{"id":"docusate-natrium-and-sorbitol","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Flatulence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Docusate sodium is an anionic surfactant that lowers the surface tension of the stool-water interface, allowing water to penetrate and soften the stool mass. Sorbitol is a sugar alcohol that is poorly absorbed in the small intestine, creating an osmotic gradient that draws water into the colon, increasing stool bulk and promoting bowel movement. Together, they provide both softening and osmotic laxative effects for constipation relief.","oneSentence":"Docusate sodium acts as a stool softener by reducing surface tension of feces, while sorbitol acts as an osmotic laxative to increase water retention in the bowel.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:44:54.860Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation"}]},"trialDetails":[{"nctId":"NCT01879605","phase":"PHASE4","title":"Study About Effect of Preoperative Bowel Preparation Versus no Bowel Preparation Before Spinal Surgery","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2007-12","conditions":"Constipation, Ileus, Surgery","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Klyx"],"phase":"marketed","status":"active","brandName":"Docusate natrium and sorbitol","genericName":"Docusate natrium and sorbitol","companyName":"Oslo University Hospital","companyId":"oslo-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Docusate sodium acts as a stool softener by reducing surface tension of feces, while sorbitol acts as an osmotic laxative to increase water retention in the bowel. Used for Constipation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}