{"id":"dnr-npc-specific-t-cells","phase":"phase_1","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"active","trials":["NCT02065362"],"aliases":[],"patents":[],"pricing":[],"modality":"Biologic","timeline":[],"aiSummary":"","brandName":"DNR.NPC-specific T cells","companyId":"baylor-college-of-medicine","mechanism":{"target":"","novelty":"","modality":"Biologic","drugClass":"","explanation":"DNR.NPC-specific T cells are generated from a patient's own immune cells and modified to recognize antigens associated with nasopharyngeal carcinoma. These cells are expanded ex vivo and infused back into the patient to mount a targeted immune response against tumor cells.","oneSentence":"Autologous T cells engineered to recognize and attack nasopharyngeal carcinoma cells expressing tumor-associated antigens.","technicalDetail":""},"commercial":null,"_claudeStub":{"ts":1779123419,"model":"claude-sonnet-4-5-20250929"},"companyName":"Baylor College of Medicine","competitors":[{"name":"LV305","brand":null,"company":"Immune Design","rationale":"Investigational vaccine targeting NY-ESO-1 in solid tumors"},{"name":"Tumor-infiltrating lymphocytes","brand":null,"company":"Iovance Biotherapeutics","rationale":"Autologous T cell therapy for solid tumors"}],"description":"DNR.NPC-specific T cells are an investigational cellular immunotherapy developed by Baylor College of Medicine. These engineered T cells are designed to target nasopharyngeal carcinoma (NPC) by recognizing tumor-associated antigens, representing a personalized approach to treating this Epstein-Barr virus-associated malignancy.","genericName":"DNR.NPC-specific T cells","indications":{"approved":[{"status":"investigational","condition":"Nasopharyngeal carcinoma","patientPopulation":"Adult patients with recurrent or refractory disease"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"trialDetails":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"rwe":[],"genericFilers":[],"relatedDrugs":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}