{"id":"diprafenone","rwe":[{"pmid":"10566049","year":"1999","title":"Diprafenone.","finding":"","journal":"Drugs in R&D","studyType":"Clinical Study"},{"pmid":"9122271","year":"1997","title":"Enantioselective determination of diprafenone in human plasma.","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"8803526","year":"1996","title":"Influence of food on the bioavailability and some pharmacokinetic parameters of diprafenone--a novel antiarrhythmic agent.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"8739818","year":"1996","title":"Effect of diprafenone on the pharmacokinetics of digoxin.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"7560253","year":"1995","title":"Single-dose interaction study of diprafenone HCl and propranolol HCl in healthy volunteers.","finding":"","journal":"Journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"diprafenone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"KCNH2","category":"gene"},{"label":"SCN5A","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butafenone","offLabel":[],"synonyms":["diprafenone hydrochloride","diprafenone","butafenone","diprafenone HCl"],"timeline":[],"approvals":[],"brandName":"Butafenone","ecosystem":[],"mechanism":{"target":"Beta-1 adrenergic receptor, Potassium voltage-gated channel subfamily H member 2, Sodium channel protein type 5 subunit alpha","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"},{"gene":"SCN5A","source":"DrugCentral","target":"Sodium channel protein type 5 subunit alpha","protein":"Sodium channel protein type 5 subunit alpha"}],"modality":"Small Molecule","drugClass":"diprafenone","explanation":"Think of it like a key fitting into a lock. Butafenone is the key that fits into the Beta-1 adrenergic receptor, which is like a lock on the heart. When the key fits into the lock, it helps to slow down the heart rate and reduce blood pressure.","oneSentence":"Butafenone works by binding to the Beta-1 adrenergic receptor, which is involved in regulating heart rate and blood pressure.","technicalDetail":"Butafenone is a selective beta-1 adrenergic receptor antagonist that competes with endogenous catecholamines (such as epinephrine and norepinephrine) for binding to the beta-1 adrenergic receptor, thereby reducing the effects of these catecholamines on the heart."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/923","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIPRAFENONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:46:51.510879","biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"arformoterol","drugSlug":"arformoterol","fdaApproval":"2006-10-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"diprafenone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"arbutamine","brandName":"arbutamine","genericName":"arbutamine","approvalYear":"1997","relationship":"same-target"},{"drugId":"arformoterol","brandName":"arformoterol","genericName":"arformoterol","approvalYear":"2006","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-target"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"1P35MD5C1F","CHEBI":"CHEBI:135559","INN_ID":"5257","UMLSCUI":"C0058420","ChEMBL_ID":"CHEMBL441809","PUBCHEM_CID":"71249","SECONDARY_CAS_RN":"86342-43-0","MESH_SUPPLEMENTAL_RECORD_UI":"C047546"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.5 hours","clearance":"11.0 mL/min/kg","fractionUnbound":"0.017%","volumeOfDistribution":"1.2 L/kg"},"publicationCount":32,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"1999 Apr","pmid":"10566049","title":"Diprafenone.","journal":"Drugs in R&D"},{"date":"1997 Feb","pmid":"9122271","title":"Enantioselective determination of diprafenone in human plasma.","journal":"Die Pharmazie"},{"date":"1996","pmid":"8803526","title":"Influence of food on the bioavailability and some pharmacokinetic parameters of diprafenone--a novel antiarrhythmic agent.","journal":"European journal of clinical pharmacology"},{"date":"1996","pmid":"8739818","title":"Effect of diprafenone on the pharmacokinetics of digoxin.","journal":"European journal of clinical pharmacology"},{"date":"1995 Jul","pmid":"7560253","title":"Single-dose interaction study of diprafenone HCl and propranolol HCl in healthy volunteers.","journal":"Journal of clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Butafenone, also known as Diprafenone, is a small molecule drug that targets the Beta-1 adrenergic receptor. It is classified as a diprafenone and its mechanism of action is not well-documented. As a result, there is limited information available on its approved indications, commercial status, and key safety considerations. Further research is needed to fully understand the properties and effects of Butafenone. Unfortunately, due to the lack of available information, a comprehensive summary cannot be provided.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}