{"id":"discontinuation-of-azathioprin","safety":{"commonSideEffects":[{"rate":null,"effect":"Disease flare or relapse of underlying autoimmune condition"},{"rate":null,"effect":"Immune reconstitution inflammatory syndrome (in some contexts)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azathioprine is a purine analog that suppresses immune cell proliferation by inhibiting inosine monophosphate dehydrogenase and other enzymes in the purine synthesis pathway. Upon discontinuation, immune function gradually recovers as the drug is eliminated and lymphocyte populations rebound. This is not a therapeutic agent itself but rather the withdrawal of an existing immunosuppressive therapy.","oneSentence":"Discontinuation of azathioprine involves the cessation of an immunosuppressive drug that inhibits purine synthesis, thereby reducing the suppression of T and B lymphocyte proliferation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:28:59.940Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Study of immune reconstitution following azathioprine withdrawal in autoimmune or transplant patients"}]},"trialDetails":[{"nctId":"NCT02779114","phase":"PHASE3","title":"RETRO (REduction of Therapy in RA Patients in Ongoing Remission)","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2009-01","conditions":"Rheumatoid Arthritis","enrollment":318},{"nctId":"NCT00492895","phase":"PHASE4","title":"Photosensitivity of the Skin Under Azathioprin in Renal Transplant Recipients","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2007-06","conditions":"Skin Cancer","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Discontinuation of Azathioprin","genericName":"Discontinuation of Azathioprin","companyName":"University of Zurich","companyId":"university-of-zurich","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Discontinuation of azathioprine involves the cessation of an immunosuppressive drug that inhibits purine synthesis, thereby reducing the suppression of T and B lymphocyte proliferation. Used for Study of immune reconstitution following azathioprine withdrawal in autoimmune or transplant patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}