{"id":"dovonex-calcipotriol","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation at application site"},{"rate":null,"effect":"Burning or stinging sensation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Hypercalcemia (with systemic absorption)"}]},"_chembl":{"chemblId":"CHEMBL4563773","moleculeType":"Unknown","molecularWeight":"412.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriol acts as a selective vitamin D receptor agonist, promoting normal differentiation of keratinocytes and inhibiting their proliferation. This mechanism helps normalize the abnormal skin cell turnover characteristic of psoriasis and other hyperproliferative skin disorders. By modulating immune responses and reducing inflammatory cytokine production in the skin, it addresses both the cellular and immunological components of psoriatic plaques.","oneSentence":"Calcipotriol is a vitamin D3 analog that binds to the vitamin D receptor to regulate skin cell proliferation and differentiation, reducing excessive keratinocyte growth.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:51.204Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis"},{"name":"Psoriatic dermatitis"}]},"trialDetails":[{"nctId":"NCT07401992","phase":"PHASE4","title":"Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis","status":"RECRUITING","sponsor":"Hospital Universitario Dr. Jose E. 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