duration of the tranquilizing and sedative effects generally is two to four hours, although alteration of alertness may persist for as long as twelve hours."],"indications_and_usage":["INDICATIONS AND USAGE Droperidol Injection is indicated to reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures."],"spl_unclassified_section":["For IV or IM Use Only Rx Only"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Dosage should be individualized . Some of the factors to be considered in determining the dose are age, body weight, physical status, underlying pathological condition, use of other drugs, type of anesthesia to be used, and the surgical procedure involved. Vital signs and ECG should be monitored routinely. Adult Dosage: The maximum recommended initial dose of droperidol is 2.5 mg IM or slow IV. Additional 1.25 mg doses of droperidol may be administered to achieve the desired effect. However, additional doses should be administered with caution, and only if the potential benefit outweighs the potential risk. Children’s Dosage: For children two to 12 years of age, the maximum recommended initial dose is 0.1 mg/kg, taking into account the patient's age and other clinical factors. However, additional doses should be administered with caution, and only if the potential benefit outweighs the potential risk. See WARNINGS and PRECAUTIONS for use of droperidol with other CNS depressants, and in patients with altered response. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If such abnormalities are observed, the drug should not be administered."],"spl_product_data_elements":["Droperidol Droperidol DROPERIDOL DROPERIDOL LACTIC ACID SODIUM HYDROXIDE WATER"],"package_label_principal_display_panel":["PACKAGE LABEL.PRINICIPAL DISPLAY PANEL - Container NDC 0517- 9702 -01 Rx Only Droperidol Injection, USP 5 mg/2 mL (2.5 mg/mL) For Intravenous or Intramuscular Use 2 mL Single-Dose Vial Discard Unused Portion Droperidol Vial Label","PACKAGE LABEL.PRINCIPAL DISPLAY PANEL - Carton NDC 0517- 9702 -25 DROPERIDOL INJECTION, USP 5 mg/2 mL (2.5 mg/mL) For Intravenous or Intramuscular Use 25 X 2 mL Single-Dose Vials Discard Unused Portion AMERICAN REGENT, INC. SHIRLEY, NY 11967 Droperidol Box Label","Serialization Label Serialization Label"],"carcinogenesis_and_mutagenesis_and_impairment_of_fertility":["Carcinogenesis, Mutagenesis, Impairment of Fertility No carcinogenicity studies have been carried out with droperidol. The micronucleus test in female rats revealed no mutagenic effects in single oral doses as high as 160 mg/kg. An oral study in rats (Segment 1) revealed no impairment of fertility in either males or females at 0.63, 2.5 and 10 mg/kg doses (approximately 2, 9 and 36 times maximum recommended human iv/im dosage)."]},"tags":[{"label":"Dopamine-2 Receptor Antagonist","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(2) dopamine receptor","category":"target"},{"label":"DRD2","category":"gene"},{"label":"ADRA1D","category":"gene"},{"label":"HTR2A","category":"gene"},{"label":"N05AD08","category":"atc"},{"label":"Intramuscular","category":"route"},{"label":"Injection","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Intra-Operative Nausea and Vomiting","category":"indication"},{"label":"Post-Operative Nausea and Vomiting","category":"indication"},{"label":"Rising","category":"company"},{"label":"Approved 1970s","category":"decade"},{"label":"Adjuvants, Anesthesia","category":"pharmacology"},{"label":"Antiemetics","category":"pharmacology"},{"label":"Antipsychotic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Dopamine Agents","category":"pharmacology"},{"label":"Dopamine Antagonists","category":"pharmacology"},{"label":"Dopamine D2 Receptor Antagonists","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":["WARNING Cases of QT prolongation and/or torsade de pointes have been reported in patients receiving droperidol at doses at or below recommended doses. Some cases have occurred in patients with no known risk factors for QT prolongation and some cases have been fatal. Due to its potential for serious proarrhythmic effects and death, droperidol should be reserved for use in the treatment of patients who fail to show an acceptable response to other adequate treatments, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs (see CONTRAINDICATIONS , WARNINGS , PRECAUTIONS , and ADVERSE REACTIONS ). Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with droperidol. