{"id":"dipivefrine","rwe":[{"pmid":"39079933","year":"2024","title":"Cu-Electrocatalysis Enables Vicinal Bis(difluoromethylation) of Alkenes: Unraveling Dichotomous Role of Zn(CF(2)H)(2)(DMPU)(2) as Both Radical and Anion Source.","finding":"","journal":"Journal of the American Chemical Society","studyType":"Clinical Study"},{"pmid":"38719664","year":"2024","title":"Colorectal cancer subtyping and immune landscape analysis based on natural killer cell-related genes.","finding":"","journal":"Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology","studyType":"Clinical Study"},{"pmid":"32667665","year":"2020","title":"Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19).","finding":"","journal":"Pathogens and disease","studyType":"Clinical Study"},{"pmid":"20638811","year":"2010","title":"Comparison of chiral electrophoretic separation methods for phenethylamines and application on impurity analysis.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"20127386","year":"2010","title":"Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests.","finding":"","journal":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","studyType":"Clinical Study"}],"tags":[{"label":"Adrenergic Receptor Agonist","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Alpha-2A adrenergic receptor","category":"target"},{"label":"ADRA2A","category":"gene"},{"label":"ADRA2B","category":"gene"},{"label":"ADRA2C","category":"gene"},{"label":"S01EA02","category":"atc"},{"label":"Active","category":"status"},{"label":"Open-angle glaucoma","category":"indication"},{"label":"Allergan","category":"company"},{"label":"Approved 1980s","category":"decade"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Mydriatics","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/inhalational-anesthetics","drug":"Inhalational Anesthetics","action":"Use caution","effect":"Inhalational Anesthetics may enhance the arrhythmogenic effect of Alpha/Beta Agonists","source":"DrugCentral","drugSlug":"inhalational-anesthetics"}],"contraindications":["Angle-closure glaucoma","Aphakia"]},"trials":[],"aliases":[],"company":"AbbVie","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=dipivefrine","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:28:38.087357+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:28:43.607986+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dipivefrine","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:28:43.905617+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201262/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:28:44.601484+00:00"}},"allNames":"dipivefrin","offLabel":[],"synonyms":["dipivefrin hydrochloride","dipivefrin","dipivefrine","dipivefrin HCl"],"timeline":[{"date":"1980-05-02","type":"positive","source":"DrugCentral","milestone":"FDA approval (Allergan)"}],"aiSummary":"Dipivefrin, developed by Allergan, is a small molecule adrenergic receptor agonist targeting the alpha-2A adrenergic receptor. It is used to treat open-angle glaucoma, a condition characterized by increased intraocular pressure. Dipivefrin is a commercially available medication, with its original developer and current owner being Allergan. It was FDA-approved in 1980. As an adrenergic receptor agonist, dipivefrin works by stimulating the alpha-2A adrenergic receptor to decrease intraocular pressure.","approvals":[{"date":"1980-05-02","orphan":false,"company":"ALLERGAN","regulator":"FDA"}],"brandName":"Dipivefrin","ecosystem":[{"indication":"Open-angle glaucoma","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"apraclonidine","slug":"apraclonidine","company":"Alcon"},{"name":"betaxolol","slug":"betaxolol","company":"Alcon"},{"name":"bimatoprost","slug":"bimatoprost","company":""}],"globalPrevalence":null}],"mechanism":{"target":"Alpha-2A adrenergic receptor","novelty":"Follow-on","targets":[{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"}],"moaClass":"Adrenergic Agonists","modality":"Small Molecule","drugClass":"Adrenergic Receptor Agonist","explanation":"","oneSentence":"","technicalDetail":"Dipivefrin acts as an agonist at the alpha-2A adrenergic receptor, leading to vasoconstriction of the uveal vessels and a subsequent decrease in aqueous humor production, resulting in reduced intraocular pressure."},"commercial":{"launchDate":"1980","_launchSource":"DrugCentral (FDA 1980-05-02, ALLERGAN)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/922","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dipivefrine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dipivefrine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:41:50.395854","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:28:46.216306+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"epinephrine","drugSlug":"epinephrine","fdaApproval":"1948-11-19","patentExpiry":"Oct 20, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"apraclonidine","drugSlug":"apraclonidine","fdaApproval":"1987-12-31","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clonidine","drugSlug":"clonidine","fdaApproval":"1974-09-03","patentExpiry":"Sep 8, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"brimonidine","drugSlug":"brimonidine","fdaApproval":"1996-09-06","patentExpiry":"Mar 25, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"dipivefrine","indications":{"approved":[{"name":"Open-angle glaucoma","source":"DrugCentral","snomedId":84494001,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"epinephrine","brandName":"epinephrine","genericName":"epinephrine","approvalYear":"1948","relationship":"same-class"},{"drugId":"apraclonidine","brandName":"apraclonidine","genericName":"apraclonidine","approvalYear":"1987","relationship":"same-class"},{"drugId":"clonidine","brandName":"clonidine","genericName":"clonidine","approvalYear":"1974","relationship":"same-class"},{"drugId":"brimonidine","brandName":"brimonidine","genericName":"brimonidine","approvalYear":"1996","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05119270","phase":"NA","title":"Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two Handpieces","status":"WITHDRAWN","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2021-12-01","conditions":["Corneal Endothelial Cell Loss","Cataract","Astigmatism"],"enrollment":0,"completionDate":"2026-03"},{"nctId":"NCT07481227","phase":"","title":"FS-LASIK Versus TransPRK for Mixed Astigmatism","status":"COMPLETED","sponsor":"Assiut University","startDate":"2019-06-15","conditions":["Mixed Astigmatism"],"enrollment":39,"completionDate":"2025-06-15"},{"nctId":"NCT06294795","phase":"NA","title":"Toric Intraocular Lens Implantation in Pediatric Cataract","status":"COMPLETED","sponsor":"Kazakh Eye Research Institute","startDate":"2024-03-01","conditions":["Cataract Congenital","Astigmatism","IOL"],"enrollment":40,"completionDate":"2026-03-16"},{"nctId":"NCT06749496","phase":"NA","title":"Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear","status":"COMPLETED","sponsor":"Johnson & Johnson Vision Care, Inc.","startDate":"2025-01-07","conditions":["Astigmatism"],"enrollment":134,"completionDate":"2025-03-20"},{"nctId":"NCT07460791","phase":"","title":"Alcon Hydrus Stent Implantation - 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