{"id":"ditiocarb","rwe":[{"pmid":"39927715","year":"2025","title":"[(64)Cu]Cu(DDC)(2) NPs: A Novel PET Probe for Noninvasive Visualization of NPL4 Expression in Tumors In Vivo.","finding":"","journal":"Molecular pharmaceutics","studyType":"Clinical Study"},{"pmid":"36255253","year":"2022","title":"Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite.","finding":"","journal":"Antimicrobial agents and chemotherapy","studyType":"Clinical Study"},{"pmid":"32960936","year":"2020","title":"COP9 signalosome is an essential and druggable parasite target that regulates protein degradation.","finding":"","journal":"PLoS pathogens","studyType":"Clinical Study"},{"pmid":"31465063","year":"2019","title":"A disulfur ligand stabilization approach to construct a silver(i)-cluster-based porous framework as a sensitive SERS substrate.","finding":"","journal":"Nanoscale","studyType":"Clinical Study"},{"pmid":"29211715","year":"2017","title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.","finding":"","journal":"Nature","studyType":"Clinical Study"}],"tags":[{"label":"ditiocarb","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Gasdermin-D","category":"target"},{"label":"GSDMD","category":"gene"},{"label":"CA1","category":"gene"},{"label":"CYP2E1","category":"gene"},{"label":"Active","category":"status"},{"label":"Adjuvants, Immunologic","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiviral Agents","category":"pharmacology"},{"label":"Chelating Agents","category":"pharmacology"},{"label":"Immunologic Factors","category":"pharmacology"},{"label":"Sequestering Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":162.898,"date":"","count":22,"signal":"Radiation inflammation","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=163)"}],"commonSideEffects":[{"effect":"Radiation inflammation","drugRate":"LLR 163","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"thiocarb","offLabel":[],"synonyms":["sodium diethyldithiocarbamate","ditiocarb sodium","ditiocarb","thiocarb","N,N-Diethyldithiocarbamic acid","N,N-diethyldithiocarbamate"],"timeline":[],"approvals":[],"brandName":"Thiocarb","ecosystem":[],"mechanism":{"target":"Cytochrome P450 2E1, Gasdermin-D, Histone-lysine N-methyltransferase EHMT1","targets":[{"gene":"GSDMD","source":"DrugCentral","target":"Gasdermin-D","protein":"Gasdermin-D"},{"gene":"CA1","source":"DrugCentral","target":"Carbonic anhydrase 1","protein":"Carbonic anhydrase 1"},{"gene":"CYP2E1","source":"DrugCentral","target":"Cytochrome P450 2E1","protein":"Cytochrome P450 2E1"},{"gene":"CA12","source":"DrugCentral","target":"Carbonic anhydrase 12","protein":"Carbonic anhydrase 12"},{"gene":"CA9","source":"DrugCentral","target":"Carbonic anhydrase 9","protein":"Carbonic anhydrase 9"},{"gene":"CA2","source":"DrugCentral","target":"Carbonic anhydrase 2","protein":"Carbonic anhydrase 2"},{"gene":"CA4","source":"DrugCentral","target":"Carbonic anhydrase 4","protein":"Carbonic anhydrase 4"},{"gene":"EHMT2","source":"DrugCentral","target":"Histone-lysine N-methyltransferase EHMT2","protein":"Histone-lysine N-methyltransferase EHMT2"},{"gene":"EHMT1","source":"DrugCentral","target":"Histone-lysine N-methyltransferase EHMT1","protein":"Histone-lysine N-methyltransferase EHMT1"}],"modality":"Small Molecule","drugClass":"ditiocarb","explanation":"Think of Gasdermin-D like a switch that turns on inflammation and cell death. Thiocarb is like a key that locks this switch, preventing it from being turned on and reducing inflammation and cell death. This can help to treat conditions where inflammation and cell death are a problem.","oneSentence":"Thiocarb works by inhibiting the activity of Gasdermin-D, a protein that plays a key role in the