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, droperidol should NOT be administered. For patients in whom the potential benefit of droperidol treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2-3 hours after completing treatment to monitor for arrhythmias. Droperidol is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome. Droperidol should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect."],"safetySignals":[{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"98 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"92 reports"},{"date":"","signal":"ANAPHYLACTIC SHOCK","source":"FDA FAERS","actionTaken":"89 reports"},{"date":"","signal":"DRUG INTERACTION","source":"FDA FAERS","actionTaken":"89 reports"},{"date":"","signal":"HYPOTENSION","source":"FDA FAERS","actionTaken":"78 reports"},{"date":"","signal":"RESTLESSNESS","source":"FDA FAERS","actionTaken":"72 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"70 reports"},{"date":"","signal":"CARDIAC ARREST","source":"FDA FAERS","actionTaken":"60 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"58 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"56 reports"}],"drugInteractions":[{"url":"/drug/high-risk-qt-prolonging-agents","drug":"High Risk QT Prolonging Agents","action":"Avoid combination","effect":"Moderate Risk QTc-Prolonging Agents may enhance the QTc-prolonging effect of Highest Risk QTc-Prolonging Agents","source":"DrugCentral","drugSlug":"high-risk-qt-prolonging-agents"},{"url":"/drug/cabergoline","drug":"cabergoline","action":"Monitor closely","effect":"May interact with Cabergoline","source":"DrugCentral","drugSlug":"cabergoline"},{"url":"/drug/entacapone","drug":"entacapone","action":"Monitor closely","effect":"May interact with Entacapone","source":"DrugCentral","drugSlug":"entacapone"},{"url":"/drug/levodopa","drug":"levodopa","action":"Monitor closely","effect":"May interact with Levodopa","source":"DrugCentral","drugSlug":"levodopa"},{"url":"/drug/pergolide","drug":"pergolide","action":"Monitor closely","effect":"May interact with Pergolide","source":"DrugCentral","drugSlug":"pergolide"},{"url":"/drug/pramipexole","drug":"pramipexole","action":"Monitor closely","effect":"May interact with Pramipexole","source":"DrugCentral","drugSlug":"pramipexole"},{"url":"/drug/ropinirole","drug":"ropinirole","action":"Monitor closely","effect":"May interact with Ropinirole Hydrochloride","source":"DrugCentral","drugSlug":"ropinirole"},{"url":"/drug/ziprasidone","drug":"ziprasidone","action":"Avoid combination","effect":"May interact with Ziprasidone","source":"DrugCentral","drugSlug":"ziprasidone"}],"commonSideEffects":[{"effect":"Hypotension","drugRate":"reported","severity":"unknown"},{"effect":"Tachycardia","drugRate":"reported","severity":"unknown"},{"effect":"Dysphoria","drugRate":"reported","severity":"unknown"},{"effect":"Postoperative drowsiness","drugRate":"reported","severity":"unknown"},{"effect":"Restlessness","drugRate":"reported","severity":"unknown"},{"effect":"Hyperactivity","drugRate":"reported","severity":"unknown"},{"effect":"Anxiety","drugRate":"reported","severity":"unknown"},{"effect":"Dystonia","drugRate":"reported","severity":"unknown"},{"effect":"Akathisia","drugRate":"reported","severity":"unknown"},{"effect":"Oculogyric crisis","drugRate":"reported","severity":"unknown"},{"effect":"Anaphylaxis","drugRate":"reported","severity":"unknown"},{"effect":"Dizziness","drugRate":"reported","severity":"unknown"},{"effect":"Chills and/or shivering","drugRate":"reported","severity":"unknown"},{"effect":"Laryngospasm","drugRate":"reported","severity":"unknown"},{"effect":"Bronchospasm","drugRate":"reported","severity":"unknown"},{"effect":"Elevated blood pressure","drugRate":"reported","severity":"unknown"},{"effect":"Hallucinatory episodes","drugRate":"reported","severity":"unknown"},{"effect":"Mental depression","drugRate":"reported","severity":"unknown"}],"contraindications":["Acute exacerbation of asthma","Alcoholism","Benign intracranial hypertension","Benign prostatic hyperplasia","Bradycardia","Cardiomegaly","Central nervous system depression","Chronic disease of respiratory system","Chronic heart failure","Chronic obstructive lung disease","Congenital long QT syndrome","Cor pulmonale","Decreased cardiac function","Decreased respiratory function","Dehydration","Depressive disorder","Disease of liver","Disorder of biliary tract","Drug AND/OR toxin-induced diarrhea","Extrapyramidal disease","Hypertensive disorder","Hypokalemia","Hypomagnesemia","Hypovolemia","Inflammatory bowel disease"],"specialPopulations":{"Pregnancy":"Droperidol administered intravenously has been shown to cause slight increase in mortality of the newborn rat at 4.4 times the upper human dose. At 44 times the upper human dose, mortality rate was comparable to that for control animals. Following intramuscular administration, increased mortality of the offspring at 1.8 times the upper human dose is attributed to CNS depression in the dams who neglected to remove placentae from their offspring. Droperidol has not been shown to be tera","Paediatric use":"The safety of droperidol in children younger than two years of age has not been established."