{"id":"diprophylline","rwe":[{"pmid":"41546592","year":"2026","title":"Analysis of risk factors for recurrence in children with asthmatic bronchopneumonia during remission and discussion on the therapeutic effect of diprophylline combined with budesonide.","finding":"","journal":"Pakistan journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"41161449","year":"2026","title":"Diprophylline drug as an efficient inducer loaded in chitosan-gelatin-umbilical cord serum hydrogel for neural differentiation of human Wharton's jelly-derived mesenchymal stem cells in vitro.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"40335325","year":"2025","title":"Solubilizing Effect of Caffeine on Precipitate of Risperidone Oral Solution and Tea Beverage.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"40207799","year":"2025","title":"Decoding Xanthine Derivatives: Advanced Analytical, Extraction, and Quantification Techniques in Pharma and Biofluids - A Comprehensive Review.","finding":"","journal":"Critical reviews in analytical chemistry","studyType":"Clinical Study"},{"pmid":"30000536","year":"2006","title":"Dyphylline.","finding":"","journal":"","studyType":"Clinical Study"}],"tags":[{"label":"diprophylline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"cAMP-specific 3',5'-cyclic phosphodiesterase 4B","category":"target"},{"label":"PDE4B","category":"gene"},{"label":"PDE3A","category":"gene"},{"label":"R03DA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Asthma","category":"indication"},{"label":"Asthma management","category":"indication"},{"label":"Asthma night-time symptoms","category":"indication"},{"label":"Asthma-chronic obstructive pulmonary disease overlap syndrome","category":"indication"},{"label":"Bronchospasm","category":"indication"},{"label":"Chronic bronchitis","category":"indication"},{"label":"Approved 1950s","category":"decade"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Phosphodiesterase Inhibitors","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Alcoholism","Anemia","Angina pectoris","Angle-closure glaucoma","Benign prostatic hyperplasia","Breastfeeding (mother)","Chronic heart failure","Chronic myocardial ischemia","Conduction disorder of the heart","Cor pulmonale","Depressive disorder","Diabetes mellitus","Disease of liver","Disorder of cardiovascular system","Disorder of coronary artery","Dyspnea","Gastritis","Glaucoma","Heart disease","Hepatic coma","Hepatic encephalopathy","Hepatic failure","Hyperammonemia","Hypertensive disorder","Hyperthyroidism"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=diprophylline","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:58:37.544174+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:58:43.182305+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diprophylline","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:58:43.522063+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Phosphodiesterase 3A inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:58:44.614009+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1752/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:58:44.267253+00:00"}},"allNames":"diphyllin","offLabel":[],"synonyms":["dyphylline","diprophylline","aristophyllin","corphyllin","diphyllin","diphylline","diprophyllin","glyphyllin","glyphylline","hidroxiteofillina","neophyllin","neutrafillina","neutraphyllin","neutraphylline","neutroxantina","protheophylline","propyphyllin","synthophylline"],"timeline":[{"date":"1951-03-07","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Diphyllin (diprophylline) is a small molecule drug that targets cAMP-specific 3',5'-cyclic phosphodiesterase 4B. 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