{"id":"disulfiram-plus-lorazepam","safety":{"commonSideEffects":[{"rate":null,"effect":"Disulfiram-alcohol reaction (flushing, nausea, chest pain, hypotension)"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Peripheral neuropathy (disulfiram)"},{"rate":null,"effect":"Hepatotoxicity (disulfiram)"},{"rate":null,"effect":"Dependence risk (lorazepam)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Disulfiram blocks the enzyme aldehyde dehydrogenase, causing acetaldehyde accumulation if alcohol is consumed, producing an unpleasant disulfiram-alcohol reaction that discourages drinking. Lorazepam potentiates GABA neurotransmission at the CNS, reducing anxiety, tremor, and other withdrawal symptoms associated with alcohol cessation. This combination addresses both the behavioral deterrent and symptomatic management aspects of alcohol use disorder treatment.","oneSentence":"Disulfiram inhibits aldehyde dehydrogenase to create an aversive reaction to alcohol, while lorazepam is a benzodiazepine that enhances GABAergic inhibition to reduce anxiety and withdrawal symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:37:01.950Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alcohol use disorder with concurrent anxiety or withdrawal symptoms"}]},"trialDetails":[{"nctId":"NCT00721526","phase":"PHASE4","title":"Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2009-08","conditions":"Alcohol Dependence, Anxiety Disorder","enrollment":41}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"disulfiram plus lorazepam","genericName":"disulfiram plus lorazepam","companyName":"University of New Mexico","companyId":"university-of-new-mexico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Disulfiram, a small molecule aldehyde dehydrogenase inhibitor, is combined with lorazepam to treat alcohol dependence and anxiety disorder. This combination is studied in clinical trials, such as NCT00721526, to evaluate its effectiveness for these conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}