}},"trials":[],"aliases":[],"company":"Rising","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DROPERIDOL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:19:01.970060+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:19:08.448523+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T03:19:00.592872+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DROPERIDOL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:19:09.183644+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:18:59.524725+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:18:59.524778+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (boxed_warning)","rawText":"WARNING Cases of QT prolongation and/or torsade de pointes have been reported in patients receiving droperidol at doses at or below recommended doses. Some cases have occurred in patients with no known risk factors for QT prolongation and some cases have been fatal. Due to its potential for serious proarrhythmic effects and death, droperidol should be reserved for use in the treatment of patients who fail to show an acceptable response to other adequate treatments, either because of insufficient","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:18:59.524794+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T03:19:12.032747+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: D2-like dopamine receptor antagonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:19:11.062669+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1108/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:19:10.961924+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"ANDA072123","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:18:59.524800+00:00"}},"allNames":"inapsine","offLabel":[],"synonyms":["droperidol","dehydrobenzperidol","droleptan","inapsin","inapsine","neurolidol"],"timeline":[{"date":"1970-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from AKORN INC to Rising"},{"date":"1970-06-11","type":"positive","source":"DrugCentral","milestone":"FDA approval (Akorn Inc)"},{"date":"1988-04-07","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 2 manufacturers approved"}],"aiSummary":"Inapsine (Droperidol) is a dopamine-2 receptor antagonist, a small molecule drug class, originally developed by AKORN INC and currently owned by Rising. It targets the D(2) dopamine receptor to treat Intra-Operative Nausea and Vomiting and Post-Operative Nausea and Vomiting. Inapsine is off-patent with 10 generic manufacturers, and its half-life is approximately 1.9 hours with 75% bioavailability. The drug has been FDA-approved since 1970. Key safety considerations include its potential for QT interval prolongation.","approvals":[{"date":"1970-06-11","orphan":false,"company":"AKORN INC","regulator":"FDA"}],"brandName":"Inapsine","ecosystem":[{"indication":"Intra-Operative Nausea and Vomiting","otherDrugs":[],"globalPrevalence":null},{"indication":"Post-Operative Nausea and Vomiting","otherDrugs":[{"name":"dolasetron","slug":"dolasetron","company":"Sanofi Aventis Us"},{"name":"granisetron","slug":"granisetron","company":"Roche"}],"globalPrevalence":null}],"mechanism":{"target":"D(2) dopamine receptor","novelty":"Follow-on","targets":[{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"},{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"}],"moaClass":"Dopamine D2 Antagonists","modality":"Small Molecule","drugClass":"Dopamine-2 Receptor Antagonist [EPC]","explanation":"","oneSentence":"","technicalDetail":"Inapsine acts as a competitive antagonist at the D(2) dopamine receptor, inhibiting the binding of dopamine and subsequent activation of G-protein coupled signaling pathways that contribute to nausea and vomiting."},"commercial":{"launchDate":"1970","_launchSource":"DrugCentral (FDA 1970-06-11, AKORN INC)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/966","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DROPERIDOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DROPERIDOL","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T10:53:43.395779","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:19:16.167456+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"haloperidol","drugSlug":"haloperidol","fdaApproval":"1967-04-12","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lumateperone","drugSlug":"lumateperone","fdaApproval":"2019-12-20","patentExpiry":"Oct 27, 2039","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"droperidol","indications":{"approved":[{"name":"Intra-Operative Nausea and Vomiting","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"},{"name":"Post-Operative Nausea and