{"id":"discontinuation-of-thiopurines","safety":{"commonSideEffects":[{"rate":null,"effect":"Disease relapse or flare"},{"rate":null,"effect":"Loss of remission"}]},"_chembl":{"chemblId":"CHEMBL3770173","moleculeType":"Small molecule","molecularWeight":"440.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thiopurines (azathioprine, 6-mercaptopurine) are immunosuppressive agents used in inflammatory bowel disease. Their discontinuation is a clinical management strategy to evaluate whether patients can maintain remission without these agents and to mitigate cumulative risks of bone marrow suppression, hepatotoxicity, and malignancy associated with prolonged thiopurine exposure.","oneSentence":"Discontinuation of thiopurines involves stopping the use of immunosuppressive purine analogs to assess disease control and reduce long-term toxicity risks.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:20.252Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Crohn's disease maintenance therapy de-escalation"},{"name":"Ulcerative colitis maintenance therapy de-escalation"}]},"trialDetails":[{"nctId":"NCT07248644","phase":"PHASE4","title":"Discontinuation of Thiopurine Therapy in Elderly Patients With Ulcerative Colitis","status":"NOT_YET_RECRUITING","sponsor":"Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","startDate":"2026-03-01","conditions":"Ulcerative Colitis (UC)","enrollment":304}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Discontinuation of thiopurines.","genericName":"Discontinuation of thiopurines.","companyName":"Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","companyId":"grupo-espanol-de-trabajo-en-enfermedad-de-crohn-y-colitis-ulcerosa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Discontinuation of thiopurines involves stopping the use of immunosuppressive purine analogs to assess disease control and reduce long-term toxicity risks. Used for Crohn's disease maintenance therapy de-escalation, Ulcerative colitis maintenance therapy de-escalation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}