{"id":"diphenadione","rwe":[{"pmid":"23363284","year":"2013","title":"Anticoagulant rodenticide screening in dogs: 123 cases (1996-2003).","finding":"","journal":"Journal of the American Veterinary Medical Association","studyType":"Clinical Study"},{"pmid":"22069565","year":"2010","title":"Warfarin toxicity and individual variability-clinical case.","finding":"","journal":"Toxins","studyType":"Clinical Study"},{"pmid":"18966902","year":"1997","title":"Determination of the rodenticides warfarin, diphenadione and chlorophacinone in soil samples by HPLC-DAD.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"8037888","year":"1994","title":"Clinically significant drug interactions with the oral anticoagulants.","finding":"","journal":"Drug safety","studyType":"Clinical Study"},{"pmid":"1457548","year":"1992","title":"Confirmation of indandione rodenticide toxicoses by mass spectrometry/mass spectrometry.","finding":"","journal":"Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc","studyType":"Clinical Study"}],"tags":[{"label":"diphenadione","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AA10","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diphacine","offLabel":[],"synonyms":["diphacinone","difenadion","diphacine","diphenadione sodium","diphenadione","diphenadion","diphenacin","diphacinon"],"timeline":[],"approvals":[],"brandName":"Diphacine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"diphenadione","explanation":"Think of it like a brake on your car's brakes. Diphacine helps slow down the process of blood clotting, which can be beneficial for people who are at risk of forming too many clots. This is especially important for people who have conditions like atrial fibrillation or have had a heart attack.","oneSentence":"Diphacine works by inhibiting the activity of vitamin K-dependent clotting factors in the blood.","technicalDetail":"Diphacine exerts its anticoagulant effect by competitively inhibiting the reduction of vitamin K-dependent clotting factors, specifically factors II, VII, IX, and X, which are essential for the coagulation cascade."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4450","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIPHENADIONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:45:50.150847","biosimilars":[],"competitors":[{"drugName":"dicoumarol","drugSlug":"dicoumarol","fdaApproval":"1944-07-31","relationship":"same-class"},{"drugName":"phenindione","drugSlug":"phenindione","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"warfarin","drugSlug":"warfarin","fdaApproval":"1954-06-08","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenprocoumon","drugSlug":"phenprocoumon","fdaApproval":"1957-12-30","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"diphenadione","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dicoumarol","brandName":"dicoumarol","genericName":"dicoumarol","approvalYear":"1944","relationship":"same-class"},{"drugId":"phenindione","brandName":"phenindione","genericName":"phenindione","approvalYear":"","relationship":"same-class"},{"drugId":"warfarin","brandName":"warfarin","genericName":"warfarin","approvalYear":"1954","relationship":"same-class"},{"drugId":"phenprocoumon","brandName":"phenprocoumon","genericName":"phenprocoumon","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002090","UNII":"54CA01C6JX","CHEBI":"CHEBI:81896","INN_ID":"557","UMLSCUI":"C0058366","ChEMBL_ID":"CHEMBL1413199","KEGG_DRUG":"D07136","DRUGBANK_ID":"DB13347","PUBCHEM_CID":"6719","SNOMEDCT_US":"20368008","MESH_SUPPLEMENTAL_RECORD_UI":"C100262"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AA10","allCodes":["B01AA10"]},"biosimilarFilings":[],"recentPublications":[{"date":"2013 Feb 15","pmid":"23363284","title":"Anticoagulant rodenticide screening in dogs: 123 cases (1996-2003).","journal":"Journal of the American Veterinary Medical Association"},{"date":"2010 Nov","pmid":"22069565","title":"Warfarin toxicity and individual variability-clinical case.","journal":"Toxins"},{"date":"1997 Sep","pmid":"18966902","title":"Determination of the rodenticides warfarin, diphenadione and chlorophacinone in soil samples by HPLC-DAD.","journal":"Talanta"},{"date":"1994 May","pmid":"8037888","title":"Clinically significant drug interactions with the oral anticoagulants.","journal":"Drug safety"},{"date":"1992 Oct","pmid":"1457548","title":"Confirmation of indandione rodenticide toxicoses by mass spectrometry/mass spectrometry.","journal":"Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diphacine, also known as DIPHENADIONE, is a small molecule drug in the diphenadione class. Its exact target is unknown, but it is used to treat certain conditions. Unfortunately, there is limited information available on its commercial status, approved indications, and pharmacokinetic properties. Further research is needed to fully understand this medication. As a result, it is difficult to provide a comprehensive summary of Diphacine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}