inflammatory response and cell death.","technicalDetail":"Thiocarb binds to Gasdermin-D, preventing its oligomerization and subsequent pore formation, which is essential for its pro-inflammatory and cytotoxic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/931","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DITIOCARB","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DITIOCARB","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:48:05.652692","biosimilars":[],"competitors":[{"drugName":"acetazolamide","drugSlug":"acetazolamide","fdaApproval":"1953-07-27","genericCount":29,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"ditiocarb","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetazolamide","brandName":"acetazolamide","genericName":"acetazolamide","approvalYear":"1953","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT05210374","phase":"PHASE1","title":"Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas","status":"RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2023-03-09","conditions":["Relapsed Sarcomas"],"enrollment":24,"completionDate":"2026-12-31"},{"nctId":"NCT07477457","phase":"PHASE2","title":"A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2026-03-11","conditions":["Osteosarcoma","Metastasis"],"enrollment":45,"completionDate":"2028-03-11"},{"nctId":"NCT04234022","phase":"","title":"Zn-DDC to Target Hypoxia-NFkappaB-CSCs Pathway in Multiple Myeloma","status":"RECRUITING","sponsor":"The Royal Wolverhampton Hospitals NHS Trust","startDate":"2021-10-22","conditions":["Multiple Myeloma"],"enrollment":70,"completionDate":"2027-12"},{"nctId":"NCT06793488","phase":"EARLY_PHASE1","title":"Anxiety During Abstinence in AUD","status":"RECRUITING","sponsor":"Columbia University","startDate":"2025-09-15","conditions":["Alcohol Use Disorder"],"enrollment":60,"completionDate":"2029-08-30"},{"nctId":"NCT06319872","phase":"PHASE1","title":"The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration","status":"RECRUITING","sponsor":"University of Rochester","startDate":"2025-05-19","conditions":["Alcohol Use Disorder","Retinal Dystrophies","Age-Related Macular Degeneration","Retinitis Pigmentosa","Stargardt Disease"],"enrollment":15,"completionDate":"2029-05-19"},{"nctId":"NCT03323346","phase":"PHASE2","title":"Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer","status":"RECRUITING","sponsor":"The Institute of Molecular and Translational Medicine, Czech Republic","startDate":"2017-09-29","conditions":["Breast Neoplasm Female","Metastatic Breast Cancer"],"enrollment":150,"completionDate":"2025-12-31"},{"nctId":"NCT01777919","phase":"PHASE2","title":"Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform","status":"NOT_YET_RECRUITING","sponsor":"Olympion Medical Center","startDate":"2027-01","conditions":["Glioblastoma Multiforme"],"enrollment":32,"completionDate":"2030-01"},{"nctId":"NCT02715609","phase":"PHASE1,PHASE2","title":"Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2016-06-15","conditions":["Glioblastoma Multiforme"],"enrollment":35,"completionDate":"2024-05-12"},{"nctId":"NCT06000462","phase":"PHASE4","title":"The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Oman Ministry of Health","startDate":"2024-04-22","conditions":["Obesity","Dapagliflozin Adverse Reaction","Weight Loss","Effect of Drug"],"enrollment":150,"completionDate":"2025-12-30"},{"nctId":"NCT03891667","phase":"PHASE1,PHASE2","title":"Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease","status":"COMPLETED","sponsor":"Research Foundation for Mental Hygiene, Inc.","startDate":"2019-07-31","conditions":["Fatigue","Quality of Life"],"enrollment":11,"completionDate":"2022-03-31"},{"nctId":"NCT02671890","phase":"PHASE1","title":"Disulfiram