{"id":"dioxyline","rwe":[{"pmid":"1447889","year":"1992","title":"[The use of methyldioxyline for the prevention of local complications following hemorrhoidectomy].","finding":"","journal":"Khirurgiia","studyType":"Clinical Study"},{"pmid":"6276530","year":"1982","title":"Heterogeneity of biochemical actions among vasodilators.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"5143687","year":"1971","title":"[Dioxyline phosphate in the treatment of coronary insufficiency of the aged].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"},{"pmid":"5473785","year":"1970","title":"Antiarrhythmic actions of coronary vasodilator agents papaverine, dioxyline and verapamil.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"14399525","year":"1960","title":"Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"}],"tags":[{"label":"dioxyline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Methionine aminopeptidase 2","category":"target"},{"label":"METAP2","category":"gene"},{"label":"METAP1","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"paveril","offLabel":[],"synonyms":["dioxyline phosphate","dimoxyline","dioxyline","paveril"],"timeline":[],"approvals":[],"brandName":"Paveril","ecosystem":[],"mechanism":{"target":"Methionine aminopeptidase 1, Methionine aminopeptidase 2","targets":[{"gene":"METAP2","source":"DrugCentral","target":"Methionine aminopeptidase 2","protein":"Methionine aminopeptidase 2"},{"gene":"METAP1","source":"DrugCentral","target":"Methionine aminopeptidase 1","protein":"Methionine aminopeptidase 1"}],"modality":"Small Molecule","drugClass":"dioxyline","explanation":"Think of it like a roadblock: Paveril stops cancer cells from making the proteins they need to grow and divide. This can help slow down or even stop the growth of cancer tumors. By targeting this specific enzyme, Paveril aims to disrupt the cancer cells' ability to survive and thrive.","oneSentence":"Paveril works by blocking an enzyme called methionine aminopeptidase 2, which is crucial for cancer cells to grow and multiply.","technicalDetail":"Paveril (dioxyline) exerts its antitumor effects by competitively inhibiting methionine aminopeptidase 2 (MetAP2), a metalloprotease involved in the removal of the N-terminal methionine from newly synthesized proteins, thereby disrupting protein synthesis and cell proliferation in cancer cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/911","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dioxyline","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:40:53.363192","biosimilars":[],"competitors":[{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-target"},{"drugName":"thiabendazole","drugSlug":"thiabendazole","fdaApproval":"1967-04-07","patentStatus":"Unknown","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"dioxyline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-target"},{"drugId":"thiabendazole","brandName":"thiabendazole","genericName":"thiabendazole","approvalYear":"1967","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"000695","UNII":"46X4C9TILS","CHEBI":"CHEBI:135548","INN_ID":"208","UMLSCUI":"C0602100","ChEMBL_ID":"CHEMBL1170610","PUBCHEM_CID":"21877","SNOMEDCT_US":"28464005","MESH_SUPPLEMENTAL_RECORD_UI":"C004856"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"1992 Apr","pmid":"1447889","title":"[The use of methyldioxyline for the prevention of local complications following hemorrhoidectomy].","journal":"Khirurgiia"},{"date":"1982 Jan","pmid":"6276530","title":"Heterogeneity of biochemical actions among vasodilators.","journal":"Journal of pharmaceutical sciences"},{"date":"1971 Nov 30","pmid":"5143687","title":"[Dioxyline phosphate in the treatment of coronary insufficiency of the aged].","journal":"La Clinica terapeutica"},{"date":"1970 Jun","pmid":"5473785","title":"Antiarrhythmic actions of coronary vasodilator agents papaverine, dioxyline and verapamil.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1960 Jul 1","pmid":"14399525","title":"Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system.","journal":"Archives internationales de pharmacodynamie et de therapie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Paveril (dioxyline) is a small molecule drug that targets methionine aminopeptidase 2 (MetAP2), an enzyme involved in protein synthesis. It is a member of the dioxyline class and its exact commercial status is unknown. Paveril's mechanism of action involves inhibiting MetAP2, which is essential for cancer cell growth and survival. However, its clinical use and safety profile are not well established. Further research is needed to determine its potential as a therapeutic agent.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}