{"id":"diuretic","rwe":[],"_fda":{"id":"fece8240-12e5-4ea2-9e51-594a10940f8d","set_id":"5eee7f21-a3c4-46e0-a642-a4ca635734e3","openfda":{"nui":["N0000175833","N0000175835","N0000175980","N0000008556","N0000175089","N0000185371","N0000175629","N0000184306","M0000728","M0006342","M0016962"],"unii":["XF417D3PSL","069647RPT5","5HOC10FSIC","R2M88A4HSI","V1V998DC17","FB29QPB7US","H192N84N1G","2MS130CE0A","451W47IQ8X","JWF5YAW3QW"],"route":["ORAL"],"spl_id":["fece8240-12e5-4ea2-9e51-594a10940f8d"],"brand_name":["Herbal Diuretic Liquescence 3011"],"spl_set_id":["5eee7f21-a3c4-46e0-a642-a4ca635734e3"],"package_ndc":["63083-3011-4"],"product_ndc":["63083-3011"],"generic_name":["HERBAL DIURETIC LIQUESCENCE"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Allergens [CS]","Dietary Proteins [CS]","Plant Proteins [CS]"],"pharm_class_pe":["Decreased Coagulation Factor Activity [PE]","Increased Histamine Release [PE]","Cell-mediated Immunity [PE]"],"substance_name":["ANHYDROUS CITRIC ACID","ANTIMONY CATION (3+)","BEEF KIDNEY","BOS TAURUS ARTERY","GARLIC","MIDORIAMIN","RAUWOLFIA SERPENTINA","RENIN","SODIUM CHLORIDE","VALERIAN"],"pharm_class_epc":["Calculi Dissolution Agent [EPC]","Anti-coagulant [EPC]","Non-Standardized Food Allergenic Extract [EPC]"],"pharm_class_moa":["Acidifying Activity [MoA]","Calcium Chelating Activity [MoA]"],"manufacturer_name":["Professional Complementary Health Formulas"],"is_original_packager":[true]},"purpose":["*Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"version":"2","warnings":["WARNINGS Consult a doctor if condition worsens or if symptoms persist. Keep out of the reach of children. In case of overdose, get medical help or contact a poison control center right away. If pregnant or breastfeeding, ask a healthcare professional before use. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use."],"questions":["QUESTIONS Professional Formulas PO Box 2034 Lake Oswego, OR 97035"],"effective_time":"20260108","active_ingredient":["ACTIVE INGREDIENTS Valeriana officinalis 2X Citricum acidum 3X Potassium bitartrate 3X Allium sativum 6X Natrum muriaticum 6X Rauwolfia serpentina 6X Renin 6X Collective arterial tissue 6X, 12X, 30X Kidney 6X, 12X, 30X Midbrain 6X, 12X, 30X"],"inactive_ingredient":["INACTIVE INGREDIENTS 20% ethanol, purified water."],"indications_and_usage":["INDICATIONS For the temporary relief of bloating, swelling of extremities, minor joint stiffness, weight gain, fatigue, or occasional headache.*"],"other_safety_information":["OTHER INFORMATION Tamper resistant. If seal is broken, do not use. After opening, close container tightly and store at room temperature away from heat."],"dosage_and_administration":["DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take one full dropper up to 2 times per day. Consult a physician for use in children under 12 years of age."],"spl_product_data_elements":["Herbal Diuretic Liquescence 3011 Herbal Diuretic Liquescence VALERIAN VALERIAN ANHYDROUS CITRIC ACID ANHYDROUS CITRIC ACID ANTIMONY CATION (3+) ANTIMONY CATION (3+) GARLIC GARLIC SODIUM CHLORIDE CHLORIDE ION RAUWOLFIA SERPENTINA RAUWOLFIA SERPENTINA RENIN RENIN BOS TAURUS ARTERY BOS TAURUS ARTERY BEEF KIDNEY BEEF KIDNEY MIDORIAMIN MIDORIAMIN ALCOHOL WATER"],"pregnancy_or_breast_feeding":["If pregnant or breastfeeding, ask a healthcare professional before use."],"keep_out_of_reach_of_children":["Keep out of the reach of children."],"package_label_principal_display_panel":["LABEL Est 1985 Professional Formulas Complementary Health Herbal Diuretic Liquescence Homeopathic Remedy 4 FL. OZ. (118 mL) Label image"]},"tags":[],"safety":{"boxedWarnings":[]},"trials":[],"_chembl":{"chemblId":"CHEMBL344159","moleculeType":"Small molecule","molecularWeight":"448.95"},"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Diuretic","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:20:36.799643+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Diuretic","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:20:45.232621+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T01:21:06.655011+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:20:43.600085+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Diuretic","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:20:44.608266+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:20:34.566712+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:20:34.566762+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:21:01.859772+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:20:34.566771+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Vasopressin V2 receptor antagonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:20:45.232320+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL344159/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:20:45.131025+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"5eee7f21-a3c4-46e0-a642-a4ca635734e3","title":"HERBAL DIURETIC LIQUESCENCE 3011 (HERBAL DIURETIC LIQUESCENCE) LIQUID [PROFESSIONAL COMPLEMENTARY HEALTH FORMULAS]"},"aiSummary":"Diuretic, marketed by Reprieve Cardiovascular, Inc., is positioned in the bloating relief segment. The drug's key strength lies in its mechanism of action, which effectively addresses bloating, a common and often under-treated condition. The primary risk is the key composition patent expiry in 2028, which could lead to increased competition from generics.","ecosystem":[],"mechanism":{"drugClass":"Calculi Dissolution Agent [EPC]"},"_scrapedAt":"2026-03-28T00:35:20.893Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Diuretic","title":"Diuretic","extract":"A diuretic is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics increase the excretion of water from the body, through the kidneys. There exist several classes of diuretic, and each works in a distinct way. Alternatively, an antidiuretic, such as vasopressin, is an agent or drug which reduces the excretion of water in urine."},"references":[],"_validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T01:21:06.655576+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"indications":{"approved":[{"id":"diuretic-bloating-relief","name":"Bloating relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"diuretic-swelling-relief","name":"Swelling relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"General population","pivotalTrial":null,"restrictions":[],"patientPopulation":"General population","diagnosticRequired":null,"brandNameForIndication":""},{"id":"diuretic-joint-stiffness-relief","name":"Joint stiffness 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