{"id":"divalproex-div-er","safety":{"commonSideEffects":[{"rate":"25-50%","effect":"Tremor"},{"rate":"20-30%","effect":"Nausea"},{"rate":"15-25%","effect":"Somnolence"},{"rate":"5-10%","effect":"Alopecia (hair loss)"},{"rate":"10-20%","effect":"Weight gain"},{"rate":"<1%","effect":"Hepatotoxicity"},{"rate":"<1%","effect":"Pancreatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Divalproex is a compound of sodium valproate and valproic acid that works through multiple mechanisms: it increases brain levels of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter, and inhibits histone deacetylase enzymes. These actions reduce abnormal electrical activity in the brain and stabilize mood. The extended-release (ER) formulation provides sustained drug levels over 24 hours.","oneSentence":"Divalproex inhibits histone deacetylase and enhances GABA neurotransmission, reducing neuronal excitability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:49.958Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epilepsy (seizure disorders)"},{"name":"Bipolar disorder (acute mania)"},{"name":"Migraine prophylaxis"}]},"trialDetails":[{"nctId":"NCT00183469","phase":"PHASE4","title":"Maintenance Treatment of Bipolar Depression","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2004-12","conditions":"Bipolar Disorder, Depression","enrollment":86}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Depakote ER","valproic Acid"],"phase":"marketed","status":"active","brandName":"Divalproex (DIV) ER","genericName":"Divalproex (DIV) ER","companyName":"The University of Texas Health Science Center at San Antonio","companyId":"the-university-of-texas-health-science-center-at-san-antonio","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Divalproex inhibits histone deacetylase and enhances GABA neurotransmission, reducing neuronal excitability. Used for Epilepsy (seizure disorders), Bipolar disorder (acute mania), Migraine prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}