{"id":"diphenhydramine-phenylephrine-cocoa-placebo-dextromethorphan","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nervousness or excitability"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diphenhydramine blocks H1 histamine receptors to reduce allergic symptoms and promote sedation. Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction to relieve nasal congestion. Dextromethorphan is a non-opioid cough suppressant that acts on the cough center in the medulla. The placebo arm allows for comparison of symptomatic relief.","oneSentence":"This combination product uses diphenhydramine as a sedating antihistamine, phenylephrine as a nasal decongestant, dextromethorphan as a cough suppressant, with cocoa as a flavoring agent, and includes a placebo control arm.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:44:44.242Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cough, nasal congestion, and allergy symptoms associated with common cold or upper respiratory infection"}]},"trialDetails":[{"nctId":"NCT02062710","phase":"PHASE4","title":"Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2014-01","conditions":"Cough Reflex Sensitivity","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan","genericName":"diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan","companyName":"Montefiore Medical Center","companyId":"montefiore-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses diphenhydramine as a sedating antihistamine, phenylephrine as a nasal decongestant, dextromethorphan as a cough suppressant, with cocoa as a flavoring agent, and includes a placebo control arm. Used for Cough, nasal congestion, and allergy symptoms associated with common cold or upper respiratory infection.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}