{"id":"doxycycline-and-tauroursodeoxycholic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (nausea, diarrhea)"},{"rate":null,"effect":"Photosensitivity (doxycycline-related)"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":{"chemblId":"CHEMBL2447928","moleculeType":"Small molecule","molecularWeight":"746.90"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Doxycycline is a tetracycline antibiotic with anti-inflammatory and anti-fibrotic properties that inhibit matrix metalloproteinases and reduce inflammatory cytokine production. Tauroursodeoxycholic acid (TUDCA) is a bile acid that activates farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (TGR5), enhancing mitochondrial function and reducing endoplasmic reticulum stress. Together, they target multiple pathways involved in liver disease progression.","oneSentence":"Doxycycline and tauroursodeoxycholic acid combination works by reducing inflammation and oxidative stress while promoting bile acid signaling to protect mitochondrial function and reduce hepatocellular injury.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:54.512Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Primary biliary cholangitis (PBC)"},{"name":"Non-alcoholic fatty liver disease (NAFLD) / Non-alcoholic steatohepatitis (NASH)"}]},"trialDetails":[{"nctId":"NCT03431896","phase":"","title":"Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2018-02-01","conditions":"Amyloidosis, Amyloid, Amyloid Neuropathies, Familial","enrollment":37},{"nctId":"NCT03481972","phase":"PHASE3","title":"A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin","status":"COMPLETED","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2018-04-11","conditions":"TTR Cardiac Amyloidosis","enrollment":102},{"nctId":"NCT01855360","phase":"PHASE1, PHASE2","title":"Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2013-06","conditions":"Amyloidosis; Heart (Manifestation), Senile Cardiac Amyloidosis","enrollment":40},{"nctId":"NCT01171859","phase":"PHASE2","title":"Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin Amyloidosis","status":"COMPLETED","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2010-07","conditions":"Transthyretin Amyloidosis","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Standard of care therpay"],"phase":"phase_3","status":"active","brandName":"Doxycycline and tauroursodeoxycholic acid","genericName":"Doxycycline and tauroursodeoxycholic acid","companyName":"Fondazione IRCCS Policlinico San Matteo di Pavia","companyId":"fondazione-irccs-policlinico-san-matteo-di-pavia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Doxycycline and tauroursodeoxycholic acid combination works by reducing inflammation and oxidative stress while promoting bile acid signaling to protect mitochondrial function and reduce hepatocellular injury. Used for Primary biliary cholangitis (PBC), Non-alcoholic fatty liver disease (NAFLD) / Non-alcoholic steatohepatitis (NASH).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}