Vomiting","source":"DrugCentral","snomedId":1488000,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"}],"offLabel":[],"pipeline":[]},"currentOwner":"Rising","drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"haloperidol","brandName":"haloperidol","genericName":"haloperidol","approvalYear":"1967","relationship":"same-class"},{"drugId":"lumateperone","brandName":"lumateperone","genericName":"lumateperone","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07480785","phase":"NA","title":"TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients","status":"RECRUITING","sponsor":"Zhejiang University","startDate":"2026-01-16","conditions":["Uterine Fibroids (Leiomyoma)","Ovarian Tumors","Gallstones"],"enrollment":780,"completionDate":"2027-10-31"},{"nctId":"NCT01942343","phase":"PHASE3","title":"Akathisia in Post Operative Outpatients Surgery","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2013-10","conditions":["Akathisia"],"enrollment":300,"completionDate":"2015-10"},{"nctId":"NCT02858310","phase":"PHASE1,PHASE2","title":"E7 TCR T Cells for Human Papillomavirus-Associated Cancers","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-27","conditions":["Papillomavirus Infections","Cervical Intraepithelial Neoplasia","Carcinoma In Situ","Vulvar Neoplasms","Vulvar Diseases"],"enrollment":224,"completionDate":"2025-07-02"},{"nctId":"NCT01739985","phase":"NA","title":"Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-12","conditions":["Postoperative Vomiting"],"enrollment":322,"completionDate":"2014-05"},{"nctId":"NCT07015528","phase":"EARLY_PHASE1","title":"Assessment of Drug Liking In Peri-procedural Clinical Settings","status":"ENROLLING_BY_INVITATION","sponsor":"Stanford University","startDate":"2025-09-30","conditions":["Drug Liking"],"enrollment":100,"completionDate":"2027-07-31"},{"nctId":"NCT06982625","phase":"NA","title":"Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty","status":"RECRUITING","sponsor":"Institut Mutualiste Montsouris","startDate":"2025-09-22","conditions":["Hip Arthroplasty, Total","Post Operative Pain, Acute","Nerve Block"],"enrollment":310,"completionDate":"2027-12-31"},{"nctId":"NCT05065567","phase":"PHASE3","title":"Haloperidol, Droperidol, Ondansetron in Cannabis Hyperemesis","status":"TERMINATED","sponsor":"Corewell Health South","startDate":"2021-08-30","conditions":["Cyclic Vomiting Syndrome"],"enrollment":32,"completionDate":"2023-11-20"},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":["Elective Surgical Procedures","Postoperative Pain","Anesthesia","Opioid Use","Abdominal Aortic Aneurysm Without Rupture","Vascular Surgical Procedure","Interleukin 6","Immunomodulators"],"enrollment":40,"completionDate":"2027-10-08"},{"nctId":"NCT06726811","phase":"","title":"Droperidol and QTc Interval Changes in ED Patients","status":"RECRUITING","sponsor":"CHRISTUS Health","startDate":"2024-10-17","conditions":["Emergency Department Patient","QTc Intervals Changes"],"enrollment":500,"completionDate":"2026-09-30"},{"nctId":"NCT02078336","phase":"PHASE4","title":"Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2013-12","conditions":["Dental Care for Disabled"],"enrollment":40,"completionDate":"2025-07"},{"nctId":"NCT01298193","phase":"PHASE4","title":"Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer.","status":"COMPLETED","sponsor":"Spanish Breast Cancer Research Group","startDate":"2011-05","conditions":["Breast Cancer"],"enrollment":212,"completionDate":"2014-04"},{"nctId":"NCT05401058","phase":"NA","title":"Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2022-11-21","conditions":["Digestive System Disease","Urologic Diseases","Gynecological Disease","Orthopedic Surgery"],"enrollment":2968,"completionDate":"2024-12-31"},{"nctId":"NCT05244460","phase":"PHASE3","title":"Droperidol on Prevention of Cannabis Hyperemesis Syndrome","status":"UNKNOWN","sponsor":"Mercy Health Ohio","startDate":"2021-12-02","conditions":["Cannabis Hyperemesis Syndrome"],"enrollment":45,"completionDate":"2023-01-31"},{"nctId":"NCT03944681","phase":"NA","title":"Gender Influence on Torsadogenic Actions of Droperidol.","status":"COMPLETED","sponsor":"Medical University of Gdansk","startDate":"2019-04-23","conditions":["Arrhythmia, Droperidol"],"enrollment":50,"completionDate":"2020-12-31"},{"nctId":"NCT03825198","phase":"PHASE3","title":"Lumbar Erector Spinae Plane Block for Back Surgery","status":"UNKNOWN","sponsor":"Dr M. B. Breebaart","startDate":"2019-08-01","conditions":["Pain, Postoperative","Anaesthesia","Surgery","Nerve Block","Anesthesia, Local","Back Pain","Spinal Fusion"],"enrollment":80,"completionDate":"2023-12-15"},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":["Systemic Inflammatory Response Syndrome","Postoperative Pain, Acute","Postoperative