and Chemotherapy in Treating Patients With Refractory Solid Tumors or Metastatic Pancreatic Cancer","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2016-02-25","conditions":["Metastatic Pancreatic Adenocarcinoma","Refractory Malignant Solid Neoplasm","Stage IV Pancreatic Cancer AJCC v8"],"enrollment":16,"completionDate":"2024-11-11"},{"nctId":"NCT05626920","phase":"PHASE1,PHASE2","title":"Disulfiram for Treatment of Retinal Degeneration","status":"RECRUITING","sponsor":"University of Washington","startDate":"2025-01-03","conditions":["Inherited Retinal Dystrophy Primarily Involving Sensory Retina"],"enrollment":30,"completionDate":"2025-11-01"},{"nctId":"NCT03363659","phase":"PHASE2","title":"Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2018-03-28","conditions":["Glioblastoma","Glioblastoma Multiforme"],"enrollment":15,"completionDate":"2022-01-13"},{"nctId":"NCT03198559","phase":"PHASE1,PHASE2","title":"Combination Latency Reversal With High Dose Disulfiram Plus Vorinostat in HIV-infected Individuals on ART","status":"TERMINATED","sponsor":"University of Melbourne","startDate":"2017-08-08","conditions":["HIV Infections"],"enrollment":5,"completionDate":"2019-04-09"},{"nctId":"NCT02101008","phase":"PHASE2","title":"Disulfiram and Chelated Zinc for the Rx of Disseminated Mets Mel That Has Failed First Line Therapy","status":"COMPLETED","sponsor":"University of Utah","startDate":"2010-03","conditions":["Melanoma"],"enrollment":12,"completionDate":"2013-11-27"},{"nctId":"NCT03714555","phase":"PHASE2","title":"Disulfiram-Copper Gluconate in Met Pancreas Cancer w Rising CA19-9 on Abraxane-Gemzar, FOLFIRINOX or Gemcitabine","status":"TERMINATED","sponsor":"HonorHealth Research Institute","startDate":"2019-10-17","conditions":["Metastatic Pancreatic Cancer"],"enrollment":1,"completionDate":"2020-07-29"},{"nctId":"NCT04265274","phase":"PHASE2","title":"Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.","status":"WITHDRAWN","sponsor":"National Cancer Institute, Slovakia","startDate":"2020-01-01","conditions":["Metastatic Breast Cancer"],"enrollment":0,"completionDate":"2023-01-01"},{"nctId":"NCT03950830","phase":"PHASE2","title":"Disulfiram and Cisplatin in Refractory TGCTs.","status":"COMPLETED","sponsor":"National Cancer Institute, Slovakia","startDate":"2019-05-14","conditions":["Germ Cell Tumor"],"enrollment":12,"completionDate":"2022-01-31"},{"nctId":"NCT04485130","phase":"PHASE2","title":"DISulfiram for COvid-19 (DISCO) Trial","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2021-08-18","conditions":["Covid19"],"enrollment":11,"completionDate":"2022-02-28"},{"nctId":"NCT00721526","phase":"PHASE4","title":"Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2009-08","conditions":["Alcohol Dependence","Anxiety Disorder"],"enrollment":41,"completionDate":"2012-08"},{"nctId":"NCT00729300","phase":"PHASE1,PHASE2","title":"A Study of the Relationship Between Disulfiram and Cocaine Self-administration.","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2006-04","conditions":["Cocaine Addiction"],"enrollment":52,"completionDate":"2016-06"},{"nctId":"NCT04521335","phase":"PHASE1","title":"Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma","status":"TERMINATED","sponsor":"University of Utah","startDate":"2021-05-21","conditions":["Multiple Myeloma"],"enrollment":2,"completionDate":"2022-02-06"},{"nctId":"NCT05667415","phase":"NA","title":"Treatment of Advance Gastric Cancer With Disulfiram","status":"NOT_YET_RECRUITING","sponsor":"First People's Hospital of Hangzhou","startDate":"2023-06-01","conditions":["Chemotherapy；Advanced Gastric