{"id":"doxefazepam","rwe":[{"pmid":"38417328","year":"2024","title":"Proteomic-metabolomic combination analysis reveals novel biomarkers of meat quality that differ between young and older ducks.","finding":"","journal":"Poultry science","studyType":"Clinical Study"},{"pmid":"9097119","year":"1996","title":"Doxefazepam.","finding":"","journal":"IARC monographs on the evaluation of carcinogenic risks to humans","studyType":"Clinical Study"},{"pmid":"1973676","year":"1990","title":"Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats.","finding":"","journal":"Fundamental and applied toxicology : official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"2568837","year":"1989","title":"Toxicological evaluations of the benzodiazepine doxefazepam.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"6483162","year":"1984","title":"Effects of doxefazepam on normal sleep. An EEG and neuropsychological study.","finding":"","journal":"Neuropsychobiology","studyType":"Clinical Study"}],"tags":[{"label":"doxefazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05CD12","category":"atc"},{"label":"Active","category":"status"},{"label":"Insomnia","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"doxans","offLabel":[],"synonyms":["doxefazepam","doxans"],"timeline":[],"approvals":[],"brandName":"Doxans","ecosystem":[{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000}],"mechanism":{"modality":"Small Molecule","drugClass":"doxefazepam","explanation":"Imagine your brain is like a busy city with lots of noise and activity. GABA is like a traffic cop that helps to slow down the traffic and calm things down. Doxefazepam helps GABA do its job more effectively, making it easier to fall asleep and stay asleep.","oneSentence":"Doxefazepam works by enhancing the activity of a neurotransmitter called GABA, which helps to calm the brain and induce sleep.","technicalDetail":"Doxefazepam acts as a benzodiazepine receptor agonist, specifically binding to the GABA_A receptor and enhancing the activity of GABA, a major inhibitory neurotransmitter in the brain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/955","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DOXEFAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:50:21.660076","biosimilars":[],"competitors":[{"drugName":"flurazepam","drugSlug":"flurazepam","fdaApproval":"1970-04-07","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"estazolam","drugSlug":"estazolam","fdaApproval":"1990-12-26","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"triazolam","drugSlug":"triazolam","fdaApproval":"1982-11-15","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"temazepam","drugSlug":"temazepam","fdaApproval":"1981-02-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"midazolam","drugSlug":"midazolam","fdaApproval":"1985-12-20","patentExpiry":"Jun 20, 2038","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"quazepam","drugSlug":"quazepam","fdaApproval":"1985-12-27","patentExpiry":"Jun 3, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"remimazolam","drugSlug":"remimazolam","fdaApproval":"2020-07-02","patentExpiry":"Nov 7, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"doxefazepam","indications":{"approved":[{"name":"Insomnia","source":"DrugCentral","snomedId":193462001,"regulator":"FDA","usPrevalence":70000000,"globalPrevalence":750000000,"prevalenceMethod":"curated","prevalenceSource":"Sleep Medicine Reviews, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"flurazepam","brandName":"flurazepam","genericName":"flurazepam","approvalYear":"1970","relationship":"same-class"},{"drugId":"estazolam","brandName":"estazolam","genericName":"estazolam","approvalYear":"1990","relationship":"same-class"},{"drugId":"triazolam","brandName":"triazolam","genericName":"triazolam","approvalYear":"1982","relationship":"same-class"},{"drugId":"temazepam","brandName":"temazepam","genericName":"temazepam","approvalYear":"1981","relationship":"same-class"},{"drugId":"midazolam","brandName":"midazolam","genericName":"midazolam","approvalYear":"1985","relationship":"same-class"},{"drugId":"quazepam","brandName":"quazepam","genericName":"quazepam","approvalYear":"1985","relationship":"same-class"},{"drugId":"remimazolam","brandName":"remimazolam","genericName":"remimazolam","approvalYear":"2020","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"231RV72C8L","CHEBI":"CHEBI:82460","INN_ID":"4766","UMLSCUI":"C0114875","ChEMBL_ID":"CHEMBL64677","KEGG_DRUG":"D07327","DRUGBANK_ID":"DB13837","PUBCHEM_CID":"38668","MESH_SUPPLEMENTAL_RECORD_UI":"C008020"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05CD12","allCodes":["N05CD12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Apr","pmid":"38417328","title":"Proteomic-metabolomic combination analysis reveals novel biomarkers of meat quality that differ between young and older ducks.","journal":"Poultry science"},{"date":"1996","pmid":"9097119","title":"Doxefazepam.","journal":"IARC monographs on the evaluation of carcinogenic risks to humans"},{"date":"1990 Jul","pmid":"1973676","title":"Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats.","journal":"Fundamental and applied toxicology : official journal of the Society of Toxicology"},{"date":"1989 Apr","pmid":"2568837","title":"Toxicological evaluations of the benzodiazepine doxefazepam.","journal":"Arzneimittel-Forschung"},{"date":"1984","pmid":"6483162","title":"Effects of doxefazepam on normal sleep. An EEG and neuropsychological study.","journal":"Neuropsychobiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Doxefazepam, also known as DOXEFAZEPAM, is a small molecule belonging to the drug class of doxefazepam. It is used to treat insomnia, but its target is currently unknown. The commercial status of doxefazepam is unclear, and it is not known if it is patented or available as a generic medication. Further information on its pharmacokinetics, such as half-life and bioavailability, is also unavailable. Doxefazepam's approval status and indications are limited to insomnia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}