{"id":"diuretics-plus-human-albumin","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia (if potassium-sparing diuretics used)"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Infection (albumin-related)"},{"rate":null,"effect":"Electrolyte imbalances"}]},"_chembl":{"chemblId":"CHEMBL1201451","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination leverages diuretics to mobilize excess fluid (particularly useful in edematous states) while simultaneously administering human albumin to maintain intravascular oncotic pressure and prevent hypovolemia. The albumin helps retain fluid in the vascular compartment, reducing the risk of acute kidney injury and hemodynamic collapse that can occur with diuretics alone, particularly in patients with cirrhosis or severe hypoalbuminemia.","oneSentence":"Diuretics promote fluid and sodium excretion while human albumin expands plasma volume and maintains oncotic pressure to counteract fluid shifts.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:23.296Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ascites in cirrhosis with renal dysfunction"},{"name":"Hepatorenal syndrome"},{"name":"Edema management in hypoalbuminemic states"}]},"trialDetails":[{"nctId":"NCT05867602","phase":"PHASE2","title":"High Dose Albumin in Refractory Ascites","status":"RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2019-03-25","conditions":"Ascites","enrollment":100},{"nctId":"NCT04216784","phase":"PHASE4","title":"Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients","status":"TERMINATED","sponsor":"Rush University Medical Center","startDate":"2019-12-19","conditions":"Cirrhosis, Liver, Volume Overload, Fluid Overload","enrollment":21},{"nctId":"NCT06630923","phase":"PHASE3","title":"PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS","status":"RECRUITING","sponsor":"Democritus University of Thrace","startDate":"2023-01-14","conditions":"Diuretics Drug Reactions, Heart Failure; With Decompensation, Albumin; Double","enrollment":250},{"nctId":"NCT04855097","phase":"NA","title":"Evaluation of Blood Volume Analysis- Guided Management of Decompensated Heart Failure","status":"COMPLETED","sponsor":"Daxor Corporation","startDate":"2022-05-01","conditions":"Acute Decompensated Heart Failure","enrollment":32},{"nctId":"NCT04621617","phase":"PHASE3","title":"Midodrine and Albumin in Patients With Refractory Ascites","status":"UNKNOWN","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2020-11","conditions":"Refractory Ascites","enrollment":114},{"nctId":"NCT04051437","phase":"PHASE3","title":"Plasma Exchange in Acute on Chronic Liver Failure","status":"UNKNOWN","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2019-08-15","conditions":"Cirrhosis, Liver, Acute-On-Chronic Liver Failure","enrollment":130},{"nctId":"NCT01288794","phase":"PHASE4","title":"Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis","status":"COMPLETED","sponsor":"University of Bologna","startDate":"2011-03","conditions":"Liver Cirrhosis, Ascites","enrollment":431}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Furosemide and antialdosteronic drugs","Human albumin vials 50 cc 20% solution"],"phase":"marketed","status":"active","brandName":"Diuretics plus human albumin","genericName":"Diuretics plus human albumin","companyName":"University of Bologna","companyId":"university-of-bologna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diuretics promote fluid and sodium excretion while human albumin expands plasma volume and maintains oncotic pressure to counteract fluid shifts. Used for Ascites in cirrhosis with renal dysfunction, Hepatorenal syndrome, Edema management in hypoalbuminemic states.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}