Cancer；Cisplatin；Disulfiram"],"enrollment":40,"completionDate":"2026-06-30"},{"nctId":"NCT04502589","phase":"PHASE1,PHASE2","title":"Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder","status":"COMPLETED","sponsor":"Virginia Commonwealth University","startDate":"2020-10-15","conditions":["Alcohol Disorders"],"enrollment":4,"completionDate":"2021-08-11"},{"nctId":"NCT04287790","phase":"","title":"Promoting Medications for Alcohol Use Disorder on the General Medicine Service","status":"TERMINATED","sponsor":"Yale University","startDate":"2020-01-01","conditions":["Alcohol Use Disorder"],"enrollment":67,"completionDate":"2021-02-01"},{"nctId":"NCT05162001","phase":"EARLY_PHASE1","title":"Body Weight Response With Disulfiram in Humans","status":"UNKNOWN","sponsor":"Universidad de Guanajuato","startDate":"2021-11-21","conditions":["Obesity; Drug"],"enrollment":10,"completionDate":"2022-04-30"},{"nctId":"NCT00000650","phase":"NA","title":"An Assessment of the In Vivo Biological Effects of Diethyldithiocarbamate (DTC) in HIV-Infected Patients","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":["HIV Infections"],"enrollment":12,"completionDate":"1996-09"},{"nctId":"NCT04594343","phase":"PHASE2","title":"Clinical Study to Evaluate the Effects of Disulfiram in Patients With Moderate COVID-19","status":"COMPLETED","sponsor":"ETICA","startDate":"2020-11-20","conditions":["Covid19"],"enrollment":140,"completionDate":"2021-09-25"},{"nctId":"NCT02770378","phase":"PHASE1,PHASE2","title":"A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma","status":"COMPLETED","sponsor":"University of Ulm","startDate":"2016-11","conditions":["Glioblastoma"],"enrollment":10,"completionDate":"2020-12"},{"nctId":"NCT02963051","phase":"PHASE1","title":"A Phase Ib Study of Intravenous Copper Loading With Oral Disulfiram in Metastatic, Castration Resistant Prostate Cancer","status":"TERMINATED","sponsor":"Daniel George, MD","startDate":"2017-07-11","conditions":["Prostate Cancer"],"enrollment":9,"completionDate":"2020-02-01"},{"nctId":"NCT02678975","phase":"PHASE2,PHASE3","title":"Disulfiram in Recurrent Glioblastoma","status":"COMPLETED","sponsor":"Sahlgrenska University Hospital","startDate":"2017-01","conditions":["Glioma","Glioblastoma"],"enrollment":88,"completionDate":"2021-01-15"},{"nctId":"NCT02735577","phase":"PHASE4","title":"Neural Mechanisms of Disulfiram Effects","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2016-03","conditions":["Alcohol Use Disorder"],"enrollment":7,"completionDate":"2020-10-16"},{"nctId":"NCT00913484","phase":"PHASE2","title":"Disulfiram for Cocaine Abuse in Buprenorphine Treatment","status":"COMPLETED","sponsor":"Yale University","startDate":"2000-10","conditions":["Cocaine Dependence","Opioid Dependency"],"enrollment":177,"completionDate":"2004-02"},{"nctId":"NCT03151772","phase":"EARLY_PHASE1","title":"Bioavailability of Disulfiram and Metformin in Glioblastomas","status":"TERMINATED","sponsor":"Sahlgrenska University Hospital","startDate":"2018-01-29","conditions":["Glioblastoma"],"enrollment":3,"completionDate":"2020-09-24"},{"nctId":"NCT01286259","phase":"NA","title":"Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2011-01","conditions":["HIV-1 Infection"],"enrollment":16,"completionDate":"2014-05"},{"nctId":"NCT00000278","phase":"PHASE2","title":"Disulfiram for Cocaine-Alcohol Abuse - 3","status":"COMPLETED","sponsor":"Yale University","startDate":"1994-09","conditions":["Alcohol-Related Disorders","Cocaine-Related Disorders"],"enrollment":0,"completionDate":"1999-08"},{"nctId":"NCT01944371","phase":"PHASE1,PHASE2","title":"Short-term Disulfiram Administration to Reverse Latent HIV Infection: a Dose Escalation Study","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2013-09","conditions":["HIV","Human