{"id":"docarpamine","rwe":[{"pmid":"23676366","year":"2013","title":"Efficacy and limitations of oral inotropic agents for the treatment of chronic heart failure.","finding":"","journal":"International heart journal","studyType":"Clinical Study"},{"pmid":"19743995","year":"2009","title":"Ascites and spontaneous bacterial peritonitis: an Asian perspective.","finding":"","journal":"Journal of gastroenterology and hepatology","studyType":"Clinical Study"},{"pmid":"16439609","year":"2006","title":"Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.","finding":"","journal":"Clinical chemistry","studyType":"Clinical Study"},{"pmid":"14503971","year":"2003","title":"Treatment for ovarian hyperstimulation syndrome using an oral dopamine prodrug, docarpamine.","finding":"","journal":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology","studyType":"Clinical Study"},{"pmid":"11996645","year":"2002","title":"The therapeutic potential of dopamine modulators on the cardiovascular and renal systems.","finding":"","journal":"Expert opinion on investigational drugs","studyType":"Clinical Study"}],"tags":[{"label":"Catecholamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Dopamine Agents","category":"pharmacology"},{"label":"Dopamine Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tanadopa","offLabel":[],"synonyms":["docarpamine","tanadopa"],"timeline":[],"approvals":[],"brandName":"Tanadopa","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Catecholamine","explanation":"Think of Tanadopa like a key that unlocks more of a certain chemical messenger in the brain called norepinephrine. This chemical helps us feel more alert and focused, and Tanadopa helps to turn up the volume on this signal. As a result, people taking Tanadopa may feel more awake and alert, but the exact effects can vary depending on the individual and the condition being treated.","oneSentence":"Tanadopa works by increasing the levels of norepinephrine in the brain, which can help to improve alertness and attention.","technicalDetail":"Tanadopa acts as a norepinephrine reuptake inhibitor, increasing the concentration of norepinephrine in the synaptic cleft by blocking its reabsorption into the presynaptic neuron."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/938","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DOCARPAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:48:15.687288","biosimilars":[],"competitors":[],"genericName":"docarpamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"6641","NDDF":"004721","UNII":"RPQ57D8S72","CHEBI":"CHEBI:31513","VANDF":"4019733","INN_ID":"6258","RXNORM":"3628","UMLSCUI":"C0075755","ChEMBL_ID":"CHEMBL2106351","KEGG_DRUG":"D01903","DRUGBANK_ID":"DB00988","PDB_CHEM_ID":" LDP","PUBCHEM_CID":"71137","SNOMEDCT_US":"412383006","MESH_DESCRIPTOR_UI":"D004298","MESH_SUPPLEMENTAL_RECORD_UI":"C052143"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2013","pmid":"23676366","title":"Efficacy and limitations of oral inotropic agents for the treatment of chronic heart failure.","journal":"International heart journal"},{"date":"2009 Sep","pmid":"19743995","title":"Ascites and spontaneous bacterial peritonitis: an Asian perspective.","journal":"Journal of gastroenterology and hepatology"},{"date":"2006 Mar","pmid":"16439609","title":"Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.","journal":"Clinical chemistry"},{"date":"2003 Aug","pmid":"14503971","title":"Treatment for ovarian hyperstimulation syndrome using an oral dopamine prodrug, docarpamine.","journal":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology"},{"date":"2002 May","pmid":"11996645","title":"The therapeutic potential of dopamine modulators on the cardiovascular and renal systems.","journal":"Expert opinion on investigational drugs"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tanadopa is a small molecule with the synonyms DOCARPAMINA, DOCARPAMINE, TA-870, and TANADOPA. Its modality is a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}