{"id":"dotarem-enhanced-mri","safety":{"commonSideEffects":[{"rate":"2-3%","effect":"Headache"},{"rate":"1-2%","effect":"Nausea"},{"rate":"1-2%","effect":"Injection site reactions"},{"rate":"1%","effect":"Dizziness"},{"rate":null,"effect":"Gadolinium deposition in tissues"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dotarem contains gadolinium, a paramagnetic metal ion that shortens the T1 relaxation time of water protons in tissues, causing increased signal intensity on T1-weighted MRI images. This allows better visualization and differentiation of anatomical structures and pathological lesions. The gadolinium is chelated (bound) to DTPA (diethylenetriaminepentaacetic acid) to improve safety and reduce toxicity.","oneSentence":"Dotarem is a gadolinium-based contrast agent that enhances MRI signal by altering the magnetic properties of nearby water molecules in tissues.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:33.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"MRI enhancement of the brain, spine, and associated tissues"},{"name":"MRI enhancement of the body (chest, abdomen, pelvis)"},{"name":"MRI angiography"}]},"trialDetails":[{"nctId":"NCT06267807","phase":"NA","title":"Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2024-03-27","conditions":"Lymphatic System Disorders Congenital, Lymphatic Diseases, Noonan Syndrome","enrollment":9},{"nctId":"NCT03337594","phase":"","title":"Gadolinium Retention in Human Bone Tissue in Pediatric Patients","status":"COMPLETED","sponsor":"Donna Roberts","startDate":"2017-10-01","conditions":"Gadolinium, MultiHance, Dotarem","enrollment":57},{"nctId":"NCT04341129","phase":"EARLY_PHASE1","title":"Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2020-07-13","conditions":"Breast Neoplasms, Breast Diseases, Breast Fibroadenoma","enrollment":50},{"nctId":"NCT03057561","phase":"NA","title":"Efficacy of Dotarem® (Gd-DOTA) Versus Gadovist® (Gd-DO3A-butrol) for Late Gadolinium Enhancement Cardiac Magnetic Resonance","status":"UNKNOWN","sponsor":"Dipan Shah","startDate":"2016-10-01","conditions":"Coronary Artery Disease, Cardiomyopathy","enrollment":120},{"nctId":"NCT02034708","phase":"PHASE4","title":"Efficacy Evaluation of Dotarem®-Enhanced MRI Compared to Gadovist®/Gadavist®-Enhanced MRI in the Diagnosis of Brain Tumors","status":"COMPLETED","sponsor":"Guerbet","startDate":"2014-06","conditions":"Primary Brain Tumor","enrollment":279},{"nctId":"NCT00650845","phase":"PHASE4","title":"Renal Safety Evaluation After Dotarem®-Enhanced MRI","status":"COMPLETED","sponsor":"Guerbet","startDate":"2008-01","conditions":"Renal Insufficiency","enrollment":135},{"nctId":"NCT00764387","phase":"PHASE4","title":"Contrast Enhanced MRI of the CNS - Patients With Known Cerebral Neoplastic Lesions.","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-03","conditions":"Neoplastic CNS Lesions","enrollment":166}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gadoterate meglumine","Gadoteric acid"],"phase":"marketed","status":"active","brandName":"Dotarem®-enhanced MRI","genericName":"Dotarem®-enhanced MRI","companyName":"Guerbet","companyId":"guerbet","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dotarem is a gadolinium-based contrast agent that enhances MRI signal by altering the magnetic properties of nearby water molecules in tissues. Used for MRI enhancement of the brain, spine, and associated tissues, MRI enhancement of the body (chest, abdomen, pelvis), MRI angiography.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}