Immunodeficiency Virus"],"enrollment":30,"completionDate":"2014-05"},{"nctId":"NCT00580827","phase":"NA","title":"Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers","status":"COMPLETED","sponsor":"Yale University","startDate":"2003-09","conditions":["Cocaine-Related Disorder","Opiate Dependence"],"enrollment":126,"completionDate":""},{"nctId":"NCT03897790","phase":"","title":"Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients","status":"WITHDRAWN","sponsor":"University Hospital, Tours","startDate":"2019-04-02","conditions":["Hypertensive Disease","Elderly","Vasopressors","General Anesthesia"],"enrollment":0,"completionDate":"2019-04-02"},{"nctId":"NCT00571116","phase":"PHASE1","title":"Disulfiram Plus Arsenic Trioxide In Patients With Metastatic Melanoma and at Least One Prior Systemic Therapy","status":"TERMINATED","sponsor":"University of California, Irvine","startDate":"2006-09","conditions":["Metastatic Melanoma"],"enrollment":9,"completionDate":"2012-08"},{"nctId":"NCT01907165","phase":"EARLY_PHASE1","title":"Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2013-10-10","conditions":["Glioblastoma"],"enrollment":21,"completionDate":"2018-02-09"},{"nctId":"NCT01118741","phase":"NA","title":"Study of Recurrent Prostate Cancer With Rising Prostate Specific Antigen (PSA)","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2010-05","conditions":["Prostate Cancer"],"enrollment":19,"completionDate":"2012-06"},{"nctId":"NCT03212599","phase":"","title":"Disulfiram as a Modulator of Amyloid Precursor Protein-processing","status":"COMPLETED","sponsor":"Johannes Gutenberg University Mainz","startDate":"2013-05","conditions":["Alcohol Addiction"],"enrollment":17,"completionDate":"2017-07"},{"nctId":"NCT00149630","phase":"PHASE2","title":"Pharmacogenetics of Disulfiram for Cocaine","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2005-01","conditions":["Cocaine Dependence","Opioid Dependence"],"enrollment":93,"completionDate":"2009-12"},{"nctId":"NCT00142844","phase":"PHASE2","title":"Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"1999-09","conditions":["Alcohol-Related Disorders","Alcoholism","Cocaine-Related Disorders"],"enrollment":208,"completionDate":"2008-01"},{"nctId":"NCT00094289","phase":"PHASE1","title":"Interactions Between Cocaine and Ethanol and Disulfiram - 1","status":"UNKNOWN","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2004-08","conditions":["Alcohol-Related Disorders","Cocaine-Related Disorders"],"enrollment":16,"completionDate":"2005-07"},{"nctId":"NCT00256230","phase":"PHASE1,PHASE2","title":"Disulfiram in Patients With Metastatic Melanoma","status":"COMPLETED","sponsor":"John P. Fruehauf","startDate":"2002-01","conditions":["Stage IV Melanoma"],"enrollment":7,"completionDate":"2007-08"},{"nctId":"NCT00386100","phase":"PHASE4","title":"A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-10","conditions":["Diabetes Mellitus, Type 2"],"enrollment":688,"completionDate":"2009-09"},{"nctId":"NCT02134002","phase":"PHASE4","title":"A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts","status":"WITHDRAWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2014-06","conditions":["Cocaine Dependence"],"enrollment":0,"completionDate":"2016-12"},{"nctId":"NCT00350870","phase":"PHASE1","title":"CBT With Disulfiram and Contingency Management","status":"COMPLETED","sponsor":"Yale University","startDate":"2005-04","conditions":["Cocaine Abuse"],"enrollment":181,"completionDate":"2010-12"},{"nctId":"NCT00742911","phase":"PHASE1","title":"Phase I Study of Disulfiram and Copper Gluconate for the Treatment of Refractory Solid Tumors Involving the