Pain, Chronic","Infections Postoperative","Opioid Use","Anesthesia","Non-small Cell Lung Cancer"],"enrollment":70,"completionDate":"2026-11-01"},{"nctId":"NCT03023462","phase":"NA","title":"Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair","status":"COMPLETED","sponsor":"Ostfold Hospital Trust","startDate":"2019-09-05","conditions":["Inguinal Hernia","Pain, Postoperative"],"enrollment":60,"completionDate":"2020-06-30"},{"nctId":"NCT05068180","phase":"PHASE4","title":"Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2021-10-05","conditions":["Stomach Neoplasms","Colonic Neoplasms","Rectal Neoplasms","Sigmoid Neoplasms","Liver Neoplasms","Kidney Neoplasms","Urinary Bladder Neoplasms","Prostatic Neoplasms","Osteoarthropathy","Fractures, Bone","Gynecologic Cancer"],"enrollment":200,"completionDate":"2022-04-10"},{"nctId":"NCT04411069","phase":"PHASE2","title":"Simplified Algorithm for the Prevention of Postoperative Nausea and Vomiting in an Oncological Hospital","status":"COMPLETED","sponsor":"Instituto do Cancer do Estado de São Paulo","startDate":"2019-02-20","conditions":["Postoperative Nausea","Postoperative Vomiting"],"enrollment":270,"completionDate":"2021-03-20"},{"nctId":"NCT03546088","phase":"NA","title":"Awake Nasal Intubation in Laryngopharyngeal Tumors","status":"COMPLETED","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2018-02-20","conditions":["Airway Management"],"enrollment":32,"completionDate":"2018-12-25"},{"nctId":"NCT03036514","phase":"NA","title":"Sublingual Sufentanil Tablet System (SSTS) Versus Intravenous Patient Controlled Analgesia After Back Surgery.","status":"COMPLETED","sponsor":"University Hospital, Antwerp","startDate":"2017-04-05","conditions":["Pain, Postoperative"],"enrollment":27,"completionDate":"2019-09-01"},{"nctId":"NCT03677323","phase":"NA","title":"Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.","status":"COMPLETED","sponsor":"Clinique Saint Jean, France","startDate":"2019-01-02","conditions":["Hallux Valgus","Surgery"],"enrollment":60,"completionDate":"2019-02-21"},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":["Postoperative Nausea and Vomiting"],"enrollment":27034,"completionDate":"2017-11-30"},{"nctId":"NCT03828981","phase":"NA","title":"A Fast-track Versus Conventional Recovery Protocol in Laparoscopic Hysterctomy","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2016-05-31","conditions":["Gynecologic Surgery"],"enrollment":120,"completionDate":"2018-05-30"},{"nctId":"NCT02600741","phase":"","title":"Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)","status":"COMPLETED","sponsor":"Janssen Scientific Affairs, LLC","startDate":"2015-07-24","conditions":["Schizophrenia"],"enrollment":296,"completionDate":"2018-07-05"},{"nctId":"NCT01594749","phase":"PHASE3","title":"Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2012-09-24","conditions":["Chemotherapy-Induced Nausea and Vomiting (CINV)"],"enrollment":1015,"completionDate":"2014-11-03"},{"nctId":"NCT01406860","phase":"NA","title":"Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches","status":"TERMINATED","sponsor":"University of Iowa","startDate":"2011-07","conditions":["Primary Headaches (Includes Migraines, Tension, Cluster Headaches)"],"enrollment":19,"completionDate":"2012-07"},{"nctId":"NCT00624208","phase":"NA","title":"The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2008-02","conditions":["Myocardial Repolarization"],"enrollment":80,"completionDate":"2009-08"},{"nctId":"NCT03277391","phase":"NA","title":"Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery","status":"UNKNOWN","sponsor":"Université Libre de Bruxelles","startDate":"2017-04-14","conditions":["Regional Anesthesia","Thoracic Surgery","Post-operative Pain","Post-operative Chronic Pain","Pharmacokinetic Analysis","Serratus Anterior Plane Block"],"enrollment":20,"completionDate":"2018-05"},{"nctId":"NCT02744495","phase":"PHASE3","title":"Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery","status":"COMPLETED","sponsor":"Hôpital Privé de Parly II - Le Chesnay","startDate":"2016-02","conditions":["Postoperative Vomiting","Postoperative Nausea","Postoperative Emesis"],"enrollment":502,"completionDate":"2016-12"},{"nctId":"NCT01679093","phase":"PHASE3","title":"Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia.","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2009-06","conditions":["Interaction Between Antiemetic Drugs and Paracetamol"],"enrollment":66,"completionDate":"2011-06"},{"nctId":"NCT02282956","phase":"PHASE4","title":"Ultrasound Guided Single Shot Block of Posterior Tibial Nerve for Postoperative Pain Relief After Hallux Valgus Surgery","status":"UNKNOWN","sponsor":"Dr.med. 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