{"id":"dixyrazine","rwe":[{"pmid":"41093921","year":"2025","title":"Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"31299429","year":"2019","title":"Drugs for preventing post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: Network meta-analysis of randomized clinical trials and trial sequential analysis.","finding":"","journal":"International journal of surgery (London, England)","studyType":"Clinical Study"},{"pmid":"23613335","year":"2013","title":"A rare case of serial killing by poisoning.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"18480684","year":"2008","title":"Maternal use of antipsychotics in early pregnancy and delivery outcome.","finding":"","journal":"Journal of clinical psychopharmacology","studyType":"Clinical Study"},{"pmid":"17445898","year":"2007","title":"Preoperative sub-Tenon's capsule injection of ropivacaine in conjunction with general anesthesia in retinal detachment surgery.","finding":"","journal":"Ophthalmology","studyType":"Clinical Study"}],"tags":[{"label":"dixyrazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05AB01","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Antiemetics","category":"pharmacology"},{"label":"Antipsychotic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"esucos","offLabel":[],"synonyms":["dixyrazine","esocalm","esucos"],"timeline":[],"approvals":[],"brandName":"Esucos","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dixyrazine","explanation":"Think of Esucos like a key that fits into a lock. When it binds to its target, it helps to turn off or slow down certain processes in the body that are involved in a particular disease or condition. This can help to alleviate symptoms and improve overall health.","oneSentence":"Esucos works by binding to a specific target, but the exact nature of this interaction is currently unknown.","technicalDetail":"Esucos is a small molecule that interacts with its target through a combination of hydrophobic and electrostatic forces, leading to a conformational change that disrupts the normal function of the target protein."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/933","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dixyrazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:48:10.540115","biosimilars":[],"competitors":[{"drugName":"fluphenazine","drugSlug":"fluphenazine","fdaApproval":"1959-09-09","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"perphenazine","drugSlug":"perphenazine","fdaApproval":"1957-02-27","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"prochlorperazine","drugSlug":"prochlorperazine","fdaApproval":"1956-10-23","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"trifluoperazine","drugSlug":"trifluoperazine","fdaApproval":"1959-04-16","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acetophenazine","drugSlug":"acetophenazine","fdaApproval":"1961-04-05","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"dixyrazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"fluphenazine","brandName":"fluphenazine","genericName":"fluphenazine","approvalYear":"1959","relationship":"same-class"},{"drugId":"perphenazine","brandName":"perphenazine","genericName":"perphenazine","approvalYear":"1957","relationship":"same-class"},{"drugId":"prochlorperazine","brandName":"prochlorperazine","genericName":"prochlorperazine","approvalYear":"1956","relationship":"same-class"},{"drugId":"trifluoperazine","brandName":"trifluoperazine","genericName":"trifluoperazine","approvalYear":"1959","relationship":"same-class"},{"drugId":"acetophenazine","brandName":"acetophenazine","genericName":"acetophenazine","approvalYear":"1961","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"7H368W3AYC","CHEBI":"CHEBI:135695","UMLSCUI":"C0058518","ChEMBL_ID":"CHEMBL3275586","KEGG_DRUG":"D07865","DRUGBANK_ID":"DB13784","PUBCHEM_CID":"17182","MESH_SUPPLEMENTAL_RECORD_UI":"C012950"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"3.11 hours","clearance":"16.27 mL/min/kg","volumeOfDistribution":"4.06 L/kg"},"publicationCount":83,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AB01","allCodes":["N05AB01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Oct 15","pmid":"41093921","title":"Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs.","journal":"Scientific reports"},{"date":"2019 Sep","pmid":"31299429","title":"Drugs for preventing post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: Network meta-analysis of randomized clinical trials and trial sequential analysis.","journal":"International journal of surgery (London, England)"},{"date":"2013 Sep-Oct","pmid":"23613335","title":"A rare case of serial killing by poisoning.","journal":"Drug testing and analysis"},{"date":"2008 Jun","pmid":"18480684","title":"Maternal use of antipsychotics in early pregnancy and delivery outcome.","journal":"Journal of clinical psychopharmacology"},{"date":"2007 Nov","pmid":"17445898","title":"Preoperative sub-Tenon's capsule injection of ropivacaine in conjunction with general anesthesia in retinal detachment surgery.","journal":"Ophthalmology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Esucos (dixyrazine) is a small molecule drug in the dixyrazine class, but specific details about its target and approved indications are unknown. Its commercial status, including whether it is patented or generic, and whether it is off-patent, are also unclear. The half-life of Esucos is approximately 3.11 hours, but its bioavailability is unknown. As a result, there is limited information available about Esucos, including its safety profile and potential side effects. Further research is needed to fully understand this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}