{"id":"domiodol","rwe":[{"pmid":"1610421","year":"1992","title":"Mucolytic effects of domiodol in tracheostomized patients after total laryngectomy. Double-blind, placebo-controlled, randomized pilot study with four-month follow-up.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"3280363","year":"1988","title":"Domiodol treatment for bronchopulmonary diseases in the paediatric age group: a double-blind controlled clinical trial versus placebo.","finding":"","journal":"The Journal of international medical research","studyType":"Clinical Study"},{"pmid":"6500024","year":"1984","title":"Absorption, distribution, excretion and metabolism of domiodol.","finding":"","journal":"Il Farmaco; edizione pratica","studyType":"Clinical Study"},{"pmid":"6685509","year":"1983","title":"Pharmacological and toxicological studies on domiodol, a new mucolytic agent and expectorant.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"6685484","year":"1983","title":"Domiodol; separation of cis and trans isomers and comparison of their pharmacological activity.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"domiodol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05CB08","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mucolitico","offLabel":[],"synonyms":["domiodol","mucolitico"],"timeline":[],"approvals":[],"brandName":"Mucolitico","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"domiodol","explanation":"Imagine your body's mucus as a sticky, thick glue that can clog up your airways or digestive system. Mucolitico helps to break down this glue, making it easier to expel and relieving congestion and discomfort. This can be especially helpful for people with conditions like chronic bronchitis or cystic fibrosis.","oneSentence":"Mucolitico works by breaking down and dissolving mucus in the body.","technicalDetail":"Mucolitico exerts its effects by inhibiting the enzyme responsible for mucus production, leading to a decrease in mucus viscosity and an increase in its solubility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/944","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DOMIODOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:49:05.348911","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:07:33.250271+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"acetylcysteine","drugSlug":"acetylcysteine","fdaApproval":"1963-09-14","patentExpiry":"May 8, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"mesna","drugSlug":"mesna","fdaApproval":"1988-12-30","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dornase alfa","drugSlug":"dornase-alfa","fdaApproval":"1993-12-30","relationship":"same-class"},{"drugName":"mannitol","drugSlug":"mannitol","fdaApproval":"1964-06-08","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"domiodol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylcysteine","brandName":"acetylcysteine","genericName":"acetylcysteine","approvalYear":"1963","relationship":"same-class"},{"drugId":"mesna","brandName":"mesna","genericName":"mesna","approvalYear":"1988","relationship":"same-class"},{"drugId":"dornase-alfa","brandName":"dornase alfa","genericName":"dornase alfa","approvalYear":"1993","relationship":"same-class"},{"drugId":"mannitol","brandName":"mannitol","genericName":"mannitol","approvalYear":"1964","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"C1PXF8V06N","CHEBI":"CHEBI:134992","INN_ID":"4326","UMLSCUI":"C0048365","ChEMBL_ID":"CHEMBL2106471","KEGG_DRUG":"D03888","DRUGBANK_ID":"DB13768","PUBCHEM_CID":"43814","MESH_SUPPLEMENTAL_RECORD_UI":"C027858"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Respiratory"],"atcClassification":{"source":"DrugCentral","atcCode":"R05CB08","allCodes":["R05CB08"]},"biosimilarFilings":[],"recentPublications":[{"date":"1992 Feb","pmid":"1610421","title":"Mucolytic effects of domiodol in tracheostomized patients after total laryngectomy. Double-blind, placebo-controlled, randomized pilot study with four-month follow-up.","journal":"Arzneimittel-Forschung"},{"date":"1988 Jan-Feb","pmid":"3280363","title":"Domiodol treatment for bronchopulmonary diseases in the paediatric age group: a double-blind controlled clinical trial versus placebo.","journal":"The Journal of international medical research"},{"date":"1984 Sep","pmid":"6500024","title":"Absorption, distribution, excretion and metabolism of domiodol.","journal":"Il Farmaco; edizione pratica"},{"date":"1983","pmid":"6685509","title":"Pharmacological and toxicological studies on domiodol, a new mucolytic agent and expectorant.","journal":"Arzneimittel-Forschung"},{"date":"1983","pmid":"6685484","title":"Domiodol; separation of cis and trans isomers and comparison of their pharmacological activity.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mucolitico (DOMIODOL) is a small molecule drug in the domiodol class, developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. Mucolitico is used to treat unknown indications, and its commercial status, including patent status and generic availability, is unclear. Key safety considerations are also unknown. Further research is needed to fully understand this medication.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:07:33.250271+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}