{"id":"double-antiplatelet-therapy","safety":{"commonSideEffects":[{"rate":"2-5","effect":"Bleeding"},{"rate":"1-3","effect":"Gastrointestinal bleeding"},{"rate":"5-10","effect":"Dyspepsia"},{"rate":null,"effect":"Bruising"},{"rate":"0.5-1","effect":"Intracranial hemorrhage"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a therapeutic regimen rather than a single drug, typically combining aspirin (which inhibits cyclooxygenase and thromboxane A2 production) with a P2Y12 receptor antagonist (such as clopidogrel, prasugrel, or ticagrelor) to provide dual inhibition of platelet activation and aggregation. The combination provides superior antithrombotic efficacy compared to monotherapy, particularly in acute coronary syndromes and after percutaneous coronary intervention.","oneSentence":"Double antiplatelet therapy combines two antiplatelet agents to inhibit platelet aggregation through different mechanisms, reducing thrombotic events.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:58.731Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome"},{"name":"Percutaneous coronary intervention with stent placement"},{"name":"Secondary prevention of myocardial infarction"},{"name":"Stroke prevention in high-risk patients"}]},"trialDetails":[{"nctId":"NCT05754957","phase":"PHASE3","title":"A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2023-04-07","conditions":"Acute Coronary 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