{"id":"disintegrating-placebo-tamsulosin-tablet","safety":{"commonSideEffects":[{"rate":"8-18","effect":"Retrograde ejaculation"},{"rate":"2-5","effect":"Dizziness"},{"rate":"1-3","effect":"Headache"},{"rate":"1-2","effect":"Asthenia/fatigue"},{"rate":"0.5-2","effect":"Orthostatic hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tamsulosin selectively blocks alpha-1A adrenergic receptors located on smooth muscle cells in the prostate and bladder outlet. This receptor antagonism causes smooth muscle relaxation, reducing urethral resistance and improving urine flow rate. The disintegrating tablet formulation is designed for rapid dissolution and absorption to provide faster symptom relief.","oneSentence":"Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:43.893Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Benign prostatic hyperplasia with lower urinary tract symptoms"}]},"trialDetails":[{"nctId":"NCT02058368","phase":"PHASE3","title":"Study to Compare the Efficacy and Safety of Combination Treatment With Dutasteride and Tamsulosin With Tamsulosin Monotherapy, in Men With Moderate to Severe Benign Prostatic Hyperplasia","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-02-10","conditions":"Prostatic Hyperplasia","enrollment":607}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Disintegrating placebo tamsulosin tablet","genericName":"Disintegrating placebo tamsulosin tablet","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow. Used for Benign prostatic hyperplasia with lower urinary tract symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}