{"id":"diphenidol-hydrochloride","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"drugInteractions":["Antidepressants","Antipsychotics","Other anticholinergics"],"commonSideEffects":[],"contraindications":["Hypersensitivity to diphenidol or other anticholinergics","Glaucoma","Obstructive uropathy","Severe ulcerative colitis","Refractory hypertension"],"specialPopulations":{"Elderly":"Use with caution; increased risk of side effects","Lactation":"Avoid use; excreted in breast milk","Pregnancy":"Category C; use only if clearly needed"}},"trials":[],"_chembl":{"chemblId":"CHEMBL1529","moleculeType":"Small molecule","molecularWeight":"345.91"},"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DIPHENIDOL HYDROCHLORIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:45:41.732584+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:45:47.750886+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIPHENIDOL HYDROCHLORIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:45:48.226118+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Muscarinic acetylcholine receptor M1 antagonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:45:49.849817+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1529/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:45:49.505041+00:00"}},"offLabel":[],"timeline":[{"date":"1960s","type":"Development","milestone":"First synthesized","regulator":"N/A"},{"date":"1970s","type":"Clinical","milestone":"Initial clinical trials","regulator":"N/A"},{"date":"1980s","type":"Commercial","milestone":"Limited market introduction","regulator":"N/A"}],"_dailymed":null,"aiSummary":"Diphenidol hydrochloride is an anticholinergic and antiemetic medication used primarily to treat nausea and vomiting. It works by blocking acetylcholine receptors in the central nervous system, which helps reduce symptoms of motion sickness and postoperative nausea. Despite its efficacy, diphenidol is not widely used due to the availability of more modern alternatives with better safety profiles. The drug has no FDA-approved label, indicating limited regulatory approval or use in the United States. Common side effects include drowsiness, dry mouth, and blurred vision, which can affect up to 10% of users. Due to its limited market presence, current revenue and commercial data are not readily available.","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 2A, Cytochrome P450 2D6, D(2) dopamine receptor","novelty":"Traditional","modality":"Small molecule","drugClass":"Anticholinergic","explanation":"","oneSentence":"","technicalDetail":"Diphenidol acts as a competitive antagonist at muscarinic M1 and M2 receptors, which are involved in the regulation of gastrointestinal motility and emesis."},"_scrapedAt":"2026-03-28T00:38:39.369Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"yoyGrowth":"Not available","launchDate":"Not available","annualCostUS":"Not available","currentRevenue":"Not available","patientPopulation":"Limited","peakSalesEstimate":"Not available"},"references":[],"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:45:51.151464+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":["Meclizine","Scopolamine","Promethazine","Ondansetron"],"indications":{"approved":[{"name":"Vertigo","diseaseId":"vertigo","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":["Nausea","Vomiting","Motion sickness","Postoperative nausea"],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"chemblId":"CHEMBL1529"},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Gastroenterology"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"approved","brandName":"DIPHENIDOL HYDROCHLORIDE","genericName":"DIPHENIDOL HYDROCHLORIDE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"1967","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:45:51.151464+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}