{"id":"docosanoic-acid","rwe":[{"pmid":"41834967","year":"2026","title":"[The Relationship Between Serum Very Long-chain Saturated Fatty Acids and Chronic Kidney Disease].","finding":"","journal":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","studyType":"Clinical Study"},{"pmid":"41814159","year":"2026","title":"Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.","finding":"","journal":"Nucleic acid therapeutics","studyType":"Clinical Study"},{"pmid":"41697614","year":"2026","title":"Exploring the Role of E. Coli Nissle 1917 Postbiotics as Antimicrobial and Antioxidant Agents for Enhancing Buffalo Sperm Quality.","finding":"","journal":"Probiotics and antimicrobial proteins","studyType":"Clinical Study"},{"pmid":"41666174","year":"2026","title":"Integrated microbiomics and metabolomics analysis reveals distinct profiles in carbapenem-resistant Acinetobacter baumannii and Escherichia coli infections in Pancreatitis-associated sepsis.","finding":"","journal":"PloS one","studyType":"Clinical Study"},{"pmid":"41472703","year":"2025","title":"Fatty acid synthesis: A critical factor determining mycelial growth rate in Pleurotus tuoliensis.","finding":"","journal":"Food chemistry. Molecular sciences","studyType":"Clinical Study"}],"tags":[{"label":"docosanoic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Peroxisome proliferator-activated receptor alpha","category":"target"},{"label":"PPARA","category":"gene"},{"label":"PPARD","category":"gene"},{"label":"PPARG","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hydrofol","offLabel":[],"synonyms":["docosanoic acid","behenic acid","hydrofol"],"timeline":[],"approvals":[],"brandName":"Hydrofol","ecosystem":[],"mechanism":{"target":"Peroxisome proliferator-activated receptor delta, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor gamma","targets":[{"gene":"PPARA","source":"DrugCentral","target":"Peroxisome proliferator-activated receptor alpha","protein":"Peroxisome proliferator-activated receptor alpha"},{"gene":"PPARD","source":"DrugCentral","target":"Peroxisome proliferator-activated receptor delta","protein":"Peroxisome proliferator-activated receptor delta"},{"gene":"PPARG","source":"DrugCentral","target":"Peroxisome proliferator-activated receptor gamma","protein":"Peroxisome proliferator-activated receptor gamma"}],"modality":"Small Molecule","drugClass":"docosanoic acid","explanation":"Think of PPAR-alpha like a master switch that controls how your body uses fat. When Hydrofol activates this switch, it helps your body break down and use fat more efficiently, which can be beneficial for people with certain health conditions. This process also affects how your body produces energy and uses other nutrients.","oneSentence":"Hydrofol works by activating the peroxisome proliferator-activated receptor alpha (PPAR-alpha), a protein that regulates the expression of genes involved in lipid metabolism.","technicalDetail":"Hydrofol binds to the PPAR-alpha receptor, inducing a conformational change that allows it to interact with coactivator proteins and recruit RNA polymerase to the promoter region of target genes, leading to increased transcription of genes involved in lipid metabolism and energy homeostasis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3855","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=docosanoic acid","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:48:20.434159","biosimilars":[],"competitors":[{"drugName":"choline fenofibrate","drugSlug":"choline-fenofibrate","fdaApproval":"2008-12-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clofibrate","drugSlug":"clofibrate","fdaApproval":"1967-02-08","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dodecanoic acid","drugSlug":"dodecanoic-acid","fdaApproval":"","relationship":"same-target"},{"drugName":"eicosapentaenoic acid","drugSlug":"eicosapentaenoic-acid","fdaApproval":"","relationship":"same-target"},{"drugName":"fenofibrate","drugSlug":"fenofibrate","fdaApproval":"1993-12-31","patentExpiry":"May 31, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"gemfibrozil","drugSlug":"gemfibrozil","fdaApproval":"1981-12-21","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"linolenic acid","drugSlug":"linolenic-acid","fdaApproval":"","relationship":"same-target"},{"drugName":"oleic acid","drugSlug":"oleic-acid","fdaApproval":"","relationship":"same-target"},{"drugName":"pioglitazone","drugSlug":"pioglitazone","fdaApproval":"1999-07-15","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"rosiglitazone","drugSlug":"rosiglitazone","fdaApproval":"1999-05-25","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"docosanoic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"choline-fenofibrate","brandName":"choline fenofibrate","genericName":"choline fenofibrate","approvalYear":"2008","relationship":"same-target"},{"drugId":"clofibrate","brandName":"clofibrate","genericName":"clofibrate","approvalYear":"1967","relationship":"same-target"},{"drugId":"dodecanoic-acid","brandName":"dodecanoic acid","genericName":"dodecanoic acid","approvalYear":"","relationship":"same-target"},{"drugId":"eicosapentaenoic-acid","brandName":"eicosapentaenoic acid","genericName":"eicosapentaenoic acid","approvalYear":"","relationship":"same-target"},{"drugId":"fenofibrate","brandName":"fenofibrate","genericName":"fenofibrate","approvalYear":"1993","relationship":"same-target"},{"drugId":"gemfibrozil","brandName":"gemfibrozil","genericName":"gemfibrozil","approvalYear":"1981","relationship":"same-target"},{"drugId":"linolenic-acid","brandName":"linolenic acid","genericName":"linolenic acid","approvalYear":"","relationship":"same-target"},{"drugId":"oleic-acid","brandName":"oleic acid","genericName":"oleic acid","approvalYear":"","relationship":"same-target"},{"drugId":"pioglitazone","brandName":"pioglitazone","genericName":"pioglitazone","approvalYear":"1999","relationship":"same-target"},{"drugId":"rosiglitazone","brandName":"rosiglitazone","genericName":"rosiglitazone","approvalYear":"1999","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"013590","UNII":"H390488X0A","CHEBI":"CHEBI:28941","RXNORM":"1368203","UMLSCUI":"C0053073","ChEMBL_ID":"CHEMBL1173474","PDB_CHEM_ID":" EO3","PUBCHEM_CID":"8215","MESH_SUPPLEMENTAL_RECORD_UI":"C007547"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":150,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 20","pmid":"41834967","title":"[The Relationship Between Serum Very Long-chain Saturated Fatty Acids and Chronic Kidney Disease].","journal":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition"},{"date":"2026 Mar 11","pmid":"41814159","title":"Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.","journal":"Nucleic acid therapeutics"},{"date":"2026 Feb 16","pmid":"41697614","title":"Exploring the Role of E. Coli Nissle 1917 Postbiotics as Antimicrobial and Antioxidant Agents for Enhancing Buffalo Sperm Quality.","journal":"Probiotics and antimicrobial proteins"},{"date":"2026","pmid":"41666174","title":"Integrated microbiomics and metabolomics analysis reveals distinct profiles in carbapenem-resistant Acinetobacter baumannii and Escherichia coli infections in Pancreatitis-associated sepsis.","journal":"PloS one"},{"date":"2025 Dec","pmid":"41472703","title":"Fatty acid synthesis: A critical factor determining mycelial growth rate in Pleurotus tuoliensis.","journal":"Food chemistry. Molecular sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Hydrofol, also known as docosanoic acid, is a small molecule drug that targets the peroxisome proliferator-activated receptor alpha (PPAR-alpha). It is a member of the docosanoic acid class and its mechanism of action is not FDA approved. The exact indications for Hydrofol are unknown, and its commercial status, including patent status and generic availability, is also unclear. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are not well established. Further research is needed to fully understand the potential benefits and risks of Hydrofol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}