{"id":"dnase","safety":{"commonSideEffects":[{"rate":null,"effect":"Voice hoarseness"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Laryngitis"},{"rate":null,"effect":"Chest pain"},{"rate":null,"effect":"Hemoptysis"},{"rate":null,"effect":"Dyspnea"}]},"_chembl":{"chemblId":"CHEMBL1201431","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DNase cleaves extracellular deoxyribonucleic acid (DNA) that accumulates in airway secretions, particularly in cystic fibrosis patients where neutrophil-derived DNA contributes to thick, sticky mucus. By degrading this DNA, the enzyme reduces sputum viscosity and elasticity, facilitating better mucociliary clearance and improving lung function. This mechanism helps reduce airway obstruction and infection risk in patients with compromised airway clearance.","oneSentence":"DNase is a recombinant deoxyribonuclease enzyme that breaks down extracellular DNA in viscous secretions, reducing mucus viscosity and improving airway clearance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:22.533Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis (to improve airway clearance and reduce respiratory infections)"},{"name":"Bronchiectasis (off-label use in some cases)"}]},"trialDetails":[{"nctId":"NCT05453695","phase":"PHASE1","title":"Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)","status":"RECRUITING","sponsor":"McMaster University","startDate":"2023-01-17","conditions":"Sepsis, Critical Illness","enrollment":36},{"nctId":"NCT07432373","phase":"","title":"Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural 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in viscous secretions, reducing mucus viscosity and improving airway clearance. Used for Cystic fibrosis (to improve airway clearance and reduce respiratory infections), Bronchiectasis (off-label use in some cases).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}