{"id":"dosage-of-calcium-edetate-de-sodium","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity / acute kidney injury"},{"rate":null,"effect":"Hypocalcemia"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia / arthralgia"},{"rate":null,"effect":"Gastrointestinal disturbance"}]},"_chembl":{"chemblId":"CHEMBL2106963","moleculeType":"Small molecule","molecularWeight":"416.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium calcium edetate contains a chelating ligand (ethylenediaminetetraacetic acid) that forms tight coordination complexes with divalent and trivalent metal ions, most notably lead. The drug preferentially exchanges its calcium for toxic metals in the bloodstream and tissues, allowing the metal-chelate complexes to be renally eliminated while minimizing depletion of essential minerals.","oneSentence":"Sodium calcium edetate is a chelating agent that binds and removes heavy metals (particularly lead) from the body by forming stable complexes that are excreted in urine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:48.127Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lead poisoning (acute and chronic lead intoxication)"},{"name":"Heavy metal toxicity"}]},"trialDetails":[{"nctId":"NCT02300376","phase":"PHASE3","title":"Designing a Bayesian Model of the Plasma Clearance of Calcium Edetate de Sodium for the Calculation of GFR and Validity Compared to the Renal Clearance of Inulin","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2014-12","conditions":"Kidney Disease","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dosage of Calcium edetate de sodium","genericName":"Dosage of Calcium edetate de sodium","companyName":"University Hospital, Limoges","companyId":"university-hospital-limoges","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium calcium edetate is a chelating agent that binds and removes heavy metals (particularly lead) from the body by forming stable complexes that are excreted in urine. Used for Lead poisoning (acute and chronic lead intoxication), Heavy metal toxicity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}