Liver","status":"COMPLETED","sponsor":"University of Utah","startDate":"2008-07","conditions":["Cancer"],"enrollment":21,"completionDate":"2013-03"},{"nctId":"NCT00878306","phase":"PHASE1","title":"Disulfiram Interactions With HIV Medications: Clinical Implications","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2008-11","conditions":["HIV Infections","Drug Abuse"],"enrollment":40,"completionDate":"2013-04"},{"nctId":"NCT00395850","phase":"PHASE2","title":"Disulfiram for Cocaine Abuse","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2007-04","conditions":["Cocaine Dependence"],"enrollment":118,"completionDate":"2011-12"},{"nctId":"NCT00731133","phase":"PHASE1,PHASE2","title":"Open-Label Disulfiram for Methamphetamine Dependence","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2008-08","conditions":["Methamphetamine Dependence"],"enrollment":15,"completionDate":"2010-09"},{"nctId":"NCT00218608","phase":"PHASE2","title":"Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2001-04","conditions":["Cocaine-Related Disorders","Opioid-Related Disorders"],"enrollment":158,"completionDate":"2007-01"},{"nctId":"NCT00431262","phase":"PHASE4","title":"Antabuse in Severe Alcoholism: an Open Controlled Study","status":"UNKNOWN","sponsor":"Psykiatrisk Center Gentofte","startDate":"2007-02","conditions":["Alcoholism"],"enrollment":60,"completionDate":"2009-06"},{"nctId":"NCT00435435","phase":"PHASE4","title":"Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence","status":"COMPLETED","sponsor":"Finnish Institute for Health and Welfare","startDate":"2000-09","conditions":["Alcohol Dependence"],"enrollment":243,"completionDate":"2005-04"},{"nctId":"NCT00002065","phase":"NA","title":"Depot Disulfiram for AIDS and ARC","status":"COMPLETED","sponsor":"St. Vincent's Medical Center","startDate":"","conditions":["HIV Infections"],"enrollment":0,"completionDate":""},{"nctId":"NCT00002069","phase":"NA","title":"A Study of DTC in Patients With AIDS and AIDS Related Complex","status":"COMPLETED","sponsor":"Merieux Institute","startDate":"","conditions":["HIV Infections"],"enrollment":0,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"99Z2744345","CHEBI":"CHEBI:144353","INN_ID":"5911","UMLSCUI":"C0012194","ChEMBL_ID":"CHEMBL961","DRUGBANK_ID":"DB02520","PDB_CHEM_ID":"DCD","PUBCHEM_CID":"8987","SECONDARY_CAS_RN":"147-84-2","MESH_DESCRIPTOR_UI":"D004050"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":27,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Mar 3","pmid":"39927715","title":"[(64)Cu]Cu(DDC)(2) NPs: A Novel PET Probe for Noninvasive Visualization of NPL4 Expression in Tumors In Vivo.","journal":"Molecular pharmaceutics"},{"date":"2022 Nov 15","pmid":"36255253","title":"Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite.","journal":"Antimicrobial agents and chemotherapy"},{"date":"2020 Sep","pmid":"32960936","title":"COP9 signalosome is an essential and druggable parasite target that regulates protein degradation.","journal":"PLoS pathogens"},{"date":"2019 Sep 21","pmid":"31465063","title":"A disulfur ligand stabilization approach to construct a silver(i)-cluster-based porous framework as a sensitive SERS substrate.","journal":"Nanoscale"},{"date":"2017 Dec 14","pmid":"29211715","title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.","journal":"Nature"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thiocarb is a small molecule with the chemical name diethyldithiocarbamate. It has been studied in clinical trials for various conditions, including metastatic melanoma, glioma, glioblastoma, and stage IV melanoma, in combination with disulfiram, arsenic trioxide, and copper.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}